Encapsulamento de moléculas bioativas com calix[n]arenos e avaliação da atividade fitotóxica de complexos de inclusão com aldiminas

• Ano de defesa: 2009
• Autor(a) principal: Tavares, Eder do Couto
• Orientador(a): Fernandes, Sergio Antônio
• Banca de defesa: Demuner, Antônio Jacinto , Teixeira, Róbson Ricardo , Fátima, ângelo de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Viçosa
• Programa de Pós-Graduação: Mestrado em Agroquímica
• Departamento: Agroquímica analítica; Agroquímica inorgânica e Físico-química; Agroquímica orgânica
• País: BR
• Palavras-chave em Português: Calixarenos; RMN; Atividade fitotóxica
• Palavras-chave em Inglês: Calixarenes; NMR; Phytotoxicity
• Área do conhecimento CNPq: CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA ORGANICA
• Link de acesso: http://locus.ufv.br/handle/123456789/2112

This research had as main objective to study intermolecular interactions using 1H NMR as major tool. The first chapter describes the synthesis of six molecules, two of them employed as molecular hosts: p-sulphonic acid calix[6]arene (SO3HCX[6]) (3) and p-sulphonic acid calix[4]arene (SO3HCX[4]) (6). The calixarenes synthesized were employed in the encapsulation of substances: retronecine (7), chloride prilocaine (8), chloride pramoxine (9), butyl-4- aminobenzoate (10), (E)-N-benzilideneaniline (11) e (E)-4-(phenylimine) metylphenol (12). Nevertheless, only 4 molecules had its study carried through for RMN of 1H. The molecules 9 and 10 could not be analyzed due to its precipitation, thus compromising the experiments. The topology of complexes retronecine/SO3HCX[6] and chloride prilocaine/SO3HCX[4] were determined. The stoichiometry of the complexes involving the aldimines (11) and (12) with p-sulphonic acid calix[6]arene were obtained, using the Job s Method. The second chapter describes the evaluation phytotoxic potential of the aldimines 11-14 as well as the effect of its encapsulation for the SO3HCX[6] and β-CD on this activity. 15 treatments and 1 white (water) with four repetitions in statistical delineation entirely randomized were evaluated. The evaluated characteristics were the root growth of seedlings of sorghum and cucumber, gain of biomass of the root and aerial part of sorghum and cucumber and the percentage of inhibition of these plants in relation to the white treatment. The formulation TPX (0.15% Tween 80, pentan-3-one and 0.05% xylene 0.01%) did not show suitable for the solubilization of compounds 11-14. The formulations SO3HCX[6] and β-CD showed activity, the first being the most pronounced. The results showed that the effect of aldimines on the growth of these species depends on the formulation used.