Comparação do uso do Tacrolimus 0,03% colírio dissolvido em óleo de amêndoa e de semente de linhaça no tratamento de ceratoconjuntivite seca experimental em coelhos

• Ano de defesa: 2011
• Autor(a) principal: Sgrignoli, Marcos Rogerio
• Orientador(a): Andrade, Silvia Maria Caldeira Franco
• Banca de defesa: Nogueira, Rosa Maria Barilli , Bolzan, Aline Adriana
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Oeste Paulista
• Programa de Pós-Graduação: Mestrado em Ciência Animal
• Departamento: Ciências Agrárias
• País: BR
• Palavras-chave em Português: Ceratoconjuntivite seca; citologia esfoliativa da superfície ocular; coelhos, óleo de amêndoa; óleo de semente de linhaça; histopatológico, tacrolimus.
• Palavras-chave em Inglês: Keratoconjunctivitis sicca; cytology of the ocular superface; rabbits, amond oil; seed linseed oil; histopathological; tacrolimus
• Área do conhecimento CNPq: CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
• Link de acesso: http://bdtd.unoeste.br:8080/tede/handle/tede/250

Keratoconjunctivitis sicca is an ophthalmic disorder that affects the tear. The objective of this study was to evaluate the efficacy of tacrolimus dissolved in almond oil (OA) and linseed (OSL) in the treatment of dry eye syndrome (CCS) induced in rabbits. This study used twenty-five white male rabbits of New Zealand race. The animals were divided into five groups, Group C (control), Group TA (tacrolimus OA), Group TL (OSL tacrolimus), Group A (OA) and Group L (OSL), and were evaluated weekly by Tear Test Schirmer (TLS), Fluorescein Test (TF) and Rose Bengal Test (TRB), monthly by the exfoliative cytology of the ocular surface (CESO), and histopathology at the end of the experiment. The values were significant in TLS with an increase in all treated groups after induction of CCS, featuring improved performance, the group L. In TF, was earlier resolution of corneal ulcers with groups A and L, while in the performance of TRB groups was similar. The TA and TL groups showed less edema and degeneration of the cornea and conjunctiva. Significant increase in the number of goblet cells in all treated groups, especially in groups TA and TL. The evaluation results show that tacrolimus not only with its immunosuppressive effect, but also oily vehicles used for dilution, possibly due to their anti-inflammatory properties, were responsible in improving symptoms of dry eye induced in rabbits