Síntese e avaliação biológica dos compostos 3-triazoilcalcogeniltimidina

Detalhes bibliográficos
Ano de defesa: 2018
Autor(a) principal: Sarturi, Joelma Menegazzi lattes
Orientador(a): Rodrigues, Oscar Endrigo Dorneles lattes
Banca de defesa: Schumacher, Ricardo Frederico lattes, Ilha, Vinicius lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Santa Maria
Centro de Ciências Naturais e Exatas
Programa de Pós-Graduação: Programa de Pós-Graduação em Química
Departamento: Química
País: Brasil
Palavras-chave em Português:
Ziduvudina
3-Triazoilcalcogeniltimidinas
Calcogenoacetilenos
Antioxidante
Antitumoral
Palavras-chave em Inglês:
Ziduvudine
3-Triazoylcalcogenylthymidines
Chalcogenoacetylenes
Antioxidant
Antitumoral
Área do conhecimento CNPq:
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
Link de acesso: http://repositorio.ufsm.br/handle/1/14774
Resumo: This work describes the synthesis and antioxidant and antitumoral activity of 3-triazoylcalcogenylthymidine (7a-o). A variety of nucleoside analogues were prepared using a Huisgen 1,3-dipolar cycloaddition, between the azide group from ziduvudine 6 and the chalcogenoacetylenes (5a-n). The compounds (7a-o) were prepared via a partial convergent synthesis, involving a previously obtention of the respective chalcogenoacetylenes (5a-n) containing electron donating and withdrawing groups attached in the aryl ring from chalcogenium portion. The evaluation of some reaction parameters as catalyst, solvent and time was performed affording in the optimal reaction condition the respective nucleosides with yields ranging from 59 to 94%.
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spelling 2018-11-07T18:59:58Z2018-11-07T18:59:58Z2018-02-26http://repositorio.ufsm.br/handle/1/14774This work describes the synthesis and antioxidant and antitumoral activity of 3-triazoylcalcogenylthymidine (7a-o). A variety of nucleoside analogues were prepared using a Huisgen 1,3-dipolar cycloaddition, between the azide group from ziduvudine 6 and the chalcogenoacetylenes (5a-n). The compounds (7a-o) were prepared via a partial convergent synthesis, involving a previously obtention of the respective chalcogenoacetylenes (5a-n) containing electron donating and withdrawing groups attached in the aryl ring from chalcogenium portion. The evaluation of some reaction parameters as catalyst, solvent and time was performed affording in the optimal reaction condition the respective nucleosides with yields ranging from 59 to 94%.O presente trabalho tem por objetivo desenvolver a síntese, atividade antioxidante e antitumoral de compostos análogos de nucleosídeos 3-triazoilcalcogeniltimidinas (7a-o). Os compostos foram obtidos através da reação de cicloadição 1,3-dipolar de Huisgen entre grupamento azida da ziduvudina 6 e os calcogenoacetilenos (5a-n) previamente sintetizados durante o trabalho. Os compostos foram preparados através de uma rota sintética parcialmente convergente, onde em uma das etapas foi realizada a síntese dos calcogenoacetilenos (5a-n) com diferentes grupamentos doadores e retiradores de elétrons adicionados ao grupamento arila ligado ao átomo de calcogênio. O estudo das diferentes condições reacionais como solvente e catalisador foram realizados, sendo que nas condições otimizadas os compostos foram obtidos com rendimentos variando de 59 à 94 %.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESporUniversidade Federal de Santa MariaCentro de Ciências Naturais e ExatasPrograma de Pós-Graduação em QuímicaUFSMBrasilQuímicaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessZiduvudina3-TriazoilcalcogeniltimidinasCalcogenoacetilenosAntioxidanteAntitumoralZiduvudine3-TriazoylcalcogenylthymidinesChalcogenoacetylenesAntioxidantAntitumoralCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICASíntese e avaliação biológica dos compostos 3-triazoilcalcogeniltimidinaSynthesis and biological evaluation of compounds 3-triazoilcalcogenylthymidinesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisRodrigues, Oscar Endrigo Dorneleshttp://lattes.cnpq.br/6536519955416085Schumacher, Ricardo Fredericohttp://lattes.cnpq.br/7856034546434135Ilha, Viniciushttp://lattes.cnpq.br/3882671719676564http://lattes.cnpq.br/6713133698480485Sarturi, Joelma Menegazzi10060000000060009fef019-ac43-4d8b-83d3-3565e4686d7ba7a413b3-8902-4373-a64e-eaf6264f6c33440aac92-1478-4cbd-9a8c-a1fa4360f55c7478688e-3aa2-4a32-9f0a-d2b661267e83reponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGQUIMICA_2018_SARTURI_JOELMA.pdfDIS_PPGQUIMICA_2018_SARTURI_JOELMA.pdfDissertação de Mestradoapplication/pdf6824658http://repositorio.ufsm.br/bitstream/1/14774/1/DIS_PPGQUIMICA_2018_SARTURI_JOELMA.pdfd947e1949aff16ea6617de06d3058ab6MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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dc.title.por.fl_str_mv Síntese e avaliação biológica dos compostos 3-triazoilcalcogeniltimidina
dc.title.alternative.eng.fl_str_mv Synthesis and biological evaluation of compounds 3-triazoilcalcogenylthymidines
title Síntese e avaliação biológica dos compostos 3-triazoilcalcogeniltimidina
spellingShingle Síntese e avaliação biológica dos compostos 3-triazoilcalcogeniltimidina
Sarturi, Joelma Menegazzi
Ziduvudina
3-Triazoilcalcogeniltimidinas
Calcogenoacetilenos
Antioxidante
Antitumoral
Ziduvudine
3-Triazoylcalcogenylthymidines
Chalcogenoacetylenes
Antioxidant
Antitumoral
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
title_short Síntese e avaliação biológica dos compostos 3-triazoilcalcogeniltimidina
title_full Síntese e avaliação biológica dos compostos 3-triazoilcalcogeniltimidina
title_fullStr Síntese e avaliação biológica dos compostos 3-triazoilcalcogeniltimidina
title_full_unstemmed Síntese e avaliação biológica dos compostos 3-triazoilcalcogeniltimidina
title_sort Síntese e avaliação biológica dos compostos 3-triazoilcalcogeniltimidina
author Sarturi, Joelma Menegazzi
author_facet Sarturi, Joelma Menegazzi
author_role author
dc.contributor.advisor1.fl_str_mv Rodrigues, Oscar Endrigo Dorneles
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/6536519955416085
dc.contributor.referee1.fl_str_mv Schumacher, Ricardo Frederico
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/7856034546434135
dc.contributor.referee2.fl_str_mv Ilha, Vinicius
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/3882671719676564
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/6713133698480485
dc.contributor.author.fl_str_mv Sarturi, Joelma Menegazzi
contributor_str_mv Rodrigues, Oscar Endrigo Dorneles
Schumacher, Ricardo Frederico
Ilha, Vinicius
dc.subject.por.fl_str_mv Ziduvudina
3-Triazoilcalcogeniltimidinas
Calcogenoacetilenos
Antioxidante
Antitumoral
topic Ziduvudina
3-Triazoilcalcogeniltimidinas
Calcogenoacetilenos
Antioxidante
Antitumoral
Ziduvudine
3-Triazoylcalcogenylthymidines
Chalcogenoacetylenes
Antioxidant
Antitumoral
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
dc.subject.eng.fl_str_mv Ziduvudine
3-Triazoylcalcogenylthymidines
Chalcogenoacetylenes
Antioxidant
Antitumoral
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
description This work describes the synthesis and antioxidant and antitumoral activity of 3-triazoylcalcogenylthymidine (7a-o). A variety of nucleoside analogues were prepared using a Huisgen 1,3-dipolar cycloaddition, between the azide group from ziduvudine 6 and the chalcogenoacetylenes (5a-n). The compounds (7a-o) were prepared via a partial convergent synthesis, involving a previously obtention of the respective chalcogenoacetylenes (5a-n) containing electron donating and withdrawing groups attached in the aryl ring from chalcogenium portion. The evaluation of some reaction parameters as catalyst, solvent and time was performed affording in the optimal reaction condition the respective nucleosides with yields ranging from 59 to 94%.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-11-07T18:59:58Z
dc.date.available.fl_str_mv 2018-11-07T18:59:58Z
dc.date.issued.fl_str_mv 2018-02-26
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufsm.br/handle/1/14774
url http://repositorio.ufsm.br/handle/1/14774
dc.language.iso.fl_str_mv por
language por
dc.relation.cnpq.fl_str_mv 100600000000
dc.relation.confidence.fl_str_mv 600
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dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
Centro de Ciências Naturais e Exatas
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Química
dc.publisher.initials.fl_str_mv UFSM
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Química
publisher.none.fl_str_mv Universidade Federal de Santa Maria
Centro de Ciências Naturais e Exatas
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações do UFSM
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reponame_str Biblioteca Digital de Teses e Dissertações do UFSM
collection Biblioteca Digital de Teses e Dissertações do UFSM
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