Histomorfometria de lesões agudas da mucosa gástrica de ratos Wistar induzidas por ácido acetilsalicílico, e os efeitos cicatrizantes do extrato aquoso do repolho (Brassica oleracea variedade capitata)

• Ano de defesa: 2009
• Autor(a) principal: Carvalho, Camilo Amaro de
• Orientador(a): Fonseca, Cláudio César
• Banca de defesa: Pinto, Rogerio , Rocha, Juliana Silva
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Viçosa
• Programa de Pós-Graduação: Mestrado em Biologia Celular e Estrutural
• Departamento: Análises quantitativas e moleculares do Genoma; Biologia das células e dos tecidos
• País: BR
• Palavras-chave em Português: Ácido acetilsalicílico; Brassica oleracea variedade capitata; Cicatrização; Úlcera gástrica
• Palavras-chave em Inglês: Acetylsalicylic acid; Brassica oleracea var. capitata; Cicatrization; Pepitic ulcer
• Área do conhecimento CNPq: CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL
• Link de acesso: http://locus.ufv.br/handle/123456789/2317

This work aimed at to investigate the healing effects of the aqueous extract of Brassica oleracea var. capitata (EAB), analyzing histological the ulcers induced by acetylsalicylic acid in animal model. They were appraised five treatments: 250, 500 and 1000 mg/kg of EAB, omeprazole to 20mg/kg and aqueous vehicle. The macroscopic and histological description of the stomach of mice was accomplished Wistar. It was verified that the the administration of the aqueous extract of Brassica oleracea var. capitata in the concentration of 1000mg/kg promoted better cicatrization tax, following for the omeprazole. However the treatment with EAB in the concentration of 1000mg/kg, in absolute values demonstrated to be the most effective for there being an additional improvement in the picture of the lesions, about 95,77% the more of reduction of the lesions when compared to the group treated with omeprazole. It is verified that the results are in agreement with the discoveries etnobotanicals and with other studies already accomplished with the Brassica sp., confirming like this his/her therapeutic effect under form of aqueous extract for the peptic ulcer cicatrization. The data of the anatomical and histological description of the stomach of mice Wistar seek to increase knowledge about this species and allowing larger access to the scientific community that he/she makes use of the species in model of peptic ulcers.