Pesquisa de anticorpos anti-Leptospira spp. e anti-Hantavirus em grupos ocupacionais do município de Garanhuns no estado de Pernambuco

• Ano de defesa: 2014
• Autor(a) principal: SILVA, Gesika Maria da
• Orientador(a): PINHEIRO JUNIOR, José Wilton
• Banca de defesa: MOTA, Rinaldo Aparecido, BORGES, Alessandra Abel
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal Rural de Pernambuco
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciência Animal Tropical
• Departamento: Departamento de Morfologia e Fisiologia Animal
• País: Brasil
• Palavras-chave em Português: Epidemiologia; Diagnóstico; Saúde pública; Leptospirose; Hantavirose
• Palavras-chave em Inglês: Diagnosis; Epidemiology; Leptospirosis; Hantavirus; Public health
• Área do conhecimento CNPq: CIENCIAS AGRARIAS::MEDICINA VETERINARIA
• Link de acesso: http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5054

The objective of the present work was to determine the presence of anti-Hantavirus antibodies and anti-Leptospira spp. occupational groups in the municipality of Garanhuns Pernambuco State, Brazil. To perform the serology for Hantavirus and leptospirosis, 156 and 154 samples were obtained, respectively. The method used for the detection of IgG antibodies to Hantavirus N protein was Araraquara in-house ELISA serology and leptospirosis was used technique Microscopic Agglutination Test (MAT). To analyze the risk factors applied a questionnaire with objective questions. The prevalence of anti-Hantavirus Antibodies were 1.9 % (3/156 CI 0.4 %-5.5%) , with two reagent samples with titers of 200 (66.7%) and 400 (33.3%). All seropositive individuals to Hantavirus (100.0%) in this study were male and the village. Regarding age, there was a higher number of seropositive subjects aged between 18 and 40 years (p=0.009). The prevalence of antibodies to Leptospira spp. was 5.2 % (8/154 CI 2.2%-9.9%), a prevalence of 5.7 % (5/88 CI 1.8 %-12 7 % ) participants was observed in the urban area, and countryside of 4.6% (3/66 , CI 0.9%-12.7%). The most common serotypes were the Grippotyphosa (12.5 %) in rural areas and in the urban area autumnalis (12.5 %), while the Wolffi (25.0%) and Australis (50.0%) were observed both in rural areas as in urban. In the analysis of risk factors, no association was observed between these variables and serology. This was the first study conducted in the city of Garanhuns to report the presence of IgG anti-Hantavirus in human serum samples and report the presence of anti-Leptospira spp. in urban and rural workers of the municipality. These findings draw attention to the care and conduct research in areas where there is a low prevalence and even silent areas, because this way of control and prevention measures can be implemented in order to ensure the health of the exposed population.