Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D)
Ano de defesa: | 2019 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade do Oeste Paulista
|
Programa de Pós-Graduação: |
Mestrado em Ciências da Saúde
|
Departamento: |
Mestrado em Ciências da Saúde
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://bdtd.unoeste.br:8080/jspui/handle/jspui/1213 |
Resumo: | One of the most used means for the application of pesticides is aerial spraying, despite the already known risks that this technique can bring, mainly due to the existence of technical drift. Agricultural pesticides can cause acute, subacute and chronic intoxications. The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is one of the first herbicides formulated and one of the most used to date, in the control of several weed plants, in cereal plantations, sugarcane plantations, forest control and orchards. The objective of the study was to evaluate nasopharyngeal epithelium and the hematological profile of rats submitted to chronic spraying of 2,4-D herbicide. Fourty male Wistar rats were divided into four groups: Control Group (GC), Low Concentration Group (GBC), Medium Concentration Group (GMC) and High Concentration Group (GAC). The animals were exposed from Monday to Friday, through 2 boxes attached to nebulizers, one box for the control group and the other for groups exposed to 2,4-D, which were responsible for spraying the different concentrations of herbicide for a period of 15 minutes daily for 6 consecutive months. After the exposure period, the blood sample was collected for the hemogram and the nasal epithelium was collected and analyzed by quantification of the mast cells and inflammatory infiltrate. It was observed that there was a statistically significant difference only in the haematological parameter Average Corpuscular Hemoglobin Concentration (CHCM) of the GBC when compared to the GC, but the GBC was with CHCM values within the reference values and the GC was high. Regarding the other hematological parameters, quantification of the mast cells and the inflammatory infiltrate, there was no statistically significant difference of any group exposed to the 2,4-D herbicide compared to the CG. Therefore, 2,4-D herbicide did not demonstrate toxicity to the haematological parameters and nasal epithelium of Wistar rats after chronic inhalation exposure in the 6-month period, compared to the control group, in agreement with the toxicological classification of the herbicide published Agency of Environmental Protection of the United States (EPA). It should be noted that the toxic effects need to be evaluated with research in longer periods of time than the present study. |
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Rossi, Renata Calciolarihttp://lattes.cnpq.br/9313445810035844Pereira, Danillo Roberto0122307432250869http://lattes.cnpq.br/0122307432250869Rodrigues, Marcus Vinicius Pimentahttp://lattes.cnpq.br/0133739307461180Padulla, Susimary Aparecida Trevizanhttp://lattes.cnpq.br/23931047490783114734846227548028http://lattes.cnpq.br/4734846227548028CAVALLIERI, Gabriela Vidotto2020-01-13T14:28:40Z2019-02-22CAVALLIERI, Gabriela Vidotto. Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D). 2019. Dissertação (Mestrado em Ciências da Saúde) - Universidade do Oeste Paulista, Presidente Prudente, SP, 2019.http://bdtd.unoeste.br:8080/jspui/handle/jspui/1213One of the most used means for the application of pesticides is aerial spraying, despite the already known risks that this technique can bring, mainly due to the existence of technical drift. Agricultural pesticides can cause acute, subacute and chronic intoxications. The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is one of the first herbicides formulated and one of the most used to date, in the control of several weed plants, in cereal plantations, sugarcane plantations, forest control and orchards. The objective of the study was to evaluate nasopharyngeal epithelium and the hematological profile of rats submitted to chronic spraying of 2,4-D herbicide. Fourty male Wistar rats were divided into four groups: Control Group (GC), Low Concentration Group (GBC), Medium Concentration Group (GMC) and High Concentration Group (GAC). The animals were exposed from Monday to Friday, through 2 boxes attached to nebulizers, one box for the control group and the other for groups exposed to 2,4-D, which were responsible for spraying the different concentrations of herbicide for a period of 15 minutes daily for 6 consecutive months. After the exposure period, the blood sample was collected for the hemogram and the nasal epithelium was collected and analyzed by quantification of the mast cells and inflammatory infiltrate. It was observed that there was a statistically significant difference only in the haematological parameter Average Corpuscular Hemoglobin Concentration (CHCM) of the GBC when compared to the GC, but the GBC was with CHCM values within the reference values and the GC was high. Regarding the other hematological parameters, quantification of the mast cells and the inflammatory infiltrate, there was no statistically significant difference of any group exposed to the 2,4-D herbicide compared to the CG. Therefore, 2,4-D herbicide did not demonstrate toxicity to the haematological parameters and nasal epithelium of Wistar rats after chronic inhalation exposure in the 6-month period, compared to the control group, in agreement with the toxicological classification of the herbicide published Agency of Environmental Protection of the United States (EPA). It should be noted that the toxic effects need to be evaluated with research in longer periods of time than the present study.Um dos meios mais utilizados para a aplicação dos defensivos agrícolas é a pulverização aérea, apesar dos riscos já conhecidos que essa técnica pode trazer, sobretudo devido à existência da deriva técnica. Os defensivos agrícolas podem causar intoxicações agudas, subagudas e crônicas. O herbicida Ácido 2,4-diclorofenoxiacético (2,4-D), é um dos primeiros herbicidas formulados e um dos mais utilizados até hoje, no controle de várias plantas infestantes, em plantações de cereais, cana-de-açúcar, controle florestal e pomares. O objetivo do estudo foi avaliar histopatologicamente o epitélio nasal e o perfil hematológico de ratos submetidos à pulverização crônica do herbicida 2,4-D. Foram utilizados 40 ratos Wistar adultos machos, divididos em 4 grupos, sendo eles: Grupo Controle (GC), Grupo Baixa Concentração (GBC), Grupo Média Concentração (GMC) e Grupo Alta concentração (GAC). A exposição dos animais foi realizada de segunda a sexta, por meio de 2 caixas acopladas a nebulizadores, sendo uma caixa destinada ao grupo controle e a outra aos grupos expostos ao 2,4-D, os quais eram responsáveis por pulverizar as diferentes concentrações do herbicida por um tempo de 15 minutos diários, durante 6 meses consecutivos. Após o período de exposição, foi feita a coleta de amostra de sangue para confecção do hemograma e coleta e análise do epitélio nasal por meio da quantificação dos mastócitos e infiltrado inflamatório. Foi observado que houve diferença estatisticamente significativa apenas no parâmetro hematológico Concentração de Hemoglobina Corpuscular Média (CHCM) do GBC quando comparado ao GC, porém o GBC estava com valores de CHCM dentro dos valores de referência e o GC estava elevado. Em relação aos outros parâmetros hematológicos, a quantificação dos mastócitos e do infiltrado inflamatório, não houve diferença estatisticamente significativa de nenhum grupo exposto ao herbicida 2,4-D comparados ao GC. Sendo assim, o herbicida 2,4-D não demonstrou toxicidade aos parâmetros hematológicos e epitélio nasal de ratos Wistar após exposição crônica inalatória no período de 6 meses, comparados ao grupo controle, em concordância com a classificação toxicológica do herbicida publicada Agencia de Proteção Ambiental dos Estados Unidos (EPA). Cabe ressaltar que os efeitos tóxicos precisam ser avaliados com pesquisas em períodos de tempo maiores ao realizado pelo presente trabalho.Submitted by Jakeline Ortega (jakortega@unoeste.br) on 2020-01-13T14:28:40Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Gabriela Vidotto Cavallieri.pdf: 1241404 bytes, checksum: 800c2de0fdf9c5641ae7b2fc7fe0fbdf (MD5)Made available in DSpace on 2020-01-13T14:28:40Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Gabriela Vidotto Cavallieri.pdf: 1241404 bytes, checksum: 800c2de0fdf9c5641ae7b2fc7fe0fbdf (MD5) Previous issue date: 2019-02-22Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfhttp://bdtd.unoeste.br:8080/jspui/retrieve/3456/Gabriela%20Vidotto%20Cavallieri.pdf.jpgporUniversidade do Oeste PaulistaMestrado em Ciências da SaúdeUNOESTEBrasilMestrado em Ciências da Saúdehttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessToxicidadeContagem de Células SanguíneasMucosa NasalRatosToxicityBlood Cell CountNasal MucosaRatsCIENCIAS DA SAUDEAnálise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D)Histopathological analysis in rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis4548474062520074168500500600600454847406252007416887654494148233069292075167498588264571reponame:Biblioteca Digital de Teses e Dissertações da UNOESTEinstname:Universidade do Oeste Paulista (UNOESTE)instacron:UNOESTETHUMBNAILGabriela Vidotto Cavallieri.pdf.jpgGabriela Vidotto Cavallieri.pdf.jpgimage/jpeg3694http://bdtd.unoeste.br:8080/tede/bitstream/jspui/1213/6/Gabriela+Vidotto+Cavallieri.pdf.jpg6061f26259fcd217f6a5a474aa998780MD56ORIGINALGabriela Vidotto Cavallieri.pdfGabriela Vidotto Cavallieri.pdfapplication/pdf1241404http://bdtd.unoeste.br:8080/tede/bitstream/jspui/1213/5/Gabriela+Vidotto+Cavallieri.pdf800c2de0fdf9c5641ae7b2fc7fe0fbdfMD55CC-LICENSElicense_urllicense_urltext/plain; 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dc.title.por.fl_str_mv |
Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D) |
dc.title.alternative.eng.fl_str_mv |
Histopathological analysis in rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) |
title |
Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D) |
spellingShingle |
Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D) CAVALLIERI, Gabriela Vidotto Toxicidade Contagem de Células Sanguíneas Mucosa Nasal Ratos Toxicity Blood Cell Count Nasal Mucosa Rats CIENCIAS DA SAUDE |
title_short |
Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D) |
title_full |
Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D) |
title_fullStr |
Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D) |
title_full_unstemmed |
Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D) |
title_sort |
Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D) |
author |
CAVALLIERI, Gabriela Vidotto |
author_facet |
CAVALLIERI, Gabriela Vidotto |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Rossi, Renata Calciolari |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9313445810035844 |
dc.contributor.advisor-co1.fl_str_mv |
Pereira, Danillo Roberto |
dc.contributor.advisor-co1ID.fl_str_mv |
0122307432250869 |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/0122307432250869 |
dc.contributor.referee1.fl_str_mv |
Rodrigues, Marcus Vinicius Pimenta |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/0133739307461180 |
dc.contributor.referee2.fl_str_mv |
Padulla, Susimary Aparecida Trevizan |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/2393104749078311 |
dc.contributor.authorID.fl_str_mv |
4734846227548028 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4734846227548028 |
dc.contributor.author.fl_str_mv |
CAVALLIERI, Gabriela Vidotto |
contributor_str_mv |
Rossi, Renata Calciolari Pereira, Danillo Roberto Rodrigues, Marcus Vinicius Pimenta Padulla, Susimary Aparecida Trevizan |
dc.subject.por.fl_str_mv |
Toxicidade Contagem de Células Sanguíneas Mucosa Nasal Ratos |
topic |
Toxicidade Contagem de Células Sanguíneas Mucosa Nasal Ratos Toxicity Blood Cell Count Nasal Mucosa Rats CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Toxicity Blood Cell Count Nasal Mucosa Rats |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
One of the most used means for the application of pesticides is aerial spraying, despite the already known risks that this technique can bring, mainly due to the existence of technical drift. Agricultural pesticides can cause acute, subacute and chronic intoxications. The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is one of the first herbicides formulated and one of the most used to date, in the control of several weed plants, in cereal plantations, sugarcane plantations, forest control and orchards. The objective of the study was to evaluate nasopharyngeal epithelium and the hematological profile of rats submitted to chronic spraying of 2,4-D herbicide. Fourty male Wistar rats were divided into four groups: Control Group (GC), Low Concentration Group (GBC), Medium Concentration Group (GMC) and High Concentration Group (GAC). The animals were exposed from Monday to Friday, through 2 boxes attached to nebulizers, one box for the control group and the other for groups exposed to 2,4-D, which were responsible for spraying the different concentrations of herbicide for a period of 15 minutes daily for 6 consecutive months. After the exposure period, the blood sample was collected for the hemogram and the nasal epithelium was collected and analyzed by quantification of the mast cells and inflammatory infiltrate. It was observed that there was a statistically significant difference only in the haematological parameter Average Corpuscular Hemoglobin Concentration (CHCM) of the GBC when compared to the GC, but the GBC was with CHCM values within the reference values and the GC was high. Regarding the other hematological parameters, quantification of the mast cells and the inflammatory infiltrate, there was no statistically significant difference of any group exposed to the 2,4-D herbicide compared to the CG. Therefore, 2,4-D herbicide did not demonstrate toxicity to the haematological parameters and nasal epithelium of Wistar rats after chronic inhalation exposure in the 6-month period, compared to the control group, in agreement with the toxicological classification of the herbicide published Agency of Environmental Protection of the United States (EPA). It should be noted that the toxic effects need to be evaluated with research in longer periods of time than the present study. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-02-22 |
dc.date.accessioned.fl_str_mv |
2020-01-13T14:28:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CAVALLIERI, Gabriela Vidotto. Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D). 2019. Dissertação (Mestrado em Ciências da Saúde) - Universidade do Oeste Paulista, Presidente Prudente, SP, 2019. |
dc.identifier.uri.fl_str_mv |
http://bdtd.unoeste.br:8080/jspui/handle/jspui/1213 |
identifier_str_mv |
CAVALLIERI, Gabriela Vidotto. Análise histopatológica em ratos expostos cronicamente por via inalatória ao herbicida Ácido 2,4-Diclorofenoxiacético (2,4-D). 2019. Dissertação (Mestrado em Ciências da Saúde) - Universidade do Oeste Paulista, Presidente Prudente, SP, 2019. |
url |
http://bdtd.unoeste.br:8080/jspui/handle/jspui/1213 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
4548474062520074168 |
dc.relation.confidence.fl_str_mv |
500 500 600 600 |
dc.relation.department.fl_str_mv |
4548474062520074168 |
dc.relation.cnpq.fl_str_mv |
8765449414823306929 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade do Oeste Paulista |
dc.publisher.program.fl_str_mv |
Mestrado em Ciências da Saúde |
dc.publisher.initials.fl_str_mv |
UNOESTE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Mestrado em Ciências da Saúde |
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Universidade do Oeste Paulista |
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Biblioteca Digital de Teses e Dissertações da UNOESTE - Universidade do Oeste Paulista (UNOESTE) |
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