Síntese, análise cristalográfica e atividade biológica de complexos com ligantes triazenidos com fragmentos orto-halofenila e para-sulfonamidafenila
Ano de defesa: | 2013 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Química
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/10543 |
Resumo: | This study shows the triazenes ligands and complexes Pd(II), K+ and Au(I) obtained from reactions of the ligands with fragments para-sulfonamidephenyl, comprising triazene ligand 1,3-bis (4 - sulfonamidephenyl) (1) and the complex {trans-Bis[1,3-bis(4-sulfonamidephenyl)triazenide-κN1]bis(pyridine-κN)palladium(II)}{tetra(pyridine-κN)palladium(II)}bis(potssium)·water (2) and for compounds containing orto-halophenyl fragments represented by [1,3-bis(2-fluorophenyl)triazenide-κN1](triphenylphosphine- κP)gold(I) (3), [1,3-bis(2-chlorinephenyl)triazenide-κN1](triphenylphosphine-κP)gold(I) (4), [1,3-bis(2-bromidephenyl)triazenide-κN1](triphenylphosphine-κP)gold(I) (5) and [1,3-bis(2-iodinephenyl)triazenide-κN1](triphenylphosphine - κP)gold(I) (6) complexes. The compounds reported were characterized by X-ray diffraction on single crystal, and their structures in solid state are formed through supramolecular arrangements via classical and non-classical hydrogen bonding, as in the case of the compounds with the sulfonamide grouping, one can observe the formation of supramolecular synthons. In complexes 4, 5 and 6 it is observed to occur interactions halogen···halogen characterized by the formation of dimeric units associated by a center of inversion, besides having geometries classified by the angle of the links formed between the halogen and carbon atoms. Compounds 1, 2, 3, 4, 5 and 6 were subjected to evaluation front of biological activity, such as plasmidial DNA cleavage studies, evaluation of cytotoxicity and antibacterial activity, showing promising results. |
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2017-05-222017-05-222013-03-08ZAMBIAZI, Priscilla Jussiane. Synthesis, crystallographic analysis and biological activity of the complexes with triazenides ligands with orto-halophenyl and para-sulfonamidephenyl fragments. 2013. 168 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2013.http://repositorio.ufsm.br/handle/1/10543This study shows the triazenes ligands and complexes Pd(II), K+ and Au(I) obtained from reactions of the ligands with fragments para-sulfonamidephenyl, comprising triazene ligand 1,3-bis (4 - sulfonamidephenyl) (1) and the complex {trans-Bis[1,3-bis(4-sulfonamidephenyl)triazenide-κN1]bis(pyridine-κN)palladium(II)}{tetra(pyridine-κN)palladium(II)}bis(potssium)·water (2) and for compounds containing orto-halophenyl fragments represented by [1,3-bis(2-fluorophenyl)triazenide-κN1](triphenylphosphine- κP)gold(I) (3), [1,3-bis(2-chlorinephenyl)triazenide-κN1](triphenylphosphine-κP)gold(I) (4), [1,3-bis(2-bromidephenyl)triazenide-κN1](triphenylphosphine-κP)gold(I) (5) and [1,3-bis(2-iodinephenyl)triazenide-κN1](triphenylphosphine - κP)gold(I) (6) complexes. The compounds reported were characterized by X-ray diffraction on single crystal, and their structures in solid state are formed through supramolecular arrangements via classical and non-classical hydrogen bonding, as in the case of the compounds with the sulfonamide grouping, one can observe the formation of supramolecular synthons. In complexes 4, 5 and 6 it is observed to occur interactions halogen···halogen characterized by the formation of dimeric units associated by a center of inversion, besides having geometries classified by the angle of the links formed between the halogen and carbon atoms. Compounds 1, 2, 3, 4, 5 and 6 were subjected to evaluation front of biological activity, such as plasmidial DNA cleavage studies, evaluation of cytotoxicity and antibacterial activity, showing promising results.Este trabalho apresenta o estudo de ligantes triazenos e complexos de Pd(II), K+ e Au(I) obtidos a partir de reações com os ligantes com fragmentos para-sulfonamidafenila compreendendo o ligante 1,3-bis-(4-sulfonamidafenil)triazeno (1) e o complexo {trans-Bis[1,3-bis(4-sulfonamidafenil)triazenido-κN1]bis(piridina-κN)paládio(II)}{tetra(piridina-κN)paládio(II)}bis(potássio)·água (2) e para compostos contendo fragmentos orto-halofenila representados pelos complexos [1,3-bis(2-fluorofenil)triazenido-κN1](trifenilfosfina- κP)ouro(I) (3), [1,3-bis(2-clorofenil)triazenido-κN1](trifenilfosfina- κP)ouro(I) (4), [1,3-bis(2-bromofenil)triazenido-κN1](trifenilfosfina- κP)ouro(I) (5) e [1,3-bis(2-iodofenil)triazenido-κ-N1](trifenilfosfina- κP)ouro(I) (6). Os compostos relatados foram caracterizados por difração de raios X em monocristal, e suas estruturas no estado sólido são formadas através de arranjos supramoleculares via ligações de hidrogênio clássicas e não clássicas, como no caso dos compostos com o grupamento sulfonamida, pode-se observar a formação de synthons supramoleculares. Nos complexos 4, 5 e 6 é observada a ocorrência de interações halogênio···halogênio caracterizadas pela formação de unidades díméricas associadas por um centro de inversão, além de apresentarem geometrias classificadas pelo ângulo de ligações formado entre os átomos de halogênio e carbono. Os compostos 1, 2, 3, 4, 5 e 6 foram submetidos a avaliação frente a atividade biológica, como estudos na clivagem do DNA plasmidial, avaliação da citotoxicidade e atividade antibacteriana, mostrando resultados promissores.Conselho Nacional de Desenvolvimento Científico e Tecnológicoapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em QuímicaUFSMBRQuímicaTriazenosComplexos de Pd(II)K+ e Au(I)Synthons supramolecularesInterações halogênio···halogênioAtividade biológicaTriazenesComplexes of Pd(II)K+ and Au(I)Supramolecular synthonsHalogen···halogen interactionsBiological activityCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICASíntese, análise cristalográfica e atividade biológica de complexos com ligantes triazenidos com fragmentos orto-halofenila e para-sulfonamidafenilaSynthesis, crystallographic analysis and biological activity of the complexes with triazenides ligands with orto-halophenyl and para-sulfonamidephenyl fragmentsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisHörner, Manfredohttp://lattes.cnpq.br/8922528250830998Bresolin, Leandrohttp://lattes.cnpq.br/3961672079507969Squizani, Fatimahttp://lattes.cnpq.br/1060502818943139http://lattes.cnpq.br/5833091143764435Zambiazi, Priscilla Jussiane1006000000004005003003005007e7796b1-053d-4bbe-8e62-e769f0da5cea362da7d8-5946-4f2b-8ecd-f9f5df3600af455eae8e-d46f-4e15-8c0d-249c48314f836c576d48-34e1-4008-b46b-a68350c55a17info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALZAMBIAZI, PRISCILA JUSSIANE.pdfapplication/pdf10163252http://repositorio.ufsm.br/bitstream/1/10543/1/ZAMBIAZI%2c%20PRISCILA%20JUSSIANE.pdf0fe47a1bd4ebf627a10d16cfcd6804b6MD51TEXTZAMBIAZI, PRISCILA JUSSIANE.pdf.txtZAMBIAZI, PRISCILA JUSSIANE.pdf.txtExtracted texttext/plain212051http://repositorio.ufsm.br/bitstream/1/10543/2/ZAMBIAZI%2c%20PRISCILA%20JUSSIANE.pdf.txt27706e2a3ddce58c6189004886aee50aMD52THUMBNAILZAMBIAZI, PRISCILA JUSSIANE.pdf.jpgZAMBIAZI, PRISCILA JUSSIANE.pdf.jpgIM Thumbnailimage/jpeg5765http://repositorio.ufsm.br/bitstream/1/10543/3/ZAMBIAZI%2c%20PRISCILA%20JUSSIANE.pdf.jpgb8de3a9c3303e4e48bea2c2e1c651801MD531/105432022-05-11 10:37:26.437oai:repositorio.ufsm.br:1/10543Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-05-11T13:37:26Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Síntese, análise cristalográfica e atividade biológica de complexos com ligantes triazenidos com fragmentos orto-halofenila e para-sulfonamidafenila |
dc.title.alternative.eng.fl_str_mv |
Synthesis, crystallographic analysis and biological activity of the complexes with triazenides ligands with orto-halophenyl and para-sulfonamidephenyl fragments |
title |
Síntese, análise cristalográfica e atividade biológica de complexos com ligantes triazenidos com fragmentos orto-halofenila e para-sulfonamidafenila |
spellingShingle |
Síntese, análise cristalográfica e atividade biológica de complexos com ligantes triazenidos com fragmentos orto-halofenila e para-sulfonamidafenila Zambiazi, Priscilla Jussiane Triazenos Complexos de Pd(II) K+ e Au(I) Synthons supramoleculares Interações halogênio···halogênio Atividade biológica Triazenes Complexes of Pd(II) K+ and Au(I) Supramolecular synthons Halogen···halogen interactions Biological activity CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Síntese, análise cristalográfica e atividade biológica de complexos com ligantes triazenidos com fragmentos orto-halofenila e para-sulfonamidafenila |
title_full |
Síntese, análise cristalográfica e atividade biológica de complexos com ligantes triazenidos com fragmentos orto-halofenila e para-sulfonamidafenila |
title_fullStr |
Síntese, análise cristalográfica e atividade biológica de complexos com ligantes triazenidos com fragmentos orto-halofenila e para-sulfonamidafenila |
title_full_unstemmed |
Síntese, análise cristalográfica e atividade biológica de complexos com ligantes triazenidos com fragmentos orto-halofenila e para-sulfonamidafenila |
title_sort |
Síntese, análise cristalográfica e atividade biológica de complexos com ligantes triazenidos com fragmentos orto-halofenila e para-sulfonamidafenila |
author |
Zambiazi, Priscilla Jussiane |
author_facet |
Zambiazi, Priscilla Jussiane |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Hörner, Manfredo |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/8922528250830998 |
dc.contributor.referee1.fl_str_mv |
Bresolin, Leandro |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/3961672079507969 |
dc.contributor.referee2.fl_str_mv |
Squizani, Fatima |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/1060502818943139 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5833091143764435 |
dc.contributor.author.fl_str_mv |
Zambiazi, Priscilla Jussiane |
contributor_str_mv |
Hörner, Manfredo Bresolin, Leandro Squizani, Fatima |
dc.subject.por.fl_str_mv |
Triazenos Complexos de Pd(II) K+ e Au(I) Synthons supramoleculares Interações halogênio···halogênio Atividade biológica |
topic |
Triazenos Complexos de Pd(II) K+ e Au(I) Synthons supramoleculares Interações halogênio···halogênio Atividade biológica Triazenes Complexes of Pd(II) K+ and Au(I) Supramolecular synthons Halogen···halogen interactions Biological activity CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Triazenes Complexes of Pd(II) K+ and Au(I) Supramolecular synthons Halogen···halogen interactions Biological activity |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
This study shows the triazenes ligands and complexes Pd(II), K+ and Au(I) obtained from reactions of the ligands with fragments para-sulfonamidephenyl, comprising triazene ligand 1,3-bis (4 - sulfonamidephenyl) (1) and the complex {trans-Bis[1,3-bis(4-sulfonamidephenyl)triazenide-κN1]bis(pyridine-κN)palladium(II)}{tetra(pyridine-κN)palladium(II)}bis(potssium)·water (2) and for compounds containing orto-halophenyl fragments represented by [1,3-bis(2-fluorophenyl)triazenide-κN1](triphenylphosphine- κP)gold(I) (3), [1,3-bis(2-chlorinephenyl)triazenide-κN1](triphenylphosphine-κP)gold(I) (4), [1,3-bis(2-bromidephenyl)triazenide-κN1](triphenylphosphine-κP)gold(I) (5) and [1,3-bis(2-iodinephenyl)triazenide-κN1](triphenylphosphine - κP)gold(I) (6) complexes. The compounds reported were characterized by X-ray diffraction on single crystal, and their structures in solid state are formed through supramolecular arrangements via classical and non-classical hydrogen bonding, as in the case of the compounds with the sulfonamide grouping, one can observe the formation of supramolecular synthons. In complexes 4, 5 and 6 it is observed to occur interactions halogen···halogen characterized by the formation of dimeric units associated by a center of inversion, besides having geometries classified by the angle of the links formed between the halogen and carbon atoms. Compounds 1, 2, 3, 4, 5 and 6 were subjected to evaluation front of biological activity, such as plasmidial DNA cleavage studies, evaluation of cytotoxicity and antibacterial activity, showing promising results. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-03-08 |
dc.date.accessioned.fl_str_mv |
2017-05-22 |
dc.date.available.fl_str_mv |
2017-05-22 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ZAMBIAZI, Priscilla Jussiane. Synthesis, crystallographic analysis and biological activity of the complexes with triazenides ligands with orto-halophenyl and para-sulfonamidephenyl fragments. 2013. 168 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/10543 |
identifier_str_mv |
ZAMBIAZI, Priscilla Jussiane. Synthesis, crystallographic analysis and biological activity of the complexes with triazenides ligands with orto-halophenyl and para-sulfonamidephenyl fragments. 2013. 168 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2013. |
url |
http://repositorio.ufsm.br/handle/1/10543 |
dc.language.iso.fl_str_mv |
por |
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por |
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100600000000 |
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400 500 300 300 500 |
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Universidade Federal de Santa Maria |
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Programa de Pós-Graduação em Química |
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UFSM |
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BR |
dc.publisher.department.fl_str_mv |
Química |
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Universidade Federal de Santa Maria |
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