Arquiteturas de autoassociação derivadas de piridoxal e dihidrazidas: síntese e avaliações espectroscópicas e teóricas de interação com DNA

Detalhes bibliográficos
Ano de defesa: 2019
Autor(a) principal: Martins, Francisco Mainardi lattes
Orientador(a): Back, Davi Fernando lattes
Banca de defesa: Squizani, Fatima lattes, Vargas, Jaqueline Pinto lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Santa Maria
Centro de Ciências Naturais e Exatas
Programa de Pós-Graduação: Programa de Pós-Graduação em Química
Departamento: Química
País: Brasil
Palavras-chave em Português:
Piridoxal
Metais de transição
Arquiteturas de autoassociação
Interação com DNA
Palavras-chave em Inglês:
Pyridoxal
Transition metals
Self-assembly architectures
Interaction with DNA
Área do conhecimento CNPq:
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
Link de acesso: http://repositorio.ufsm.br/handle/1/19355
Resumo: This work is about the synthesis of bis-azomethine ligands of Schiff type derived from pyridoxal and aliphatic dihydrazides and the subsequent synthesis of complexes of various transition metals containing such ligands. The ligands and synthesized complexes had their structures elucidated by single-crystal X-ray diffraction and were characterized by vibrational spectroscopies (Raman and infrared) and by ultravioletvisible spectroscopy. These ligands have characteristics, such as flexibility or rigidity, which allow the formation of self-assembly processes. The metal centers employed have different chemical affinities. These differences between the ligands and between the metal centers lead to the formation of self-assembly architectures with distinct structures. Eight structurally different complexes were obtained from salts of dioxidevanadium(V), cobalt(III), nickel(II) and zinc(II). The ligands and complexes synthesized had their interactions with ct-DNA evaluated by ultraviolet-visible Spectroscopy and by photoluminescence spectroscopy. The ligands and nickel(II) complexes had their interactions with DNA evaluated, also, by theoretical studies of molecular docking.
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spelling 2020-01-14T11:52:22Z2020-01-14T11:52:22Z2019-08-02http://repositorio.ufsm.br/handle/1/19355This work is about the synthesis of bis-azomethine ligands of Schiff type derived from pyridoxal and aliphatic dihydrazides and the subsequent synthesis of complexes of various transition metals containing such ligands. The ligands and synthesized complexes had their structures elucidated by single-crystal X-ray diffraction and were characterized by vibrational spectroscopies (Raman and infrared) and by ultravioletvisible spectroscopy. These ligands have characteristics, such as flexibility or rigidity, which allow the formation of self-assembly processes. The metal centers employed have different chemical affinities. These differences between the ligands and between the metal centers lead to the formation of self-assembly architectures with distinct structures. Eight structurally different complexes were obtained from salts of dioxidevanadium(V), cobalt(III), nickel(II) and zinc(II). The ligands and complexes synthesized had their interactions with ct-DNA evaluated by ultraviolet-visible Spectroscopy and by photoluminescence spectroscopy. The ligands and nickel(II) complexes had their interactions with DNA evaluated, also, by theoretical studies of molecular docking.Este trabalho aborda a síntese de ligantes base de Schiff bis-azometina derivados de piridoxal e dihidrazidas alifáticas e a posterior síntese de complexos de diversos metais de transição contendo tais ligantes. As estruturas moleculares dos ligantes e complexos foram elucidadas por difração de raios X em monocristal e foram caracterizados por espectroscopias vibracionais no infravermelho e Raman e por espectroscopia de absorção eletrônica na região do UV/Vis. Esses ligantes sintetizados apresentam estruturas opostas, com alguns apresentando flexibilidade e outro rigidez, propiciando a formação de processos de autoassociação. Os centros metálicos empregados apresentam diferentes afinidades químicas. Essas diferenças entre os ligantes e entre os centros metálicos levam à formação de arquiteturas de autoassociação com estruturas distintas. Foram obtidos oito complexos estruturalmente distintos a partir de sais de dioxidovanádio(V), de cobalto(III), de níquel(II) e de zinco(II). Os ligantes e complexos sintetizados tiveram suas interações com ct-DNA avaliadas por espectroscopia de absorção eletrônica na região do UV/Vis e por espectroscopia de fotoluminescência. Os ligantes e complexos de níquel(II) tiveram suas interações com DNA avaliadas, também, por estudos teóricos de docking molecular.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESporUniversidade Federal de Santa MariaCentro de Ciências Naturais e ExatasPrograma de Pós-Graduação em QuímicaUFSMBrasilQuímicaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessPiridoxalMetais de transiçãoArquiteturas de autoassociaçãoInteração com DNAPyridoxalTransition metalsSelf-assembly architecturesInteraction with DNACNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICAArquiteturas de autoassociação derivadas de piridoxal e dihidrazidas: síntese e avaliações espectroscópicas e teóricas de interação com DNASelf-assemblies derived from pyridoxal and dihydrazides: synthesis and spectroscopic and theoretical evaluations of interaction with DNAinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisBack, Davi Fernandohttp://lattes.cnpq.br/3778138554788107Squizani, Fatimahttp://lattes.cnpq.br/1060502818943139Vargas, Jaqueline Pintohttp://lattes.cnpq.br/2927700876012801http://lattes.cnpq.br/5113388966744397Martins, Francisco Mainardi1006000000006006028c486-84b0-44fc-aa73-1e49cc9c8fbb9f1a74e4-b4e6-403c-bdb0-dca62d73a126ac190e33-507d-45e7-a331-80a538d9dc800bde100a-e8ed-45e0-8c25-fa6924a52dbbreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGQUIMICA_2019_MARTINS_FRANCISCO.pdfDIS_PPGQUIMICA_2019_MARTINS_FRANCISCO.pdfDissertação de Mestradoapplication/pdf8926193http://repositorio.ufsm.br/bitstream/1/19355/1/DIS_PPGQUIMICA_2019_MARTINS_FRANCISCO.pdf1d7271e332c5bcbfbc95df982e82e91bMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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dc.title.por.fl_str_mv Arquiteturas de autoassociação derivadas de piridoxal e dihidrazidas: síntese e avaliações espectroscópicas e teóricas de interação com DNA
dc.title.alternative.eng.fl_str_mv Self-assemblies derived from pyridoxal and dihydrazides: synthesis and spectroscopic and theoretical evaluations of interaction with DNA
title Arquiteturas de autoassociação derivadas de piridoxal e dihidrazidas: síntese e avaliações espectroscópicas e teóricas de interação com DNA
spellingShingle Arquiteturas de autoassociação derivadas de piridoxal e dihidrazidas: síntese e avaliações espectroscópicas e teóricas de interação com DNA
Martins, Francisco Mainardi
Piridoxal
Metais de transição
Arquiteturas de autoassociação
Interação com DNA
Pyridoxal
Transition metals
Self-assembly architectures
Interaction with DNA
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
title_short Arquiteturas de autoassociação derivadas de piridoxal e dihidrazidas: síntese e avaliações espectroscópicas e teóricas de interação com DNA
title_full Arquiteturas de autoassociação derivadas de piridoxal e dihidrazidas: síntese e avaliações espectroscópicas e teóricas de interação com DNA
title_fullStr Arquiteturas de autoassociação derivadas de piridoxal e dihidrazidas: síntese e avaliações espectroscópicas e teóricas de interação com DNA
title_full_unstemmed Arquiteturas de autoassociação derivadas de piridoxal e dihidrazidas: síntese e avaliações espectroscópicas e teóricas de interação com DNA
title_sort Arquiteturas de autoassociação derivadas de piridoxal e dihidrazidas: síntese e avaliações espectroscópicas e teóricas de interação com DNA
author Martins, Francisco Mainardi
author_facet Martins, Francisco Mainardi
author_role author
dc.contributor.advisor1.fl_str_mv Back, Davi Fernando
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3778138554788107
dc.contributor.referee1.fl_str_mv Squizani, Fatima
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/1060502818943139
dc.contributor.referee2.fl_str_mv Vargas, Jaqueline Pinto
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/2927700876012801
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/5113388966744397
dc.contributor.author.fl_str_mv Martins, Francisco Mainardi
contributor_str_mv Back, Davi Fernando
Squizani, Fatima
Vargas, Jaqueline Pinto
dc.subject.por.fl_str_mv Piridoxal
Metais de transição
Arquiteturas de autoassociação
Interação com DNA
topic Piridoxal
Metais de transição
Arquiteturas de autoassociação
Interação com DNA
Pyridoxal
Transition metals
Self-assembly architectures
Interaction with DNA
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
dc.subject.eng.fl_str_mv Pyridoxal
Transition metals
Self-assembly architectures
Interaction with DNA
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
description This work is about the synthesis of bis-azomethine ligands of Schiff type derived from pyridoxal and aliphatic dihydrazides and the subsequent synthesis of complexes of various transition metals containing such ligands. The ligands and synthesized complexes had their structures elucidated by single-crystal X-ray diffraction and were characterized by vibrational spectroscopies (Raman and infrared) and by ultravioletvisible spectroscopy. These ligands have characteristics, such as flexibility or rigidity, which allow the formation of self-assembly processes. The metal centers employed have different chemical affinities. These differences between the ligands and between the metal centers lead to the formation of self-assembly architectures with distinct structures. Eight structurally different complexes were obtained from salts of dioxidevanadium(V), cobalt(III), nickel(II) and zinc(II). The ligands and complexes synthesized had their interactions with ct-DNA evaluated by ultraviolet-visible Spectroscopy and by photoluminescence spectroscopy. The ligands and nickel(II) complexes had their interactions with DNA evaluated, also, by theoretical studies of molecular docking.
publishDate 2019
dc.date.issued.fl_str_mv 2019-08-02
dc.date.accessioned.fl_str_mv 2020-01-14T11:52:22Z
dc.date.available.fl_str_mv 2020-01-14T11:52:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufsm.br/handle/1/19355
url http://repositorio.ufsm.br/handle/1/19355
dc.language.iso.fl_str_mv por
language por
dc.relation.cnpq.fl_str_mv 100600000000
dc.relation.confidence.fl_str_mv 600
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dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
Centro de Ciências Naturais e Exatas
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Química
dc.publisher.initials.fl_str_mv UFSM
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Química
publisher.none.fl_str_mv Universidade Federal de Santa Maria
Centro de Ciências Naturais e Exatas
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações do UFSM
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Biblioteca Digital de Teses e Dissertações do UFSM
collection Biblioteca Digital de Teses e Dissertações do UFSM
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