Quantificação do alumínio administrado e excretado em recém-nascidos pré-termo em uma unidade de terapia intensiva neonatal
Ano de defesa: | 2008 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Química
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/10437 |
Resumo: | Al is a ubiquitous element on the earth crust and is considered a non-essential element for humans since it is not involved in any biochemical process. Aluminum may act as a toxic species when it is introduced directly into the circulatory system. The most exposed patients are those receiving parenteral nutrition, mainly pre-term infants with less than 37 gestational weeks, under total parenteral nutrition. Due to organs immaturity, pre-term infants are vulnerable to the toxic effects of aluminum. The intoxication is related to symptoms such as anemia, bone disease and neurological disturbances. During the period that the patients are under intensive care, they receive nutrients and medication through the parenteral via. Infusion solutions and solutions for parenteral nutrition may be contaminated by aluminum and therefore be a source of this element to babies. This study aimed to evaluate the extent of the contamination of parenteral solutions and medications administered to patients as well as to establish a balance between the aluminum administered together with the parenteral infusion and eliminated by the babies through the urine. For this evaluation, 10 new-born babies, presenting normal renal function and aging from 32 to 36 gestational weeks were selected, independent of sex. All medication, infusion and nutritional solutions, administered to these babies were collected. Daily urine samples of each baby were also collected, as well as the blood at the first and last day in the intensive care unit. The commercial solutions that were used to 12 compound the nutritional solution administered to the patients were also analyzed. The determination of aluminum was carried out by atomic absorption spectrometry. Results showed that all components of solutions for parenteral nutrition were contaminated by aluminum. While infusion solutions (glucose, NaCl 0.9% and Ringer Lactate) presented a mean of 20 μg/L Al, in bags containing nutritional components the Al level was 500 μg/L. Infusion sets (burette and tubing system) increased in 20% the aluminum in the fluid being administered to the patient. The same was observed for the medication, dilution and administration by means of syringes increased the aluminum present in these samples. The balance between the Al administered and excreted by the new-born babies showed that approximately 58% of the Al is not eliminated in the urine. Moreover, 50% of the patients ingested more than 5 μg Al/kg/day, which is the limit recommended by the US Food and Drug Administration (FDA) for patients under total parenteral nutrition. Since the Al in the patient s blood practically did not change between the first and the last day of internment, the noneliminated Al must have been deposited in any part of the patient s body. |
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2017-05-252017-05-252008-10-15OLIVEIRA, Sandra Maria Ribeiro de. Quantification of aluminum administered and excreted by babies born pre-term in a neonatal intensive care unit. 2008. 102 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2008.http://repositorio.ufsm.br/handle/1/10437Al is a ubiquitous element on the earth crust and is considered a non-essential element for humans since it is not involved in any biochemical process. Aluminum may act as a toxic species when it is introduced directly into the circulatory system. The most exposed patients are those receiving parenteral nutrition, mainly pre-term infants with less than 37 gestational weeks, under total parenteral nutrition. Due to organs immaturity, pre-term infants are vulnerable to the toxic effects of aluminum. The intoxication is related to symptoms such as anemia, bone disease and neurological disturbances. During the period that the patients are under intensive care, they receive nutrients and medication through the parenteral via. Infusion solutions and solutions for parenteral nutrition may be contaminated by aluminum and therefore be a source of this element to babies. This study aimed to evaluate the extent of the contamination of parenteral solutions and medications administered to patients as well as to establish a balance between the aluminum administered together with the parenteral infusion and eliminated by the babies through the urine. For this evaluation, 10 new-born babies, presenting normal renal function and aging from 32 to 36 gestational weeks were selected, independent of sex. All medication, infusion and nutritional solutions, administered to these babies were collected. Daily urine samples of each baby were also collected, as well as the blood at the first and last day in the intensive care unit. The commercial solutions that were used to 12 compound the nutritional solution administered to the patients were also analyzed. The determination of aluminum was carried out by atomic absorption spectrometry. Results showed that all components of solutions for parenteral nutrition were contaminated by aluminum. While infusion solutions (glucose, NaCl 0.9% and Ringer Lactate) presented a mean of 20 μg/L Al, in bags containing nutritional components the Al level was 500 μg/L. Infusion sets (burette and tubing system) increased in 20% the aluminum in the fluid being administered to the patient. The same was observed for the medication, dilution and administration by means of syringes increased the aluminum present in these samples. The balance between the Al administered and excreted by the new-born babies showed that approximately 58% of the Al is not eliminated in the urine. Moreover, 50% of the patients ingested more than 5 μg Al/kg/day, which is the limit recommended by the US Food and Drug Administration (FDA) for patients under total parenteral nutrition. Since the Al in the patient s blood practically did not change between the first and the last day of internment, the noneliminated Al must have been deposited in any part of the patient s body.O alumínio é um metal onipresente na crosta terrestre, é considerado não essencial, porque não participa de nenhum processo bioquímico. Devido a imaturidade dos órgãos e principalmente do sistema renal, o alumínio poderá ser tóxico aos recém-nascidos pré-termos. Recém-nascidos prematuros ou pré-termos são aqueles que nascem com menos de 37 semanas de idade gestacional. Os principais problemas toxicológicos do alumínio estão relacionados a neurotoxicidade, hepatoxicidade, doença do metabolismo ósseo, além de distúrbios hematológicos, como a anemia microcítica hipocrômica. Durante o período de internação, pacientes prematuros recebem nutrientes e medicações através da via parenteral. Soluções para infusão e para nutrição parenteral podem se apresentar contaminadas por alumínio e desta forma ser uma fonte deste elemento para os prematuros. Este estudo teve por finalidade avaliar as soluções parenterais, medicações injetáveis, fluidos biológicos e estabelecer um balanço do alumínio que é administrado e excretado por via renal pelos recém-nascidos. Para esta avaliação foram selecionados dez recém-nascidos pré-termo com 32 a 36 semanas e 6 dias de idade gestacional, independentes do sexo e com função renal normal. Foram coletadas amostras de medicamentos, seringas de administração e bolsas de infusão parenteral. Amostras de urina foram coletadas diariamente. Amostras de soro foram coletadas no primeiro e último dia de internação. Foram analisados além das bolsas de infusão parenteral os componentes que fazem parte de sua composição. Toda a medicação injetável utilizada pelos recém-nascidos foi analisada e também os diluentes que fazem parte de sua preparação. A concentração de alumínio em todas as amostras foi determinada pela técnica de espectrometria de absorção atômica (AAS). Os resultados mostraram que as soluções de nutrição parenteral são as mais contaminadas por alumínio, sendo que a presença do dispositivo de administração, conhecido como bureta, aumenta consideravelmente o teor deste metal no fluido que está sendo administrado ao paciente. As amostras de medicamentos apresentam elevada contaminação por alumínio, no entanto, o fato da administração ser feita através de seringas, o nível de Al nestas amostras aumentou significativamente. O balanço do alumínio administrado e excretado aos recémnascidos pré-termos mostrou que em média 58% do alumínio administrado não é eliminado na urina, e que 50% dos recém-nascidos pré-termos ingerem mais do que 5 μg Al/kg/dia, este valor encontra-se acima do limite estabelecido pela Food and Drug Administration (FDA) para pacientes pediátricos. Como o nível de Al no sangue dos pacientes praticamente não se alterou entre o primeiro e o último dia de internação, o Al não eliminado deve ter se depositado em alguma parte do corpo do paciente.application/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em QuímicaUFSMBRQuímicaAlumínioRecém-nascido pré-termoUTI neonatalNutrição parenteralAluminumBabies born pre-termNeonatal intensive care unitParenteral nutritionCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICAQuantificação do alumínio administrado e excretado em recém-nascidos pré-termo em uma unidade de terapia intensiva neonatalQuantification of aluminum administered and excreted by babies born pre-term in a neonatal intensive care unitinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisNascimento, Denise Bohrer dohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4798557Z7Schetinger, Maria Rosa ChitolinaMortari, Sergio Robertohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4721640J6http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4704791T3Oliveira, Sandra Maria Ribeiro de1006000000004005003005005001c5af0ad-15cf-4a7e-9b25-b8b6b1363ae62b94d9d7-24d6-446d-8b9d-f1fdb5d5f572cba4a833-b1c5-4608-8453-7a46f671faf13c621a6d-38be-4e61-b644-40b0cc92afcbinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALSANDRAMARIARIBEIRODEOLIVEIRA.pdfapplication/pdf643326http://repositorio.ufsm.br/bitstream/1/10437/1/SANDRAMARIARIBEIRODEOLIVEIRA.pdf5e77a84f50cc1f113c6590dc2edbbcd1MD51TEXTSANDRAMARIARIBEIRODEOLIVEIRA.pdf.txtSANDRAMARIARIBEIRODEOLIVEIRA.pdf.txtExtracted texttext/plain141719http://repositorio.ufsm.br/bitstream/1/10437/2/SANDRAMARIARIBEIRODEOLIVEIRA.pdf.txt06aeb99507a7fb4578527d8e6b8c5fa7MD52THUMBNAILSANDRAMARIARIBEIRODEOLIVEIRA.pdf.jpgSANDRAMARIARIBEIRODEOLIVEIRA.pdf.jpgIM Thumbnailimage/jpeg5708http://repositorio.ufsm.br/bitstream/1/10437/3/SANDRAMARIARIBEIRODEOLIVEIRA.pdf.jpg36ddc997b5c1abf627aec77209580746MD531/104372017-07-25 12:05:08.237oai:repositorio.ufsm.br:1/10437Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2017-07-25T15:05:08Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Quantificação do alumínio administrado e excretado em recém-nascidos pré-termo em uma unidade de terapia intensiva neonatal |
dc.title.alternative.eng.fl_str_mv |
Quantification of aluminum administered and excreted by babies born pre-term in a neonatal intensive care unit |
title |
Quantificação do alumínio administrado e excretado em recém-nascidos pré-termo em uma unidade de terapia intensiva neonatal |
spellingShingle |
Quantificação do alumínio administrado e excretado em recém-nascidos pré-termo em uma unidade de terapia intensiva neonatal Oliveira, Sandra Maria Ribeiro de Alumínio Recém-nascido pré-termo UTI neonatal Nutrição parenteral Aluminum Babies born pre-term Neonatal intensive care unit Parenteral nutrition CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Quantificação do alumínio administrado e excretado em recém-nascidos pré-termo em uma unidade de terapia intensiva neonatal |
title_full |
Quantificação do alumínio administrado e excretado em recém-nascidos pré-termo em uma unidade de terapia intensiva neonatal |
title_fullStr |
Quantificação do alumínio administrado e excretado em recém-nascidos pré-termo em uma unidade de terapia intensiva neonatal |
title_full_unstemmed |
Quantificação do alumínio administrado e excretado em recém-nascidos pré-termo em uma unidade de terapia intensiva neonatal |
title_sort |
Quantificação do alumínio administrado e excretado em recém-nascidos pré-termo em uma unidade de terapia intensiva neonatal |
author |
Oliveira, Sandra Maria Ribeiro de |
author_facet |
Oliveira, Sandra Maria Ribeiro de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Nascimento, Denise Bohrer do |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4798557Z7 |
dc.contributor.referee1.fl_str_mv |
Schetinger, Maria Rosa Chitolina |
dc.contributor.referee2.fl_str_mv |
Mortari, Sergio Roberto |
dc.contributor.referee2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4721640J6 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4704791T3 |
dc.contributor.author.fl_str_mv |
Oliveira, Sandra Maria Ribeiro de |
contributor_str_mv |
Nascimento, Denise Bohrer do Schetinger, Maria Rosa Chitolina Mortari, Sergio Roberto |
dc.subject.por.fl_str_mv |
Alumínio Recém-nascido pré-termo UTI neonatal Nutrição parenteral |
topic |
Alumínio Recém-nascido pré-termo UTI neonatal Nutrição parenteral Aluminum Babies born pre-term Neonatal intensive care unit Parenteral nutrition CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Aluminum Babies born pre-term Neonatal intensive care unit Parenteral nutrition |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
Al is a ubiquitous element on the earth crust and is considered a non-essential element for humans since it is not involved in any biochemical process. Aluminum may act as a toxic species when it is introduced directly into the circulatory system. The most exposed patients are those receiving parenteral nutrition, mainly pre-term infants with less than 37 gestational weeks, under total parenteral nutrition. Due to organs immaturity, pre-term infants are vulnerable to the toxic effects of aluminum. The intoxication is related to symptoms such as anemia, bone disease and neurological disturbances. During the period that the patients are under intensive care, they receive nutrients and medication through the parenteral via. Infusion solutions and solutions for parenteral nutrition may be contaminated by aluminum and therefore be a source of this element to babies. This study aimed to evaluate the extent of the contamination of parenteral solutions and medications administered to patients as well as to establish a balance between the aluminum administered together with the parenteral infusion and eliminated by the babies through the urine. For this evaluation, 10 new-born babies, presenting normal renal function and aging from 32 to 36 gestational weeks were selected, independent of sex. All medication, infusion and nutritional solutions, administered to these babies were collected. Daily urine samples of each baby were also collected, as well as the blood at the first and last day in the intensive care unit. The commercial solutions that were used to 12 compound the nutritional solution administered to the patients were also analyzed. The determination of aluminum was carried out by atomic absorption spectrometry. Results showed that all components of solutions for parenteral nutrition were contaminated by aluminum. While infusion solutions (glucose, NaCl 0.9% and Ringer Lactate) presented a mean of 20 μg/L Al, in bags containing nutritional components the Al level was 500 μg/L. Infusion sets (burette and tubing system) increased in 20% the aluminum in the fluid being administered to the patient. The same was observed for the medication, dilution and administration by means of syringes increased the aluminum present in these samples. The balance between the Al administered and excreted by the new-born babies showed that approximately 58% of the Al is not eliminated in the urine. Moreover, 50% of the patients ingested more than 5 μg Al/kg/day, which is the limit recommended by the US Food and Drug Administration (FDA) for patients under total parenteral nutrition. Since the Al in the patient s blood practically did not change between the first and the last day of internment, the noneliminated Al must have been deposited in any part of the patient s body. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-10-15 |
dc.date.accessioned.fl_str_mv |
2017-05-25 |
dc.date.available.fl_str_mv |
2017-05-25 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Sandra Maria Ribeiro de. Quantification of aluminum administered and excreted by babies born pre-term in a neonatal intensive care unit. 2008. 102 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2008. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/10437 |
identifier_str_mv |
OLIVEIRA, Sandra Maria Ribeiro de. Quantification of aluminum administered and excreted by babies born pre-term in a neonatal intensive care unit. 2008. 102 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2008. |
url |
http://repositorio.ufsm.br/handle/1/10437 |
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