Síntese, caracterização e avaliação da atividade biológica de compostos organoestânicos

• Ano de defesa: 2003
• Autor(a) principal: Vieira, Flaviana Tavares
• Banca de defesa: Lima, Geraldo Magela de , Oliveira, Tânia Toledo de , Vilela, Marcelo José , Santos, Marcelo Henrique dos
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Viçosa
• Programa de Pós-Graduação: Mestrado em Agroquímica
• Departamento: Agroquímica analítica; Agroquímica inorgânica e Físico-química; Agroquímica orgânica
• País: BR
• Palavras-chave em Português: Compostos orgânicos de estanho; Síntese; Ensaios biológicos; Caracterização
• Palavras-chave em Inglês: Organotin compounds; Synthesis; Biological essays; Characterization
• Área do conhecimento CNPq: CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA
• Link de acesso: http://locus.ufv.br/handle/123456789/2049

This work involved the synthesis and characterization of the organotin compounds SnCl2Ph2, SnClPh3, SnCl4 SnCl4 and SnClBu3 to 7-epiclusianone (C33H42O4) and aminoguanidine bicarbonate (CH6N4.H2CO3). The new compounds were characterized by infrared spectroscopy, microanalysis, nuclear magnetic resonance of 1H, 13C and 119Sn, melting point and Mössbauer spectroscopy. The formation of complexes of ligand 7-epiclusianone (Hepi) with organotin originated the compounds Trans-[(SnCl2Ph2)2(Hepi)], Cis-[SnCl2Ph2(Hepi)], [SnClPh3(Hepi)] and [(SnCl4)2(Hepi)], in which the tin atom is hexacoordinated in solution as in the solid state. There was no reaction with SnClBu3. The overall spectroscopic data of those suggest a weak bond Sn-ethylene, except for the compound [(SnCl4)2(Hepi)]. For the complexes derivatives of the aminoguanidine bicarbonate (Hbag) with organotin originated the compounds [(SnClPh3)2(HCO3)]NH4, [(SnClPh3)3(HCO3)]NH4, [SnCl2Ph2(HCO3)]NH4.H2O and [SnCl4(Hamu)2]H2O, except the compound [(SnClPh3)2(HCO3)]NH4, in which the tin is pentacoordinated in solution as in the solid state. Tehe rest of the compounds have shown the tin atom hexacoordinated in both states. The ion HCO3- is a soft base and, this fact can justify its preferable coordination to the reagents SnClPh3 and SnCl2Ph2, which the tin is pentacoordiantion in solution as in the solid state. The rest of the compounds have shown the tin atom hexacoordianted in both states. The ion HCO3- is a soft base and, this fact can justify its preferable coordiantion to the reagents SnClPh3 and SnCl2Ph2, with have low acidity, instead of bonding a higher acid one, SnCl4. The results of biological tests for the compound [SnClPh3(Hepi)] suggest that this reduce the cellular multiplication of the cancerous cells (HN-5). However, this result does not allow to conclusions the antitumoral activity of the compound. New tests in different concentrations as well as with new type of cancerous cells are necessary to reach this goal.