Estudo Laboratorial do Uso da Cefovecina em Cães Sadios

Detalhes bibliográficos
Ano de defesa: 2012
Autor(a) principal: Silva, Dheywid Karlos Mattos lattes
Orientador(a): Laposy, Cecília Braga
Banca de defesa: Nogueira, Rosa Maria Barilli lattes, Flaiban, Karina Keller Marques da Costa lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade do Oeste Paulista
Programa de Pós-Graduação: Mestrado em Ciência Animal
Departamento: Ciências Agrárias
País: BR
Palavras-chave em Português:
Cães
Cefovecina
Função renal
Hematologia
Plaquetas
Palavras-chave em Inglês:
Dogs
Cefovecin
Renal function
Hematology
Platelet
Área do conhecimento CNPq:
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
Link de acesso: http://bdtd.unoeste.br:8080/tede/handle/tede/262
Resumo: Cefovecin is the newest semisynthetic cephalosporin. The drug is indicated for treatment of skin and urinary infections. The aim of this study was to evaluate the influence of cefovecin therapy on the hemogram, platelet distribution width (PDW) and platelet count, blood gas, serum proteins, and on the activity of urea and creatinine. Ten healthy dogs (males n=4; females n=6), average weight of 10.03±3.54 kg were used. The animals were kept in individual cages all over the experiment. The dogs were nourished with a commercial feed ad libitum drinking. The animals were submitted to the clinical and laboratory examinations as an inclusion criterion for the experiment. Sodium cefovecin (Convenia®) was subcutaneously administered (8mg/kg) to the dogs. Clinical evaluation and laboratorial analysis was performed prior and at 1, 2, 3, 7, 14 and 21 days post treatment (dpt). Despite to be in accordance with the reference values, a statistically significant (p<0.05) decrease in total serum protein, globulin, hemoglobin and packed cell volume was observed at the 21 dpt. The platelet distribution width (PDW) and platelet count were increased at seven and 21 days (p>0.05), respectively. No changes in urea and creatinine activities, blood gas and leukocyte values were observed in the dogs after the administration of cefovecin. In conclusion, cefovecin can be administered in healthy dogs without causing significant laboratory abnormalities
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spelling Laposy, Cecília BragaCPF:11651891869Nogueira, Rosa Maria BarilliCPF:06991647888http://lattes.cnpq.br/7556647746768615Flaiban, Karina Keller Marques da CostaCPF:03962160984http://lattes.cnpq.br/2471345586742110CPF:00875055176http://lattes.cnpq.br/7656867029148906Silva, Dheywid Karlos Mattos2016-01-26T18:55:34Z2012-12-132012-10-01SILVA, Dheywid Karlos Mattos. Laboratory Evaluation of the Use of Cefovecin in Healthy Dogs. 2012. 28 f. Dissertação (Mestrado em Ciências Agrárias) - Universidade do Oeste Paulista, Presidente Prudente, 2012.http://bdtd.unoeste.br:8080/tede/handle/tede/262Cefovecin is the newest semisynthetic cephalosporin. The drug is indicated for treatment of skin and urinary infections. The aim of this study was to evaluate the influence of cefovecin therapy on the hemogram, platelet distribution width (PDW) and platelet count, blood gas, serum proteins, and on the activity of urea and creatinine. Ten healthy dogs (males n=4; females n=6), average weight of 10.03±3.54 kg were used. The animals were kept in individual cages all over the experiment. The dogs were nourished with a commercial feed ad libitum drinking. The animals were submitted to the clinical and laboratory examinations as an inclusion criterion for the experiment. Sodium cefovecin (Convenia®) was subcutaneously administered (8mg/kg) to the dogs. Clinical evaluation and laboratorial analysis was performed prior and at 1, 2, 3, 7, 14 and 21 days post treatment (dpt). Despite to be in accordance with the reference values, a statistically significant (p<0.05) decrease in total serum protein, globulin, hemoglobin and packed cell volume was observed at the 21 dpt. The platelet distribution width (PDW) and platelet count were increased at seven and 21 days (p>0.05), respectively. No changes in urea and creatinine activities, blood gas and leukocyte values were observed in the dogs after the administration of cefovecin. In conclusion, cefovecin can be administered in healthy dogs without causing significant laboratory abnormalitiesA cefovecina é a mais nova droga semissintética cefalosporina. O fármaco é indicado para tratamento de infecções de pele e do trato urinário. O objetivo do estudo foi avaliar a influência da terapia com cefovecina sobre os valores do hemograma, distribuição do diâmetro das plaquetas (PDW), contagem plaquetária, hemogasometria, proteínas séricas e sobre a atividade de uréia e creatinina. Foram usados dez cães hígidos (machos n=4; fêmeas n=6), com peso médio de 10,03±3,54 Kg. Os animais permaneceram durante todo o experimento em baias individuais, recebendo ração comercial duas vezes ao dia e água a vontade. Como critérios de inclusão dos animais para o experimento, foram realizados exames clínicos e laboratoriais. Os cães receberam cefovecina sódica (Convenia®) subcutânea, na dose de 8mg/Kg e foram acompanhados clínica e laboratorialmente com 1, 2, 3, 7, 14 e 21 dias pós tratamento (dpt). Apesar dos valores permanecerem dentro da faixa de normalidade para a espécie, houve uma diminuição significativa (P<0,05) nos valores da proteína sérica, globulinas, hemoglobina e volume globular aos 21(dpt). O diâmetro das plaquetas (PDW), bem como sua contagem diminuíram aos 7 e 21 dias (P>0,05), respectivamente. Não houve alterações nas atividades de uréia e creatinina, hemogasometria e valores leucocitários após a administração da cefovecina. Conclui-se que a cefovecina pode ser administrada em cães saudáveis sem causa anormalidades laboratoriais significantes.Made available in DSpace on 2016-01-26T18:55:34Z (GMT). No. of bitstreams: 1 Dheywid.pdf: 151244 bytes, checksum: 67957de7a93f293ea07766dba8d943a1 (MD5) Previous issue date: 2012-10-01application/pdfhttp://bdtd.unoeste.br:8080/tede/retrieve/750/Dheywid.pdf.jpgporUniversidade do Oeste PaulistaMestrado em Ciência AnimalUNOESTEBRCiências AgráriasCãesCefovecinaFunção renalHematologiaPlaquetasDogsCefovecinRenal functionHematologyPlateletCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIAEstudo Laboratorial do Uso da Cefovecina em Cães SadiosLaboratory Evaluation of the Use of Cefovecin in Healthy Dogsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis1886725639743614135500info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UNOESTEinstname:Universidade do Oeste Paulista (UNOESTE)instacron:UNOESTEORIGINALDheywid.pdfapplication/pdf151244http://bdtd.unoeste.br:8080/tede/bitstream/tede/262/1/Dheywid.pdf67957de7a93f293ea07766dba8d943a1MD51THUMBNAILDheywid.pdf.jpgDheywid.pdf.jpgimage/jpeg2159http://bdtd.unoeste.br:8080/tede/bitstream/tede/262/2/Dheywid.pdf.jpg664df4e557256d151529f6bf0f6eebf8MD52tede/2622016-01-27 01:03:19.146oai:bdtd.unoeste.br:tede/262Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.unoeste.br:8080/jspui/PUBhttp://bdtd.unoeste.br:8080/oai/requestbdtd@unoeste.bropendoar:2016-01-27T03:03:19Biblioteca Digital de Teses e Dissertações da UNOESTE - Universidade do Oeste Paulista (UNOESTE)false
dc.title.por.fl_str_mv Estudo Laboratorial do Uso da Cefovecina em Cães Sadios
dc.title.alternative.eng.fl_str_mv Laboratory Evaluation of the Use of Cefovecin in Healthy Dogs
title Estudo Laboratorial do Uso da Cefovecina em Cães Sadios
spellingShingle Estudo Laboratorial do Uso da Cefovecina em Cães Sadios
Silva, Dheywid Karlos Mattos
Cães
Cefovecina
Função renal
Hematologia
Plaquetas
Dogs
Cefovecin
Renal function
Hematology
Platelet
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
title_short Estudo Laboratorial do Uso da Cefovecina em Cães Sadios
title_full Estudo Laboratorial do Uso da Cefovecina em Cães Sadios
title_fullStr Estudo Laboratorial do Uso da Cefovecina em Cães Sadios
title_full_unstemmed Estudo Laboratorial do Uso da Cefovecina em Cães Sadios
title_sort Estudo Laboratorial do Uso da Cefovecina em Cães Sadios
author Silva, Dheywid Karlos Mattos
author_facet Silva, Dheywid Karlos Mattos
author_role author
dc.contributor.advisor1.fl_str_mv Laposy, Cecília Braga
dc.contributor.advisor1ID.fl_str_mv CPF:11651891869
dc.contributor.referee1.fl_str_mv Nogueira, Rosa Maria Barilli
dc.contributor.referee1ID.fl_str_mv CPF:06991647888
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/7556647746768615
dc.contributor.referee2.fl_str_mv Flaiban, Karina Keller Marques da Costa
dc.contributor.referee2ID.fl_str_mv CPF:03962160984
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/2471345586742110
dc.contributor.authorID.fl_str_mv CPF:00875055176
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/7656867029148906
dc.contributor.author.fl_str_mv Silva, Dheywid Karlos Mattos
contributor_str_mv Laposy, Cecília Braga
Nogueira, Rosa Maria Barilli
Flaiban, Karina Keller Marques da Costa
dc.subject.por.fl_str_mv Cães
Cefovecina
Função renal
Hematologia
Plaquetas
topic Cães
Cefovecina
Função renal
Hematologia
Plaquetas
Dogs
Cefovecin
Renal function
Hematology
Platelet
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
dc.subject.eng.fl_str_mv Dogs
Cefovecin
Renal function
Hematology
Platelet
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
description Cefovecin is the newest semisynthetic cephalosporin. The drug is indicated for treatment of skin and urinary infections. The aim of this study was to evaluate the influence of cefovecin therapy on the hemogram, platelet distribution width (PDW) and platelet count, blood gas, serum proteins, and on the activity of urea and creatinine. Ten healthy dogs (males n=4; females n=6), average weight of 10.03±3.54 kg were used. The animals were kept in individual cages all over the experiment. The dogs were nourished with a commercial feed ad libitum drinking. The animals were submitted to the clinical and laboratory examinations as an inclusion criterion for the experiment. Sodium cefovecin (Convenia®) was subcutaneously administered (8mg/kg) to the dogs. Clinical evaluation and laboratorial analysis was performed prior and at 1, 2, 3, 7, 14 and 21 days post treatment (dpt). Despite to be in accordance with the reference values, a statistically significant (p<0.05) decrease in total serum protein, globulin, hemoglobin and packed cell volume was observed at the 21 dpt. The platelet distribution width (PDW) and platelet count were increased at seven and 21 days (p>0.05), respectively. No changes in urea and creatinine activities, blood gas and leukocyte values were observed in the dogs after the administration of cefovecin. In conclusion, cefovecin can be administered in healthy dogs without causing significant laboratory abnormalities
publishDate 2012
dc.date.available.fl_str_mv 2012-12-13
dc.date.issued.fl_str_mv 2012-10-01
dc.date.accessioned.fl_str_mv 2016-01-26T18:55:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Dheywid Karlos Mattos. Laboratory Evaluation of the Use of Cefovecin in Healthy Dogs. 2012. 28 f. Dissertação (Mestrado em Ciências Agrárias) - Universidade do Oeste Paulista, Presidente Prudente, 2012.
dc.identifier.uri.fl_str_mv http://bdtd.unoeste.br:8080/tede/handle/tede/262
identifier_str_mv SILVA, Dheywid Karlos Mattos. Laboratory Evaluation of the Use of Cefovecin in Healthy Dogs. 2012. 28 f. Dissertação (Mestrado em Ciências Agrárias) - Universidade do Oeste Paulista, Presidente Prudente, 2012.
url http://bdtd.unoeste.br:8080/tede/handle/tede/262
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language por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Universidade do Oeste Paulista
dc.publisher.program.fl_str_mv Mestrado em Ciência Animal
dc.publisher.initials.fl_str_mv UNOESTE
dc.publisher.country.fl_str_mv BR
dc.publisher.department.fl_str_mv Ciências Agrárias
publisher.none.fl_str_mv Universidade do Oeste Paulista
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UNOESTE
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