Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva
Ano de defesa: | 2019 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade do Oeste Paulista
|
Programa de Pós-Graduação: |
Mestrado em Ciências da Saúde
|
Departamento: |
Mestrado em Ciências da Saúde
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://bdtd.unoeste.br:8080/jspui/handle/jspui/1217 |
Resumo: | History: The gestation at the extremes of reproductive ages is characterized as High Risk.The colostrum is the first milk secretion produced and contains the necessary nutrients for the development of the newborn. The objectives were to compare the concentration of IL-1β, IL-6, IL-8, and TNF-α cytokines of adolescent and advanced maternal age mothers colostrum, and to describe demographic, gestational and perinatal socioeconomic characteristics. Methods and results: A cross-sectional study, which included 117 adolescent nursing mothers (up to 24 years of age), 158 nursing mothers of the control group (25 to 34 years), and 39 nursing mothers with advanced maternal age (over 35 years of age) attending the Maternity Hospital of Presidente Prudente. The colostrum samples were obtained by manual milking between 48 and 72 hours post childbirth. The cytokine determination was performed by immunoenzymatic assay (ELISA). The socio-demographic and gestational variables were analyzed by the X² test and the cytokines by the Kruskal-Wallis test, followed by the Dunn test, and the significance level was 5%. The median age in nursing mothers with advanced maternal age was 37 years, statistically superior to the 20-year-old female adolescents. The stable union prevailed among the groups and 81.2% of the adolescent nursing mothers did not exercise gainful activity. In 69.2% of the nursing mothers with advanced maternal age the route of birth was cesarean section and in this group the gestational body mass index (BMI) was higher.The concentration of IL-1β and IL-6 was high in colostrum of mothers with advanced age compared to adolescent mothers, but did not differ from the control group. Conclusions: The maternal age influenced the socio demographic, gestational and perinatal characteristics of the nursing mothers, as well as the composition of colostrum cytokines. |
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Morceli, Glilcianehttp://lattes.cnpq.br/9829229885197371Lordelo, Eliana Peresihttp://lattes.cnpq.br/2445481664621061Moreli, Jusciele Broginhttp://lattes.cnpq.br/42027977990031938555557856873582http://lattes.cnpq.br/8555557856873582FERRARI, Denise Vasconcelos de Jesus2020-01-14T17:47:38Z2019-02-15FERRARI, Denise Vasconcelos de Jesus. Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva. 2019. Dissertação (Mestrado em Ciências da Saúde) - Universidade do Oeste Paulista, Presidente Prudente, SP, 2019.http://bdtd.unoeste.br:8080/jspui/handle/jspui/1217History: The gestation at the extremes of reproductive ages is characterized as High Risk.The colostrum is the first milk secretion produced and contains the necessary nutrients for the development of the newborn. The objectives were to compare the concentration of IL-1β, IL-6, IL-8, and TNF-α cytokines of adolescent and advanced maternal age mothers colostrum, and to describe demographic, gestational and perinatal socioeconomic characteristics. Methods and results: A cross-sectional study, which included 117 adolescent nursing mothers (up to 24 years of age), 158 nursing mothers of the control group (25 to 34 years), and 39 nursing mothers with advanced maternal age (over 35 years of age) attending the Maternity Hospital of Presidente Prudente. The colostrum samples were obtained by manual milking between 48 and 72 hours post childbirth. The cytokine determination was performed by immunoenzymatic assay (ELISA). The socio-demographic and gestational variables were analyzed by the X² test and the cytokines by the Kruskal-Wallis test, followed by the Dunn test, and the significance level was 5%. The median age in nursing mothers with advanced maternal age was 37 years, statistically superior to the 20-year-old female adolescents. The stable union prevailed among the groups and 81.2% of the adolescent nursing mothers did not exercise gainful activity. In 69.2% of the nursing mothers with advanced maternal age the route of birth was cesarean section and in this group the gestational body mass index (BMI) was higher.The concentration of IL-1β and IL-6 was high in colostrum of mothers with advanced age compared to adolescent mothers, but did not differ from the control group. Conclusions: The maternal age influenced the socio demographic, gestational and perinatal characteristics of the nursing mothers, as well as the composition of colostrum cytokines.Histórico: A gestação nos extremos das idades reprodutivas é caracterizada como de Alto Risco. O colostro é a primeira secreção láctea produzida e contém os nutrientes necessários para o desenvolvimento do neonato. Os objetivos foram comparar a concentração de citocinas IL-1β, IL-6, IL-8, e TNF-α do colostro de nutrizes adolescentes e idade materna avançada e descrever as características sócio demográficas, gestacionais e perinatais. Métodos e resultados: Estudo transversal, que incluiu 117 nutrizes adolescentes (até 24 anos), 158 nutrizes do grupo controle (25 até 34 anos) e 39 nutrizes com idade materna avançada (maior que 35 anos) atendidas na Maternidade do Hospital Regional de Presidente Prudente. As amostras de colostro foram obtidas por meio da ordenha manual entre 48 a 72h após o parto. A determinação de citocinas foi realizada por ensaio imunoenzimático (ELISA). As variáveis sócio demográficas e gestacionas foram analisadas pelo teste de X² e as citocinas pelo teste de Kruskal-Wallis, seguido do teste de Dunn, e o nível de significância foi de 5%. A mediana de idade em nutrizes com idade materna avançada foi de 37 anos, estatisticamente superior às das nutrizes adolescentes com 20 anos. A união estável predominou entre os grupos e 81,2% das nutrizes adolescentes não exerciam atividade remunerada. Em 69,2% das nutrizes com idade materna avançada a via de parto foi a cesárea e neste grupo o índice de massa corporal (IMC) gestacional foi superior. A concentração de IL-1β e IL-6 foi elevada no colostro de mães com idade avançada em comparação às mães adolescentes, porém não diferiu do grupo controle. Conclusões: A idade materna influenciou as características sócio demográficas, gestacionais e perinatais das nutrizes, assim como a composição de citocinas do colostro.Submitted by Jakeline Ortega (jakortega@unoeste.br) on 2020-01-14T17:47:38Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Denise Vasconcelos de Jesus Ferrari.pdf: 496590 bytes, checksum: 90baa235da5c5c66208e89d58c6c47a4 (MD5)Made available in DSpace on 2020-01-14T17:47:38Z (GMT). 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dc.title.por.fl_str_mv |
Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva |
dc.title.alternative.eng.fl_str_mv |
Profile of inflammatory cytokines in colostrum in nursing mothers at the extremes of reproductive age |
title |
Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva |
spellingShingle |
Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva FERRARI, Denise Vasconcelos de Jesus Citocinas inflamatórias Colostro humano Extremos idade Inflammatory cytokines Human colostrum Extremes age CIENCIAS DA SAUDE |
title_short |
Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva |
title_full |
Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva |
title_fullStr |
Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva |
title_full_unstemmed |
Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva |
title_sort |
Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva |
author |
FERRARI, Denise Vasconcelos de Jesus |
author_facet |
FERRARI, Denise Vasconcelos de Jesus |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Morceli, Glilciane |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9829229885197371 |
dc.contributor.referee1.fl_str_mv |
Lordelo, Eliana Peresi |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2445481664621061 |
dc.contributor.referee2.fl_str_mv |
Moreli, Jusciele Brogin |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/4202797799003193 |
dc.contributor.authorID.fl_str_mv |
8555557856873582 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8555557856873582 |
dc.contributor.author.fl_str_mv |
FERRARI, Denise Vasconcelos de Jesus |
contributor_str_mv |
Morceli, Glilciane Lordelo, Eliana Peresi Moreli, Jusciele Brogin |
dc.subject.por.fl_str_mv |
Citocinas inflamatórias Colostro humano Extremos idade |
topic |
Citocinas inflamatórias Colostro humano Extremos idade Inflammatory cytokines Human colostrum Extremes age CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Inflammatory cytokines Human colostrum Extremes age |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
History: The gestation at the extremes of reproductive ages is characterized as High Risk.The colostrum is the first milk secretion produced and contains the necessary nutrients for the development of the newborn. The objectives were to compare the concentration of IL-1β, IL-6, IL-8, and TNF-α cytokines of adolescent and advanced maternal age mothers colostrum, and to describe demographic, gestational and perinatal socioeconomic characteristics. Methods and results: A cross-sectional study, which included 117 adolescent nursing mothers (up to 24 years of age), 158 nursing mothers of the control group (25 to 34 years), and 39 nursing mothers with advanced maternal age (over 35 years of age) attending the Maternity Hospital of Presidente Prudente. The colostrum samples were obtained by manual milking between 48 and 72 hours post childbirth. The cytokine determination was performed by immunoenzymatic assay (ELISA). The socio-demographic and gestational variables were analyzed by the X² test and the cytokines by the Kruskal-Wallis test, followed by the Dunn test, and the significance level was 5%. The median age in nursing mothers with advanced maternal age was 37 years, statistically superior to the 20-year-old female adolescents. The stable union prevailed among the groups and 81.2% of the adolescent nursing mothers did not exercise gainful activity. In 69.2% of the nursing mothers with advanced maternal age the route of birth was cesarean section and in this group the gestational body mass index (BMI) was higher.The concentration of IL-1β and IL-6 was high in colostrum of mothers with advanced age compared to adolescent mothers, but did not differ from the control group. Conclusions: The maternal age influenced the socio demographic, gestational and perinatal characteristics of the nursing mothers, as well as the composition of colostrum cytokines. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-02-15 |
dc.date.accessioned.fl_str_mv |
2020-01-14T17:47:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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dc.identifier.citation.fl_str_mv |
FERRARI, Denise Vasconcelos de Jesus. Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva. 2019. Dissertação (Mestrado em Ciências da Saúde) - Universidade do Oeste Paulista, Presidente Prudente, SP, 2019. |
dc.identifier.uri.fl_str_mv |
http://bdtd.unoeste.br:8080/jspui/handle/jspui/1217 |
identifier_str_mv |
FERRARI, Denise Vasconcelos de Jesus. Perfil de citocinas inflamatórias no colostro em nutrizes nos extremos da idade reprodutiva. 2019. Dissertação (Mestrado em Ciências da Saúde) - Universidade do Oeste Paulista, Presidente Prudente, SP, 2019. |
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http://bdtd.unoeste.br:8080/jspui/handle/jspui/1217 |
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por |
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por |
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500 500 600 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Universidade do Oeste Paulista |
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