Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties

Detalhes bibliográficos
Ano de defesa: 2019
Autor(a) principal: Mirela Cardoso Garcia
Orientador(a): André Rolim Baby
Banca de defesa: Marcelo Dutra Duque, Ketylin Fernanda Migliato
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: eng
Instituição de defesa: Universidade de São Paulo
Programa de Pós-Graduação: Fármaco e Medicamentos
Departamento: Não Informado pela instituição
País: BR
Link de acesso: https://doi.org/10.11606/T.9.2019.tde-02102019-120356
Resumo: Ultraviolet radiation (UV) is related to the development of skin cancer and photoaging, also produces free radicals or reactive oxygen species (ROS) that cause premature aging. Therefore, sunscreens with extended UV protection capacity have been studied associated with antioxidant compounds. Different components can be incorporated with the purpose of improving, the photoprotection efficiency, as well as other cosmetic attributes, creating a multifunctional product. Among the compounds, there are some to be used from natural origin that are excellent, because it reduces the side effects and toxicity. Flavonoids are good examples of natural agents, because have demonstrated photoprotective antioxidant action in food and it is also promising for topical use. The aim of this work is to develop photoprotective formulations with quercetin, evaluating potential photoprotective and antioxidant of each formulation through tests already established and described in the literature, with emphasis on in vitro testing of potential photoprotective, antioxidant and security (het-cam); ex vivo antioxidant potential (tape-stripping). The results show us the photoprotective and antioxidant capacity of quercetin and the ideal concentration for this potential, thereby contributing to the synthesis of new molecules and development of new products, concerning stable, safe and effective exposure to solar UV radiation, preventing new incidences of skin cancer and reduction of photoaging.
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties Potencial fotoprotetor / fotoestabilizador de filtros solares associados à quercetina: ensaios físico-químicos e pré-clínicos 2019-07-01André Rolim BabyMarcelo Dutra DuqueKetylin Fernanda MigliatoMirela Cardoso GarciaUniversidade de São PauloFármaco e MedicamentosUSPBR Antioxidant Antioxidante Flavonoid Flavonoide Fotoenvelhecimento Fotoprotetor Photoaging Sunscreen Ultraviolet radiation (UV) is related to the development of skin cancer and photoaging, also produces free radicals or reactive oxygen species (ROS) that cause premature aging. Therefore, sunscreens with extended UV protection capacity have been studied associated with antioxidant compounds. Different components can be incorporated with the purpose of improving, the photoprotection efficiency, as well as other cosmetic attributes, creating a multifunctional product. Among the compounds, there are some to be used from natural origin that are excellent, because it reduces the side effects and toxicity. Flavonoids are good examples of natural agents, because have demonstrated photoprotective antioxidant action in food and it is also promising for topical use. The aim of this work is to develop photoprotective formulations with quercetin, evaluating potential photoprotective and antioxidant of each formulation through tests already established and described in the literature, with emphasis on in vitro testing of potential photoprotective, antioxidant and security (het-cam); ex vivo antioxidant potential (tape-stripping). The results show us the photoprotective and antioxidant capacity of quercetin and the ideal concentration for this potential, thereby contributing to the synthesis of new molecules and development of new products, concerning stable, safe and effective exposure to solar UV radiation, preventing new incidences of skin cancer and reduction of photoaging. A radiação ultravioleta (UV) está relacionada ao desenvolvimento de câncer de pele e fotoenvelhecimento, também produz radicais livres ou espécies reativas de oxigênio (EROs) que causam o envelhecimento precoce. Portanto, protetores solares com capacidade de proteção UV amplo espectro foram estudados associados a compostos antioxidantes. Diferentes componentes podem ser incorporados com o objetivo de melhorar a eficiência da fotoproteção, assim como outros atributos cosméticos criando um produto multifuncional. Entre os compostos a serem utilizados, de origem natural são excelentes, pois reduzem os efeitos colaterais e a toxicidade. Os flavonóides são bons exemplos de agentes naturais, porque demonstraram ação antioxidante fotoprotetora nos alimentos e também são promissores para uso tópico. O objetivo deste trabalho é desenvolver formulações fotoprotetoras com quercetina, avaliando potenciais fotoprotetores e antioxidantes de cada formulação através de testes já estabelecidos e descritos na literatura com ênfase em ensaios in vitro de potenciais fotoprotetores, antioxidantes e de segurança (het-cam); potencial antioxidante ex vivo (tape-stripping). Os resultados nos mostram a capacidade fotoprotetora e antioxidante da quercetina e a concentração ideal para este potencial, contribuindo para a síntese de novas moléculas e desenvolvimento de novos produtos estáveis, seguros e eficazes em relação à exposição à radiação solar UV, prevenindo novas incidências de câncer de pele e redução do fotoenvelhecimento. https://doi.org/10.11606/T.9.2019.tde-02102019-120356info:eu-repo/semantics/openAccessengreponame:Biblioteca Digital de Teses e Dissertações da USPinstname:Universidade de São Paulo (USP)instacron:USP2023-12-21T18:06:07Zoai:teses.usp.br:tde-02102019-120356Biblioteca Digital de Teses e Dissertaçõeshttp://www.teses.usp.br/PUBhttp://www.teses.usp.br/cgi-bin/mtd2br.plvirginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.bropendoar:27212019-11-08T20:22:23Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)false
dc.title.en.fl_str_mv Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties
dc.title.alternative.pt.fl_str_mv Potencial fotoprotetor / fotoestabilizador de filtros solares associados à quercetina: ensaios físico-químicos e pré-clínicos
title Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties
spellingShingle Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties
Mirela Cardoso Garcia
title_short Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties
title_full Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties
title_fullStr Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties
title_full_unstemmed Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties
title_sort Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties
author Mirela Cardoso Garcia
author_facet Mirela Cardoso Garcia
author_role author
dc.contributor.advisor1.fl_str_mv André Rolim Baby
dc.contributor.referee1.fl_str_mv Marcelo Dutra Duque
dc.contributor.referee2.fl_str_mv Ketylin Fernanda Migliato
dc.contributor.author.fl_str_mv Mirela Cardoso Garcia
contributor_str_mv André Rolim Baby
Marcelo Dutra Duque
Ketylin Fernanda Migliato
description Ultraviolet radiation (UV) is related to the development of skin cancer and photoaging, also produces free radicals or reactive oxygen species (ROS) that cause premature aging. Therefore, sunscreens with extended UV protection capacity have been studied associated with antioxidant compounds. Different components can be incorporated with the purpose of improving, the photoprotection efficiency, as well as other cosmetic attributes, creating a multifunctional product. Among the compounds, there are some to be used from natural origin that are excellent, because it reduces the side effects and toxicity. Flavonoids are good examples of natural agents, because have demonstrated photoprotective antioxidant action in food and it is also promising for topical use. The aim of this work is to develop photoprotective formulations with quercetin, evaluating potential photoprotective and antioxidant of each formulation through tests already established and described in the literature, with emphasis on in vitro testing of potential photoprotective, antioxidant and security (het-cam); ex vivo antioxidant potential (tape-stripping). The results show us the photoprotective and antioxidant capacity of quercetin and the ideal concentration for this potential, thereby contributing to the synthesis of new molecules and development of new products, concerning stable, safe and effective exposure to solar UV radiation, preventing new incidences of skin cancer and reduction of photoaging.
publishDate 2019
dc.date.issued.fl_str_mv 2019-07-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.11606/T.9.2019.tde-02102019-120356
url https://doi.org/10.11606/T.9.2019.tde-02102019-120356
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade de São Paulo
dc.publisher.program.fl_str_mv Fármaco e Medicamentos
dc.publisher.initials.fl_str_mv USP
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade de São Paulo
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da USP
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Biblioteca Digital de Teses e Dissertações da USP
collection Biblioteca Digital de Teses e Dissertações da USP
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)
repository.mail.fl_str_mv virginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.br
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