Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato

Detalhes bibliográficos
Ano de defesa: 2017
Autor(a) principal: Ferreira, Fabiana Sari lattes
Orientador(a): Marek, Carla Brugin lattes
Banca de defesa: Marek, Carla Brugin lattes, Sagae, Sara Cristina lattes, Baroni, Silmara lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Estadual do Oeste do Paraná
Cascavel
Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências Farmacêuticas
Departamento: Centro de Ciências Médicas e Farmacêuticas
País: Brasil
Palavras-chave em Português:
Acetilcolinesterase
Agrotóxico
Flavonoides
Palavras-chave em Inglês:
Acetylcholinesterase
Pesticides
Flavonoid
Área do conhecimento CNPq:
CIENCIAS DA SAUDE::FARMACIA
Link de acesso: http://tede.unioeste.br/handle/tede/2955
Resumo: Carbamates are essential products for pesticide formulation, mainly used in agriculture for the elimination of insects. Although the production and trade of carbamates are for purpose insects elimination, it is common used to suicide attempts in our environment, in addition to accidental poisonings involving rural workers and children. The toxicological property is inhibit the acetylcholinesterase and buthyrylcholinesterase enzymes which leads a severe poisoning related to cholinergic crisis. The enzymes activity get back to normal only spontaneously, so the study of new substances that can intervene directly on the active site of these enzymes when it is inhibited and reverse this toxic action is necessity for the health. Researchs with Melia azedarach L. (Meliaceae) has been made searching for new strategies for treatment of enzime inhibity by methyl carbamate poisoning. Different concentrations of Melia azedarach L. buffered extract were tested in vitro and in vivo for acetylcholinesterase activity inhibited by methylcarbamate. The results showed that the extract of Melia azedarach L. has a potential reversion effect on the enzyme inhibited by methyl carbamate, becoming an alternative to treatment of carbamate intoxication
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spelling Marek, Carla Bruginhttp://lattes.cnpq.br/2802989594048763Marek, Carla Bruginhttp://lattes.cnpq.br/2802989594048763Sagae, Sara Cristinahttp://lattes.cnpq.br/4952215583363653Baroni, Silmarahttp://lattes.cnpq.br/5828140324071034http://lattes.cnpq.br/1965756156558838Ferreira, Fabiana Sari2017-08-29T18:48:40Z2017-02-06FERREIRA, Fabiana Sari. Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato. 2017. 96 f. Dissertação ( Mestrado em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel, 2017.http://tede.unioeste.br/handle/tede/2955Carbamates are essential products for pesticide formulation, mainly used in agriculture for the elimination of insects. Although the production and trade of carbamates are for purpose insects elimination, it is common used to suicide attempts in our environment, in addition to accidental poisonings involving rural workers and children. The toxicological property is inhibit the acetylcholinesterase and buthyrylcholinesterase enzymes which leads a severe poisoning related to cholinergic crisis. The enzymes activity get back to normal only spontaneously, so the study of new substances that can intervene directly on the active site of these enzymes when it is inhibited and reverse this toxic action is necessity for the health. Researchs with Melia azedarach L. (Meliaceae) has been made searching for new strategies for treatment of enzime inhibity by methyl carbamate poisoning. Different concentrations of Melia azedarach L. buffered extract were tested in vitro and in vivo for acetylcholinesterase activity inhibited by methylcarbamate. The results showed that the extract of Melia azedarach L. has a potential reversion effect on the enzyme inhibited by methyl carbamate, becoming an alternative to treatment of carbamate intoxicationOs carbamatos são produtos fundamentais para a formulação de praguicidas. Embora sua produção e a comercialização sejam com a finalidade de eliminação de insetos, a sua utilização em tentativas de suicídio é comum em nosso meio, além das intoxicações acidentais envolvendo trabalhadores rurais e crianças, devido sua propriedade toxicológica em inibir as enzimas acetilcolinesterase e butirilcolinesterase. A atividade destas enzimas só volta ao normal espontaneamente, assim, o objetivo deste trabalho foi verificar a possível ação do extrato de folhas de Melia azedarach L. sobre o sistema colinérgico inibido por metilcarbamato. Foram testadas in vitro e in vivo, diferentes concentrações de extrato tamponado de Melia azedarach L., quanto a atividade da acetilcolinesterase inibida por metilcarbamato. Os resultados mostraram que o extrato de Melia azedarach L. tem potencial efeito de reversão sobre a enzima inibida pelo metilcarbamato, se tornando uma alternativa na terapia do tratamento de intoxicações com carbamatos.Submitted by Rosangela Silva (rosangela.silva3@unioeste.br) on 2017-08-29T18:48:40Z No. of bitstreams: 2 DISSERTAÇÃO VERSÃO FINAL - FABIANA SARI FERREIRA.pdf: 3287035 bytes, checksum: 4366071c4629680884533f5c945e6d0e (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2017-08-29T18:48:40Z (GMT). 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dc.title.por.fl_str_mv Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato
dc.title.alternative.eng.fl_str_mv The effect of extract of Melia azedarach L. on cholinergic system of rats poisoned with methyl carbamate
title Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato
spellingShingle Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato
Ferreira, Fabiana Sari
Acetilcolinesterase
Agrotóxico
Flavonoides
Acetylcholinesterase
Pesticides
Flavonoid
CIENCIAS DA SAUDE::FARMACIA
title_short Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato
title_full Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato
title_fullStr Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato
title_full_unstemmed Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato
title_sort Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato
author Ferreira, Fabiana Sari
author_facet Ferreira, Fabiana Sari
author_role author
dc.contributor.advisor1.fl_str_mv Marek, Carla Brugin
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/2802989594048763
dc.contributor.referee1.fl_str_mv Marek, Carla Brugin
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/2802989594048763
dc.contributor.referee2.fl_str_mv Sagae, Sara Cristina
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/4952215583363653
dc.contributor.referee3.fl_str_mv Baroni, Silmara
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/5828140324071034
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1965756156558838
dc.contributor.author.fl_str_mv Ferreira, Fabiana Sari
contributor_str_mv Marek, Carla Brugin
Marek, Carla Brugin
Sagae, Sara Cristina
Baroni, Silmara
dc.subject.por.fl_str_mv Acetilcolinesterase
Agrotóxico
Flavonoides
topic Acetilcolinesterase
Agrotóxico
Flavonoides
Acetylcholinesterase
Pesticides
Flavonoid
CIENCIAS DA SAUDE::FARMACIA
dc.subject.eng.fl_str_mv Acetylcholinesterase
Pesticides
Flavonoid
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::FARMACIA
description Carbamates are essential products for pesticide formulation, mainly used in agriculture for the elimination of insects. Although the production and trade of carbamates are for purpose insects elimination, it is common used to suicide attempts in our environment, in addition to accidental poisonings involving rural workers and children. The toxicological property is inhibit the acetylcholinesterase and buthyrylcholinesterase enzymes which leads a severe poisoning related to cholinergic crisis. The enzymes activity get back to normal only spontaneously, so the study of new substances that can intervene directly on the active site of these enzymes when it is inhibited and reverse this toxic action is necessity for the health. Researchs with Melia azedarach L. (Meliaceae) has been made searching for new strategies for treatment of enzime inhibity by methyl carbamate poisoning. Different concentrations of Melia azedarach L. buffered extract were tested in vitro and in vivo for acetylcholinesterase activity inhibited by methylcarbamate. The results showed that the extract of Melia azedarach L. has a potential reversion effect on the enzyme inhibited by methyl carbamate, becoming an alternative to treatment of carbamate intoxication
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-08-29T18:48:40Z
dc.date.issued.fl_str_mv 2017-02-06
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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dc.identifier.citation.fl_str_mv FERREIRA, Fabiana Sari. Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato. 2017. 96 f. Dissertação ( Mestrado em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel, 2017.
dc.identifier.uri.fl_str_mv http://tede.unioeste.br/handle/tede/2955
identifier_str_mv FERREIRA, Fabiana Sari. Efeito do extrato de Melia azedarach L. sobre o sistema colinérgico em ratos intoxicados com metilcarbamato. 2017. 96 f. Dissertação ( Mestrado em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel, 2017.
url http://tede.unioeste.br/handle/tede/2955
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dc.publisher.none.fl_str_mv Universidade Estadual do Oeste do Paraná
Cascavel
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Ciências Farmacêuticas
dc.publisher.initials.fl_str_mv UNIOESTE
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dc.publisher.department.fl_str_mv Centro de Ciências Médicas e Farmacêuticas
publisher.none.fl_str_mv Universidade Estadual do Oeste do Paraná
Cascavel
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