Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss
Ano de defesa: | 2014 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Estadual do Oeste do Paraná
Cascavel |
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências Farmacêuticas
|
Departamento: |
Centro de Ciências Médicas e Farmacêuticas
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://tede.unioeste.br/handle/tede/3505 |
Resumo: | Ganoderma australe is a Basidiomycete species responsible for the delignification process of the organic matter known to cause "white rot" in certain species of trees. Cytochemical studies have shown that the cell wall of fungi polysaccharides has (13)- β-glucans, (16)-β-glucans type and other complex polysaccharides. Currently, it has been highlighted that the β-glucans are polysaccharides that produce higher effects as modulators of biological functions. In previous studies, the fungus G. australe has been studied regarding the composition of the cell wall polysaccharide. SK5 polysaccharide fraction was obtained after freeze-thawing of the aqueous extraction with KOH 5%. Monosaccharide composition of SK5 fraction revealed by Gas chromatography–mass spectrometry (GC-MS) showed glucose is predominant (81.3%), with presence of other sugars (mannose, arabinose, xylose, rhamnose, fucose and galactose) at concentration of less than about 3% each. The nuclear magnetic resonance of this fraction proved to be a β-glucan with glycosidic links (1→3)-β type and probably replaced in 4-O. In this study, the biological effect of SK5 polysaccharide fraction extracted from the fungus G. australe has been evaluated in vitro cell culture of peritoneal macrophages isolated from Swiss mice. The biological effect was assessed for toxicity and cell activation, nitric oxide, cytokines (TNF-α, IL-6), superoxide anion (production and scavenging capacity) and the ability to stimulate phagocytic activity. Cell viability was affected, with approximately 29% reduction with 1.0 mg / mL and 35.5% reduction with 2.5 μg/ml SK5. There was no change in nitric oxide production, TNF-α or superoxide anion concentrations between 0.1 μg/mL and 1.0 μg/mL. The scavenging ability of superoxide anion was also not detected. There was an increase in IL-6 by about 111% with 1.0 μg/mL. In regarding to phagocyte activity was increased in all concentrations examined obtaining 52.3% with 0.25 μg/mL of polysaccharide. The results indicate that (13)-β- glucan isolated from G.australe can be classified as biological response modifier (BRM). |
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Silva, José Luis da Conceiçãohttp://lattes.cnpq.br/9251091711372741Maller, Alexandrehttp://lattes.cnpq.br/8153318875076127Maller , Ana Cláudia Paiva Alegrehttp://lattes.cnpq.br/8189048974419765Melo, Eduardo Borges dehttp://lattes.cnpq.br/0732955060928431http://lattes.cnpq.br/5077247433000437Melo, Renan Henrique de2018-03-12T14:24:25Z2014-12-09MELO, Renan Henrique de. Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss. 2014. 63 f. Dissertação (Mestrado - Programa de Pós-Graduação em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel, 2014.http://tede.unioeste.br/handle/tede/3505Ganoderma australe is a Basidiomycete species responsible for the delignification process of the organic matter known to cause "white rot" in certain species of trees. Cytochemical studies have shown that the cell wall of fungi polysaccharides has (13)- β-glucans, (16)-β-glucans type and other complex polysaccharides. Currently, it has been highlighted that the β-glucans are polysaccharides that produce higher effects as modulators of biological functions. In previous studies, the fungus G. australe has been studied regarding the composition of the cell wall polysaccharide. SK5 polysaccharide fraction was obtained after freeze-thawing of the aqueous extraction with KOH 5%. Monosaccharide composition of SK5 fraction revealed by Gas chromatography–mass spectrometry (GC-MS) showed glucose is predominant (81.3%), with presence of other sugars (mannose, arabinose, xylose, rhamnose, fucose and galactose) at concentration of less than about 3% each. The nuclear magnetic resonance of this fraction proved to be a β-glucan with glycosidic links (1→3)-β type and probably replaced in 4-O. In this study, the biological effect of SK5 polysaccharide fraction extracted from the fungus G. australe has been evaluated in vitro cell culture of peritoneal macrophages isolated from Swiss mice. The biological effect was assessed for toxicity and cell activation, nitric oxide, cytokines (TNF-α, IL-6), superoxide anion (production and scavenging capacity) and the ability to stimulate phagocytic activity. Cell viability was affected, with approximately 29% reduction with 1.0 mg / mL and 35.5% reduction with 2.5 μg/ml SK5. There was no change in nitric oxide production, TNF-α or superoxide anion concentrations between 0.1 μg/mL and 1.0 μg/mL. The scavenging ability of superoxide anion was also not detected. There was an increase in IL-6 by about 111% with 1.0 μg/mL. In regarding to phagocyte activity was increased in all concentrations examined obtaining 52.3% with 0.25 μg/mL of polysaccharide. The results indicate that (13)-β- glucan isolated from G.australe can be classified as biological response modifier (BRM).Ganoderma australe é uma das espécies de basidiomicetos responsáveis pelo processo de deslignificação da matéria orgânica, conhecido por causar a “podridão branca” em algumas espécies de árvores. Estudos citoquímicos demostraram que a parede celular dos fungos possui polissacarídeos do tipo β (13)-glucanas, β (16)-glucanas e outros polissacarídeos complexos. Atualmente, tem-se destacado que as β-glucanas são os polissacarídeos que produzem efeitos mais intensos como moduladores das funções biológicas. Em estudos anteriores desenvolvidos em nosso laboratório, o fungo G. australe foi estudado quanto à composição polissacarídica da parede celular. A fração polissacarídica SK5 foi obtida após gelo-degelo da extração aquosa com KOH 5%. A composição monossacarídica da fração SK5 revelada por Cromatografia Gasosa acoplada a Espectrometria de Massa (GC-MS) mostrou que glicose é predominante (81,3%), com a presença de outros açúcares (manose, arabinose, xilose, ramnose, fucose e galactose) em concentração inferior a cerca de 3% cada um. A ressonância magnética nuclear desta fração comprovou ser uma β-glucana, com ligações glicosídicas do tipo β- 1→3 e provavelmente substituídas em 4-O. Neste trabalho, o efeito biológico da fração polissacarídica SK5 extraída do fungo G. australe foi avaliado in vitro em cultura de células de macrófagos peritoneais isoladas de camundongos Swiss. Foi analisado o efeito biológico quanto à toxicidade e ativação celular, a produção de óxido nítrico, citocinas (TNF-α, IL-6), ânion superóxido (produção e capacidade sequestradora) e a capacidade de estimular a atividade fagocítica. A viabilidade celular foi significativamente afetada, com cerca de 29% de redução com 1,0 μg/mL e 35,5% de redução com 2,5 μg/mL de SK5. Não houve alteração na produção de óxido nítrico, TNF-α ou de ânion superóxido nas concentrações entre 0,1 μg/mL e 1,0 μg/mL. A capacidade sequestradora de ânion superóxido também não foi constatada. Houve aumento na produção de IL-6 em cerca de 111% com 1,0 μg/mL. Em relação à atividade fagocítica houve aumento em todas as concentrações analisadas, chegando a 52,3% com 0,25 μg/mL do polissacarídeo. Os resultados obtidos indicam que a β (13)-glucana isolada de Ganoderma australe pode ser classificada como modificadora de resposta biológica (MRB).Submitted by Neusa Fagundes (neusa.fagundes@unioeste.br) on 2018-03-12T14:24:25Z No. of bitstreams: 2 Renan_Melo2014.pdf: 1848176 bytes, checksum: 102deb99625acf4c43610c22cb0234f3 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2018-03-12T14:24:25Z (GMT). No. of bitstreams: 2 Renan_Melo2014.pdf: 1848176 bytes, checksum: 102deb99625acf4c43610c22cb0234f3 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2014-12-09Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfpor6588633818200016417500Universidade Estadual do Oeste do ParanáCascavelPrograma de Pós-Graduação em Ciências FarmacêuticasUNIOESTEBrasilCentro de Ciências Médicas e Farmacêuticashttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessPolissacarídeoInterleucinaFagocitosePolysaccharideInterleukinPhagocytosisCIENCIAS DA SAUDE::FARMACIAAvaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swissEvaluation of biological effects of SK5 fraction polysaccharide isolated fungus Ganoderma australe in mouse swiss macrophagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis7878055067573953101600600600600-894043971338784926769976364134497549962075167498588264571reponame:Biblioteca Digital de Teses e Dissertações do UNIOESTEinstname:Universidade Estadual do Oeste do Paraná (UNIOESTE)instacron:UNIOESTEORIGINALRenan_Melo2014.pdfRenan_Melo2014.pdfapplication/pdf1848176http://tede.unioeste.br:8080/tede/bitstream/tede/3505/5/Renan_Melo2014.pdf102deb99625acf4c43610c22cb0234f3MD55CC-LICENSElicense_urllicense_urltext/plain; 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dc.title.por.fl_str_mv |
Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss |
dc.title.alternative.eng.fl_str_mv |
Evaluation of biological effects of SK5 fraction polysaccharide isolated fungus Ganoderma australe in mouse swiss macrophages |
title |
Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss |
spellingShingle |
Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss Melo, Renan Henrique de Polissacarídeo Interleucina Fagocitose Polysaccharide Interleukin Phagocytosis CIENCIAS DA SAUDE::FARMACIA |
title_short |
Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss |
title_full |
Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss |
title_fullStr |
Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss |
title_full_unstemmed |
Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss |
title_sort |
Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss |
author |
Melo, Renan Henrique de |
author_facet |
Melo, Renan Henrique de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Silva, José Luis da Conceição |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9251091711372741 |
dc.contributor.referee1.fl_str_mv |
Maller, Alexandre |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/8153318875076127 |
dc.contributor.referee2.fl_str_mv |
Maller , Ana Cláudia Paiva Alegre |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/8189048974419765 |
dc.contributor.referee3.fl_str_mv |
Melo, Eduardo Borges de |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/0732955060928431 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5077247433000437 |
dc.contributor.author.fl_str_mv |
Melo, Renan Henrique de |
contributor_str_mv |
Silva, José Luis da Conceição Maller, Alexandre Maller , Ana Cláudia Paiva Alegre Melo, Eduardo Borges de |
dc.subject.por.fl_str_mv |
Polissacarídeo Interleucina Fagocitose |
topic |
Polissacarídeo Interleucina Fagocitose Polysaccharide Interleukin Phagocytosis CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
Polysaccharide Interleukin Phagocytosis |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FARMACIA |
description |
Ganoderma australe is a Basidiomycete species responsible for the delignification process of the organic matter known to cause "white rot" in certain species of trees. Cytochemical studies have shown that the cell wall of fungi polysaccharides has (13)- β-glucans, (16)-β-glucans type and other complex polysaccharides. Currently, it has been highlighted that the β-glucans are polysaccharides that produce higher effects as modulators of biological functions. In previous studies, the fungus G. australe has been studied regarding the composition of the cell wall polysaccharide. SK5 polysaccharide fraction was obtained after freeze-thawing of the aqueous extraction with KOH 5%. Monosaccharide composition of SK5 fraction revealed by Gas chromatography–mass spectrometry (GC-MS) showed glucose is predominant (81.3%), with presence of other sugars (mannose, arabinose, xylose, rhamnose, fucose and galactose) at concentration of less than about 3% each. The nuclear magnetic resonance of this fraction proved to be a β-glucan with glycosidic links (1→3)-β type and probably replaced in 4-O. In this study, the biological effect of SK5 polysaccharide fraction extracted from the fungus G. australe has been evaluated in vitro cell culture of peritoneal macrophages isolated from Swiss mice. The biological effect was assessed for toxicity and cell activation, nitric oxide, cytokines (TNF-α, IL-6), superoxide anion (production and scavenging capacity) and the ability to stimulate phagocytic activity. Cell viability was affected, with approximately 29% reduction with 1.0 mg / mL and 35.5% reduction with 2.5 μg/ml SK5. There was no change in nitric oxide production, TNF-α or superoxide anion concentrations between 0.1 μg/mL and 1.0 μg/mL. The scavenging ability of superoxide anion was also not detected. There was an increase in IL-6 by about 111% with 1.0 μg/mL. In regarding to phagocyte activity was increased in all concentrations examined obtaining 52.3% with 0.25 μg/mL of polysaccharide. The results indicate that (13)-β- glucan isolated from G.australe can be classified as biological response modifier (BRM). |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-12-09 |
dc.date.accessioned.fl_str_mv |
2018-03-12T14:24:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MELO, Renan Henrique de. Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss. 2014. 63 f. Dissertação (Mestrado - Programa de Pós-Graduação em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel, 2014. |
dc.identifier.uri.fl_str_mv |
http://tede.unioeste.br/handle/tede/3505 |
identifier_str_mv |
MELO, Renan Henrique de. Avaliação dos efeitos biológicos da fração polissacarídica SK5 isolada do fungo Ganoderma australe em macrófagos de camundongo swiss. 2014. 63 f. Dissertação (Mestrado - Programa de Pós-Graduação em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel, 2014. |
url |
http://tede.unioeste.br/handle/tede/3505 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
7878055067573953101 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
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dc.relation.cnpq.fl_str_mv |
6997636413449754996 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual do Oeste do Paraná Cascavel |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Farmacêuticas |
dc.publisher.initials.fl_str_mv |
UNIOESTE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Centro de Ciências Médicas e Farmacêuticas |
publisher.none.fl_str_mv |
Universidade Estadual do Oeste do Paraná Cascavel |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações do UNIOESTE instname:Universidade Estadual do Oeste do Paraná (UNIOESTE) instacron:UNIOESTE |
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Universidade Estadual do Oeste do Paraná (UNIOESTE) |
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UNIOESTE |
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UNIOESTE |
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Biblioteca Digital de Teses e Dissertações do UNIOESTE |
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Biblioteca Digital de Teses e Dissertações do UNIOESTE |
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http://tede.unioeste.br:8080/tede/bitstream/tede/3505/5/Renan_Melo2014.pdf http://tede.unioeste.br:8080/tede/bitstream/tede/3505/2/license_url http://tede.unioeste.br:8080/tede/bitstream/tede/3505/3/license_text http://tede.unioeste.br:8080/tede/bitstream/tede/3505/4/license_rdf http://tede.unioeste.br:8080/tede/bitstream/tede/3505/1/license.txt |
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Biblioteca Digital de Teses e Dissertações do UNIOESTE - Universidade Estadual do Oeste do Paraná (UNIOESTE) |
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biblioteca.repositorio@unioeste.br |
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