Acilenaminonas: síntese e aplicação na obtenção de pirazóis, pirazolo[3,4-d]piridazinonas e pirazolo[1,5-a]pirimidinas

• Ano de defesa: 2009
• Autor(a) principal: Rosa, Fernanda Andreia
• Orientador(a): Martins, Marcos Antonio Pinto
• Banca de defesa: Zanatta, Nilo , Bonacorso, Helio Gauze , Lenardao, Eder Joao , Zoch, Alana Neto
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria
• Programa de Pós-Graduação: Programa de Pós-Graduação em Química
• Departamento: Química
• País: BR
• Palavras-chave em Português: Enonas; Acilação; Regiosseletividade; Enaminodicetonas; Ciclocondensação; Pirazóis; Pirazolo[3,4-d]piridazinonas; Pirazolo[1,5-a]pirimidinas
• Palavras-chave em Inglês: Enones; Acylation; Regioselectivity; Ciclocondensation; Pyrazoles; Pyrazolo[3,4d]pyridazinones; Pyrazolo[1,5-a]pyrimidines
• Área do conhecimento CNPq: CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
• Link de acesso: http://repositorio.ufsm.br/handle/1/4174

The regioespecific synthesis of a series of 14 N-acylated enaminones (52-88%) from the acylation reaction of secondary β-enamino ketones [RC(O)CH=CHNR1R2; R = Ph, 4- FC6H4, 4-NO2C6H4, thien-2-yl, CCl3, CF3; R1 = H; R2 = Bn, Ph, 4-NO2C6H4] with trifluoroacetic anhydride or ethyl oxalyl chloride in pyridine is reported. On the other hand, when tertiary enaminone precursors [R = Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, 4-ClC6H4, 4-FC6H4, 4-O2NC6H4, thien-2-yl, benzofur-2-yl, CCl3, CF3; R1,R2 = Me] were used, the acylation reaction led to a series of 17 C-acylated enaminones (75-95%). A series of 4-substituted-1H-pyrazole-5-carboxylates (73-94%) were obtained regiospecifically from the cyclocondensation reaction of non symmetrical enaminodiketones [RC(O)C(=CHNMe2)C(O)CO2Et; R = Ph, 4-MeOC6H4, 4-ClC6H4, 4-FC6H4, 4-O2NC6H4, thien-2-yl, benzofur-2-yl, CCl3, CF3] with tert-butylhydrazine or carboxymethylhydrazine. The reaction of these pyrazole-5-carboxylates (R = 4-MeOC6H4, 4-FC6H4, benzofur-2-yl, CF3) with hydrazine lead to synthesis of 4- substituted-pyrazolo[3,4-d]pyridazinones (74-96%). In addition, the reaction of enaminodiketones (R = Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, 4-ClC6H4, 4-FC6H4, 4- O2NC6H4, thien-2-yl, benzofur-2-yl) with 3-amino-5-methylpyrazole was performed, where a series of pyrazolo[1,5-a]pyrimidine-7-carboxylates were obtained regiospecifically (53-79%).