Nutrição e metabolismo ósseo

• Ano de defesa: 2019
• Autor(a) principal: Brondani, Juliana Ebling
• Orientador(a): Premaor, Melissa Orlandin
• Banca de defesa: Schuch, Natielen Jacques , Colpo, Elisângela , Dallepiane, Loiva Beatriz , Bochi, Guilherme Vargas
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; Centro de Ciências da Saúde
• Programa de Pós-Graduação: Programa de Pós-Graduação em Farmacologia
• Departamento: Farmacologia
• País: Brasil
• Palavras-chave em Português: Frutas; Hortaliças; Ossos; Fraturas ósseas; Metanálise; Vitamina D. pós-menopausa; Qualidade de vida; SF-36; Atenção primária; Humanos
• Palavras-chave em Inglês: Fruit; Vegetables; Bone; Meta-analysis; Vitamin D; Postmenopausal; Quality of life; Primary care; Humans; Fractures
• Área do conhecimento CNPq: CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/18848

Although intake of fruits and vegetables seemed to have a protective effect on bone metabolism, its effect on fractures remains uncertain. Some studies have described an impairment in quality of life of vitamin-deficient subjects D. However, little is known about this association in primary care. This study aimed to assess whether the regular intake of fruits and vegetables has significant effects on bone health, and evaluate the association between vitamin D deficiency and quality of life in postmenopausal women attending primary care. First, a systematic review of randomized controlled trials (RCTs) and cohort studies (PROSPERO: CRD42016041462) was performed. RCTs and cohort studies that evaluated the combined intake of fruits and vegetables in men and women aged over 50 years were included. We considered fractures as a primary outcome measure. Changes in bone markers were considered as secondary outcomes. The search strategy included the following descriptors: fruit, vegetables, vegetable products, bone and bones, bone fractures, postmenopausal osteoporosis, and osteoporosis. PubMed, Embase, and Cochrane Library were the databases used. The appraisal of the studies was performed by two independent reviewers, and discussed and agreed upon by both examiners. The data extracted from the RCTs and cohort studies were summarized separately. The risks of fractures were combined across studies using random models. Bone resorption marker (CTx) was summarized with standardized mean differences. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) method was used to evaluate the strength of recommendations. Of the 1,192 studies screened, 13 articles were included in the systematic review and 10 were included in the pooled analysis (6 cohort studies and 4 RCTs). The six cohort studies included in the meta-analysis included a population of 225,062. The pooled hazard ratio (HR) (95% confidence interval (CI)) of the hip in five studies was 0.92 (0.87, 0.98). Its heterogeneity was moderate (I2 = 55.7%, p = 0.060), GRADE (⊕⊕⊕O). Two cohort studies evaluated the risk of any fracture; the HR was 0.90 (95% CI: 0.86–0.96), with aheterogeneity of 24.9% (p = 0.249, GRADE (⊕⊕⊕O)). There was no association between the bone resorption marker CTx and 3 months of fruit and vegetable intake evaluated by four RCTs, GRADE (⊕⊕O O). There was an association between the increase intake of at least one serving of fruits and vegetables per day and decreases in the risk of fractures. The level of evidence for this association is moderate. In the second study, a cross-sectional study was carried out with postmenopausal women over 55 years of age, accompanied in primary care, from March to August 2014. These women were randomly selected among the participants of an ongoing cohort study in the municipality of Santa Maria - Brazil. Data were collected through a standardized questionnaire, quality of life was assessed using the Short Form-36 Health Survey (SF-36), and 25-hydroxyvitamin D were measured using the ALPCO® ELISA method. Of the total of 78 studied women, 11.54% had vitamin D deficiency. Women with vitamin D deficiency had a poorer quality of life assessed by SF-36. In the regression analysis, both vitamin D deficiency and falls were independently associated with a lower physical component of the SF-36. Vitamin D deficiency is associated with poorer quality of life in the studied postmenopausal women.