Efeitos do propofol, etomidato, tiopental e anestesia epidural em neonatos e em cadelas submetidas a cesariana eletiva

• Ano de defesa: 2003
• Autor(a) principal: Lavor, Mário Sérgio Lima de
• Orientador(a): Pompermayer, Luiz Gonzaga
• Banca de defesa: Borges, Andrea Pacheco Batista , Carlo, Ricardo Junqueira Del , Viana, José Antonio , Oliveira, Humberto Pereira
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Viçosa
• Programa de Pós-Graduação: Mestrado em Medicina Veterinária
• Departamento: Biotecnologia, diagnóstico e controle de doenças; Epidemiologia e controle de qualidade de prod. de
• País: BR
• Palavras-chave em Português: Anestesia; Cesariana; Depressão fetal
• Palavras-chave em Inglês: Anesthesia; Caesarian section; Neonatal depression
• Área do conhecimento CNPq: CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL::ANESTESIOLOGIA ANIMAL
• Link de acesso: http://locus.ufv.br/handle/123456789/5171

The caesarean section is an emergency procedure that should depend upon safe anaesthetic techniques for both the mother and foetus and, at the same time, allow the realization of the surgery in due time, freeing the puppies in a vigorous state. All of the anaesthetic drugs used in caesarians quickly cross through the placenta which can affect the foetus. Foetal and neonatal depression of a variable degree occurs following the anaesthetic induction, depending upon the induction agent used, its dosage and the time passed since the induction until the freeing of the foetus. On this study there is a comparison of the foetal and maternal effects of propofol, etomidate and thiopental used as anaesthesia induction drugs for the maintenance with halothane as well as a verification of the possible advantages in substituting these inducting drugs by epidural anesthesia, following direct induction with halotane administered through mask, in caesarean section in bitches. For so, 20 bitches and 129 puppies were used distributed in four groups. In group 1 ( 5 bitches and 39 newborns) the anaesthetic induction was made with propofol, in group 2 (5 bitches and 25 newborns) with etomidate, in group 3 (5 bitches and 26 newborns) with thiopental and in group 4 (5 bitches and 39 newborns) epidural anesthesia and induction with halothane through mask were used. In all the cases the pre-anaesthetic medication was made with midazolam in a dosage of 0,22 mg/kg IM, and the anaesthetic maintenance with halothane in a semiclosed circuit and a initial concentration of 3%. The evaluated variables on the bitches were: rectal temperature, heart rate, breath rate, oxi-hemoglobin (SpO2) saturation, sistolic, mean and diastolic blood arterial pressure. For the effect evaluation of the different techniques of anaesthetic induction, the newborns were measured for cardiac frequency, respiratory effort, muscular movement, mucosa coloration and reflex irritability, and interpreted through the modified Apgar score . Besides these variables, there was also the evaluation of the newborn's SpO2. The results showed that all of the protocols were adequate for the mothers with minimal systemic effects. For the newborn, epidural anaesthesia usage followed by induction and maintance with halothane was superior to the protocols that used injectable agents in the unaesthetic induction.