Efeito da laserterapia no reparo experimental de lesão nervosa periférica após técnica de tubulização preenchida com tecido adiposo

• Ano de defesa: 2018
• Autor(a) principal: Santos, Rafael Francisco de Oliveira
• Orientador(a): Rosa Junior, Geraldo Marco
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Sagrado Coração
• Programa de Pós-Graduação: Saúde Funcional
• Departamento: Ciências da Saúde e Biológicas
• País: Brasil
• Palavras-chave em Português: Lesões Nervosas Periféricas; Regeneração Muscular; Tubulização; Tecido Adiposo; Laserterapia
• Palavras-chave em Inglês: Nerve Injuries; Muscle Regeneration; Tubulization; Adipose Tissue; Laser therapy
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL
• Link de acesso: http://tede2.usc.br:8080/jspui/handle/tede/426

Peripheral nerve injuries are common and can trigger the patient a large sensory and functional loss. In order to minimize this loss and reduce the number of invalid patients, improving their quality of life, many techniques and surgical and postsurgical are studied. The therapy with stem cells derived from adipose tissue is one of them, since they are pluripotent mesenchymal cells with ability to differentiation in several lineages. However, this method still is successfully restricted in vitro, impacting the clinical area because it is an invasive technique, with mutagenesis risks in addition to high costs. Another technique that was used was end-to-end neurorrhaphy, used in there pair of peripheral nerve injuries to the union of the proximal and distal stumps damaged by a suture, but if the distance between the stumps present about 5 cm recommended the use of autologous nerve graft, nerve repair strategy considered the gold standard in humans, however, entail loss sensitive to the patient. As a complementary therapeutic tool, LLLT has gained prominence for being a non-invasive treatment and has positive results in regeneration and functional recovery. This research aimed to evaluate the effect of laser therapy in peripheral nerve injury repair after tubing technique filled with fat. It were used 60 Wistar rats, males, with 80 days of life, supplied by the vivarium of University of Sacred Heart random divided in to six groups of 10 animal search: Control Group (CG), denervated group (GD), tubulization group (GT), tubulization group with fat (GTG), tubing and Laser Group (GTL) and tubing group with fat and Laser (GTGL). The GTG and GTGL groups underwent laser treatment three times a week lasting 90 seconds for 90 days. In the morphometric valuations soleus muscles, extensor digitorum longus and tibial and in the function evaluation the GTGL group obtained the best result. Thus, with the results, it was concluded that the combination of fat in tubulization, as well as the use of laser therapy provided positive results in peripheral nerve repair and functional improvement process.