Treinamento físico para portadores de HIV submetidos a HAART: efeitos sobre parâmetros antropométricos, hemodinâmicos, funcionais, imunológicos, bioquímicos e na qualidade de vida

• Ano de defesa: 2010
• Autor(a) principal: Mendes, Edmar Lacerda
• Orientador(a): Paula, Sérgio Oliveira de
• Banca de defesa: Orsatti, Fábio Lera , Oliveira, Leandro Licursi de
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Viçosa
• Programa de Pós-Graduação: Doutorado em Biologia Celular e Estrutural
• Departamento: Análises quantitativas e moleculares do Genoma; Biologia das células e dos tecidos
• País: BR
• Palavras-chave em Português: Exercício físico; HIV; HAART
• Palavras-chave em Inglês: Physical exercise; HIV; HAART
• Área do conhecimento CNPq: CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL
• Link de acesso: http://locus.ufv.br/handle/123456789/238

The use of highly active antiretroviral therapy (HAART) has improved the prognosis of HIV-infected individuals. However, HAART has been associated with the development of metabolic and fat distribution abnormalities, the HIV-associated lipodystrophy syndrome (SLHIV). Propose: This study investigated the impact of 24 weeks of resistance exercise with aerobic component (ERCA) on anthropometric, hemodynamic, functional, immunological, biochemical and quality of life in HIV-infected patients undergoing HAART. Methods: Ninety nine HIV-infected patients were randomly allocated into four groups: exercise and lipodystrophy (n = 24; EX + LIP); exercise without lipodystrophy (n = 21; EX + NoLIP); control and lipodystrophy (n = 27; NoEX + LIP); control without lipodystrophy (n = 27; NoEX + NoLIP). Subjects from exercised groups (EX+LIP and EX+NoLIP) participated in a 24 weeks program of ERCA. Anthropometric, hemodynamic, biochemical, immunovirologic, metabolic syndrome (MS), strength tests, cardiorespiratory fitness and quality of life were assessed at baseline and 24weeks after intervention. Results: Body circumferences (P < 0.0001)and waist-hip ratio (P = 0.017) changed after 24 weeks of ERCA in both exercised groups. The sum of seven skinfolds assessed, body fat percentage, fat body mass, and total, central and peripheral subcutaneous fat reduced (P < 0.0001) in response to ERCA. Lean body mass increased (P < 0.0001) in exercised groups, regardless of the outcome (LIP or NoLIP). Arterial blood pressure (P < 0.0001) and resting heart rate (P = 0.007) reduced in response to ERCA. Total cholesterol decreased (P = 0.024) only in EX+ NoLIP group. Levels of VLDL-c decreased (P = 0.012) in EX + LIP group. The immune responses did not change (P > 0.05) over 24 weeks ofintervention. The prevalence of MS decreased from 32.5% to 27.5% in all subjects. In exercised subjects, MS decreased from 39.5% to 26.3%. Strength, cardiorespiratory fitness and all six quality of life domains investigated increased (P < 0.0001) in both exercised groups in response to ERCA. Conclusion: 24 weeks of ERCA prevented the manifestation of changes arising from SLHIV and contributed to the reduction of these.