Migração de metais por interação das embalagens com soluções parenterais
Ano de defesa: | 2008 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Química
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/4166 |
Resumo: | The administration of medication and nutrients via parenteral is very used nowadays. One of the risks of this procedure is the presence of contaminants, which depending on their nature may cause severe damage to the patients due to the direct way of the administration (in the circulatory stream). In this work we investigated the possibility of the containers to be sources of metals for solutions of parenteral nutrition. The investigated containers are made of different kinds of glass and plastic polymers, namely polypropylene, PVC and EVA. The system container/solution (amino acids, salts, glucose and lipids) individually stored, was submitted to the sterilization process and after that stored for a time period of approximately 10 months, since the shelf-life period of these formulations are generally 2 years. After the sterilization and at regular time intervals, aliquots of each solution were collected and their contents on Al, Pb, Cd, Fe, Cr, Mn, Ba, and Zn were measured by graphite furnace atomic absorption spectrometry. The containers were also analyzed for the determination of the amount of each metal they contained. These metals are either constituents of the container material, as Al in glasses, or impurities in the case of plastic polymers. All containers presented the metals investigated. The solutions, depending on their composition (species dissolved) were able to extract the metals either from the glass or the polymers. The highest extraction rates occurred in solutions of the amino acids cysteine and glutamic acid, and in solutions of NaHCO3. The metals released in higher concentration were Ba, Pb and Zn form plastic containers and Al, Pb and Zn form glass containers. A different behavior was observed among the plastic polymers, and the different kinds of glass. While EVA was the most inert polymer, the clear glass ampoule released the highest amount of metals into the solutions. Fifty commercial samples were analyzed as well, and the investigated metals were found in all of them. The commercial formulations presented the same tendency of the individual sample used in the study, either in relation to the behavior of the substance in solution or the container material. |
id |
UFSM_871e1639a857e2ea461a451c5752a86a |
---|---|
oai_identifier_str |
oai:repositorio.ufsm.br:1/4166 |
network_acronym_str |
UFSM |
network_name_str |
Biblioteca Digital de Teses e Dissertações do UFSM |
repository_id_str |
|
spelling |
2017-05-152017-05-152008-06-19BERTAGNOLLI, Denise de Castro. Migration of metals by the interaction of packages with pararenteral solutions. 2008. 258 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2008.http://repositorio.ufsm.br/handle/1/4166The administration of medication and nutrients via parenteral is very used nowadays. One of the risks of this procedure is the presence of contaminants, which depending on their nature may cause severe damage to the patients due to the direct way of the administration (in the circulatory stream). In this work we investigated the possibility of the containers to be sources of metals for solutions of parenteral nutrition. The investigated containers are made of different kinds of glass and plastic polymers, namely polypropylene, PVC and EVA. The system container/solution (amino acids, salts, glucose and lipids) individually stored, was submitted to the sterilization process and after that stored for a time period of approximately 10 months, since the shelf-life period of these formulations are generally 2 years. After the sterilization and at regular time intervals, aliquots of each solution were collected and their contents on Al, Pb, Cd, Fe, Cr, Mn, Ba, and Zn were measured by graphite furnace atomic absorption spectrometry. The containers were also analyzed for the determination of the amount of each metal they contained. These metals are either constituents of the container material, as Al in glasses, or impurities in the case of plastic polymers. All containers presented the metals investigated. The solutions, depending on their composition (species dissolved) were able to extract the metals either from the glass or the polymers. The highest extraction rates occurred in solutions of the amino acids cysteine and glutamic acid, and in solutions of NaHCO3. The metals released in higher concentration were Ba, Pb and Zn form plastic containers and Al, Pb and Zn form glass containers. A different behavior was observed among the plastic polymers, and the different kinds of glass. While EVA was the most inert polymer, the clear glass ampoule released the highest amount of metals into the solutions. Fifty commercial samples were analyzed as well, and the investigated metals were found in all of them. The commercial formulations presented the same tendency of the individual sample used in the study, either in relation to the behavior of the substance in solution or the container material.Atualmente a administração parenteral, tanto de medicamentos quanto nutrientes, é uma prática muito difundida. Um dos riscos desta prática é a presença de contaminantes que, dependendo da sua natureza, podem acarretar graves danos aos pacientes devido à forma direta (na corrente circulatória) da administração. Neste trabalho, investigou-se a possibilidade das embalagens serem fontes de contaminação por metais de soluções utilizadas na nutrição parenteral. As embalagens investigadas incluíram vários tipos de vidro e polímeros plásticos mais comumente utilizados (polipropileno, polivinil cloreto (PVC) e etil vinil acetato(EVA)). As embalagens, nas quais foram armazenados individualmente os constituintes das soluções parenterais (aminoácidos, sais, glicose, vitaminas e lipídeos), foram submetidas ao processo de esterilização e de armazenagem a longo prazo, visto que a validade deste tipo de formulação é geralmente de 2 anos. Após a esterilização e em intervalos de tempo regulares, alíquotas das soluções foram retiradas e os teores em Al, Pb, Cd, Fe, Cr, Mn, Ba e Zn foram medidos por espectrometria de absorção atômica forno de grafite (GF AAS) e espectrometria de massa com plasma indutivamente acoplado (ICP-MS). As embalagens utilizadas foram também analisadas para determinar quanto dos metais em estudo elas apresentavam, seja como constituinte, como é o caso do Al no vidro, ou como impureza, no caso de todos os metais nos polímeros plásticos. Todas as embalagens continham os metais em estudo em maior ou menor concentração. As soluções, dependendo dos seus constituintes foram capazes de extrair os metais, tanto do vidro quanto do plástico. As maiores taxas de extração ocorreram com as soluções dos aminoácidos cisteína e acido glutâmico. Os metais extraídos em maiores quantidades foram Ba, Pb e Zn das embalagens plásticas e Al, Pb e Zn das embalagens de vidro. Observou-se diferente comportamento entre os diferentes polímeros e tipos de vidro. O EVA mostrou-se o polímero mais inerte, enquanto que as ampolas transparentes foram as que mais metais liberaram para as soluções. Foram analisadas, também, 50 amostras comerciais, as quais se mostraram contaminadas pelos metais em estudo. Observou-se nas soluções comerciais a mesma tendência das soluções individuais do estudo, tanto com relação ao comportamento da embalagem, quanto ao conteúdo (ação do componente sobre a embalagem) e os metais extraídos.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em QuímicaUFSMBRQuímicaNutrição parenteralEmbalagens plásticasEmbalagens de vidroParenteral nutritionPlastic containersGlass containersCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICAMigração de metais por interação das embalagens com soluções parenteraisMigration of metals by the interaction of packages with pararenteral solutionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisNascimento, Denise Bohrer dohttp://lattes.cnpq.br/9817093263802769Cardoso, Simone Gonçalveshttp://lattes.cnpq.br/0137281979458686Limberger, Renata Pereirahttp://lattes.cnpq.br/7116144690986974Emanuelli, Tatianahttp://lattes.cnpq.br/2165391096880394Carvalho, Leandro Machado dehttp://lattes.cnpq.br/6652387343920028http://lattes.cnpq.br/6727744713310620Bertagnolli, Denise de Castro1006000000004005003003003005003001c5af0ad-15cf-4a7e-9b25-b8b6b1363ae670776a36-aae3-4f93-bfba-9ea048388fb1d74914cc-c0c9-4458-b1af-49d276dd86ae0502dec6-ae3d-4c37-850e-2b7c6c6cba647457e618-e257-4f1d-b319-f58982632184369e0f2d-1b60-4076-ac06-58a85a76f15binfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDENISEDECASTROBERTAGNOLLI.pdfapplication/pdf1413747http://repositorio.ufsm.br/bitstream/1/4166/1/DENISEDECASTROBERTAGNOLLI.pdfa74f50f358379fe70b78a07bcdbe121dMD51TEXTDENISEDECASTROBERTAGNOLLI.pdf.txtDENISEDECASTROBERTAGNOLLI.pdf.txtExtracted texttext/plain335312http://repositorio.ufsm.br/bitstream/1/4166/2/DENISEDECASTROBERTAGNOLLI.pdf.txt3ac0be1b468df1cd9ea4fa11a1aaf972MD52THUMBNAILDENISEDECASTROBERTAGNOLLI.pdf.jpgDENISEDECASTROBERTAGNOLLI.pdf.jpgIM Thumbnailimage/jpeg4690http://repositorio.ufsm.br/bitstream/1/4166/3/DENISEDECASTROBERTAGNOLLI.pdf.jpg35d11962e58133b3415731b20f50cc93MD531/41662023-04-13 09:41:39.964oai:repositorio.ufsm.br:1/4166Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2023-04-13T12:41:39Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Migração de metais por interação das embalagens com soluções parenterais |
dc.title.alternative.eng.fl_str_mv |
Migration of metals by the interaction of packages with pararenteral solutions |
title |
Migração de metais por interação das embalagens com soluções parenterais |
spellingShingle |
Migração de metais por interação das embalagens com soluções parenterais Bertagnolli, Denise de Castro Nutrição parenteral Embalagens plásticas Embalagens de vidro Parenteral nutrition Plastic containers Glass containers CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Migração de metais por interação das embalagens com soluções parenterais |
title_full |
Migração de metais por interação das embalagens com soluções parenterais |
title_fullStr |
Migração de metais por interação das embalagens com soluções parenterais |
title_full_unstemmed |
Migração de metais por interação das embalagens com soluções parenterais |
title_sort |
Migração de metais por interação das embalagens com soluções parenterais |
author |
Bertagnolli, Denise de Castro |
author_facet |
Bertagnolli, Denise de Castro |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Nascimento, Denise Bohrer do |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9817093263802769 |
dc.contributor.referee1.fl_str_mv |
Cardoso, Simone Gonçalves |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/0137281979458686 |
dc.contributor.referee2.fl_str_mv |
Limberger, Renata Pereira |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7116144690986974 |
dc.contributor.referee3.fl_str_mv |
Emanuelli, Tatiana |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/2165391096880394 |
dc.contributor.referee4.fl_str_mv |
Carvalho, Leandro Machado de |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/6652387343920028 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6727744713310620 |
dc.contributor.author.fl_str_mv |
Bertagnolli, Denise de Castro |
contributor_str_mv |
Nascimento, Denise Bohrer do Cardoso, Simone Gonçalves Limberger, Renata Pereira Emanuelli, Tatiana Carvalho, Leandro Machado de |
dc.subject.por.fl_str_mv |
Nutrição parenteral Embalagens plásticas Embalagens de vidro |
topic |
Nutrição parenteral Embalagens plásticas Embalagens de vidro Parenteral nutrition Plastic containers Glass containers CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Parenteral nutrition Plastic containers Glass containers |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
The administration of medication and nutrients via parenteral is very used nowadays. One of the risks of this procedure is the presence of contaminants, which depending on their nature may cause severe damage to the patients due to the direct way of the administration (in the circulatory stream). In this work we investigated the possibility of the containers to be sources of metals for solutions of parenteral nutrition. The investigated containers are made of different kinds of glass and plastic polymers, namely polypropylene, PVC and EVA. The system container/solution (amino acids, salts, glucose and lipids) individually stored, was submitted to the sterilization process and after that stored for a time period of approximately 10 months, since the shelf-life period of these formulations are generally 2 years. After the sterilization and at regular time intervals, aliquots of each solution were collected and their contents on Al, Pb, Cd, Fe, Cr, Mn, Ba, and Zn were measured by graphite furnace atomic absorption spectrometry. The containers were also analyzed for the determination of the amount of each metal they contained. These metals are either constituents of the container material, as Al in glasses, or impurities in the case of plastic polymers. All containers presented the metals investigated. The solutions, depending on their composition (species dissolved) were able to extract the metals either from the glass or the polymers. The highest extraction rates occurred in solutions of the amino acids cysteine and glutamic acid, and in solutions of NaHCO3. The metals released in higher concentration were Ba, Pb and Zn form plastic containers and Al, Pb and Zn form glass containers. A different behavior was observed among the plastic polymers, and the different kinds of glass. While EVA was the most inert polymer, the clear glass ampoule released the highest amount of metals into the solutions. Fifty commercial samples were analyzed as well, and the investigated metals were found in all of them. The commercial formulations presented the same tendency of the individual sample used in the study, either in relation to the behavior of the substance in solution or the container material. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-06-19 |
dc.date.accessioned.fl_str_mv |
2017-05-15 |
dc.date.available.fl_str_mv |
2017-05-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BERTAGNOLLI, Denise de Castro. Migration of metals by the interaction of packages with pararenteral solutions. 2008. 258 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2008. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/4166 |
identifier_str_mv |
BERTAGNOLLI, Denise de Castro. Migration of metals by the interaction of packages with pararenteral solutions. 2008. 258 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2008. |
url |
http://repositorio.ufsm.br/handle/1/4166 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
100600000000 |
dc.relation.confidence.fl_str_mv |
400 500 300 300 300 500 300 |
dc.relation.authority.fl_str_mv |
1c5af0ad-15cf-4a7e-9b25-b8b6b1363ae6 70776a36-aae3-4f93-bfba-9ea048388fb1 d74914cc-c0c9-4458-b1af-49d276dd86ae 0502dec6-ae3d-4c37-850e-2b7c6c6cba64 7457e618-e257-4f1d-b319-f58982632184 369e0f2d-1b60-4076-ac06-58a85a76f15b |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Química |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Química |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações do UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Biblioteca Digital de Teses e Dissertações do UFSM |
collection |
Biblioteca Digital de Teses e Dissertações do UFSM |
bitstream.url.fl_str_mv |
http://repositorio.ufsm.br/bitstream/1/4166/1/DENISEDECASTROBERTAGNOLLI.pdf http://repositorio.ufsm.br/bitstream/1/4166/2/DENISEDECASTROBERTAGNOLLI.pdf.txt http://repositorio.ufsm.br/bitstream/1/4166/3/DENISEDECASTROBERTAGNOLLI.pdf.jpg |
bitstream.checksum.fl_str_mv |
a74f50f358379fe70b78a07bcdbe121d 3ac0be1b468df1cd9ea4fa11a1aaf972 35d11962e58133b3415731b20f50cc93 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1793240037297487872 |