Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica
Ano de defesa: | 2018 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Nove de Julho
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências da Reabilitação
|
Departamento: |
Saúde
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://bibliotecatede.uninove.br/handle/tede/2541 |
Resumo: | The integrations of neural networks represent efficient mechanisms selected by evolution to coordinate physiological homeostasis. It is interesting to note that correlations were demonstrated between cardiovascular and metabolic dysfunctions with autonomic and inflammatory (neuroimmune) disorders. Physical exercise is an important approach to prevent dysfunctions associated with diseases. Thus, recent studies focus on mechanisms induced by exercise to control these dysfunctions. In this thesis, we evaluated the effects of acute or chronic aerobic exercise on neuroimmune dysfunctions induced by experimental models of sepsis or metabolic syndrome. To reach these objectives, we divided the present study into 2 studies. In the first study, we reported that an exercise session of moderate intensity attenuates inflammation and organic dysfunction through dopamine induction mediated by activation of the vagus nerve. Exercise increased serum dopamine levels and adrenalectomy hindered the exercise potential of inducing dopamine and attenuating TNF. The D1 dopaminergic agonist, fenoldopam, inhibited TNF production in splenocytes. On the other hand, the D1-antagonist, butaclamol, prevented control of TNF exercise. In the second study, the consumption of fructose induced impairment in the variability of pulse interval (VAR-IP) since the 7-day protocol. In addition, there was an increased sympathovagal balance at 15, 30 and 60 days of protocol compared to the other groups. TF prevented the observed injury in the VAR-IP with 7 days of protocol, and improved the sympatho-vagal balance (FT vs. F). We observed a reduction in redox balance, protein oxidation as well as reduction of superoxide dismutase enzyme activity in the F groups at 7, 15, 30 and 60 days of protocol in relation to groups C. In addition, the consumption of fructose induced an increase of lipid oxidation at 30 and 60 days (F vs. FT). TF was effective in preventing these losses induced by chronic fructose consumption. In addition, TF prevented the increase of inflammatory mediators (TNF alpha and IL-6) and NF-Kappaβ observed in the fructose groups from 15-30 days of protocol, as well as increased levels of IL- inflammatory). Together our findings reinforce the role of the autonomic nervous system in the genesis of cardiometabolic dysfunctions and show an important role of aerobic physical training in the prevention of these alterations. In conclusion, our results show that neuroimmune dysfunctions occur early in experimental models of sepsis or metabolic syndrome and that aerobic physical exercise of moderate intensity is effective in preventing / attenuating such alterations, impacting on prevention of clinically detectable cardiometabolic alterations in these conditions. However, future studies are needed to determine how different types of exercise regulate different neural networks and their contribution to the cardiovascular, metabolic and immunological benefits induced by exercise. These studies may allow the design of new approaches for the treatment of neuroimmune and cardiometabolic diseases |
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Angelis, Kátia deAngelis, Kátia deJorge, Luciana Maria Malosá SampaioDellê, HumbertoOliveira, Edilamar Menezes deRodrigues, Brunohttp://lattes.cnpq.br/2801204473998788Ferreira, Guilherme Lemos Shimojo2021-06-21T14:38:33Z2018-08-02Ferreira, Guilherme Lemos Shimojo. Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica. 2018. 110 f. Tese( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2541The integrations of neural networks represent efficient mechanisms selected by evolution to coordinate physiological homeostasis. It is interesting to note that correlations were demonstrated between cardiovascular and metabolic dysfunctions with autonomic and inflammatory (neuroimmune) disorders. Physical exercise is an important approach to prevent dysfunctions associated with diseases. Thus, recent studies focus on mechanisms induced by exercise to control these dysfunctions. In this thesis, we evaluated the effects of acute or chronic aerobic exercise on neuroimmune dysfunctions induced by experimental models of sepsis or metabolic syndrome. To reach these objectives, we divided the present study into 2 studies. In the first study, we reported that an exercise session of moderate intensity attenuates inflammation and organic dysfunction through dopamine induction mediated by activation of the vagus nerve. Exercise increased serum dopamine levels and adrenalectomy hindered the exercise potential of inducing dopamine and attenuating TNF. The D1 dopaminergic agonist, fenoldopam, inhibited TNF production in splenocytes. On the other hand, the D1-antagonist, butaclamol, prevented control of TNF exercise. In the second study, the consumption of fructose induced impairment in the variability of pulse interval (VAR-IP) since the 7-day protocol. In addition, there was an increased sympathovagal balance at 15, 30 and 60 days of protocol compared to the other groups. TF prevented the observed injury in the VAR-IP with 7 days of protocol, and improved the sympatho-vagal balance (FT vs. F). We observed a reduction in redox balance, protein oxidation as well as reduction of superoxide dismutase enzyme activity in the F groups at 7, 15, 30 and 60 days of protocol in relation to groups C. In addition, the consumption of fructose induced an increase of lipid oxidation at 30 and 60 days (F vs. FT). TF was effective in preventing these losses induced by chronic fructose consumption. In addition, TF prevented the increase of inflammatory mediators (TNF alpha and IL-6) and NF-Kappaβ observed in the fructose groups from 15-30 days of protocol, as well as increased levels of IL- inflammatory). Together our findings reinforce the role of the autonomic nervous system in the genesis of cardiometabolic dysfunctions and show an important role of aerobic physical training in the prevention of these alterations. In conclusion, our results show that neuroimmune dysfunctions occur early in experimental models of sepsis or metabolic syndrome and that aerobic physical exercise of moderate intensity is effective in preventing / attenuating such alterations, impacting on prevention of clinically detectable cardiometabolic alterations in these conditions. However, future studies are needed to determine how different types of exercise regulate different neural networks and their contribution to the cardiovascular, metabolic and immunological benefits induced by exercise. These studies may allow the design of new approaches for the treatment of neuroimmune and cardiometabolic diseasesAs integrações das redes neurais representam mecanismos eficientes selecionados pela evolução para coordenar a homeostase fisiológica. É interessante notar que correlações foram demonstradas entre disfunções cardiovasculares e metabólicas com alterações autonômicas e inflamatórias (neuroimunes). O exercício físico é um fator importante para prevenir as disfunções associadas as doenças cardiometabolicas. Assim, estudos recentes enfocam nos mecanismos induzidos pelo exercício para controlar essas disfunções. Neste estudo, avaliamos os efeitos do exercício físico aeróbio agudo ou crônico nas disfunções neuroimunes induzidas por modelo experimental de sepse ou de síndrome metabólica. Para atender a estes objetivos separamos o presente trabalho em 2 estudos. No primeiro estudo, relatamos que uma sessão de exercício de intensidade moderada atenua a inflamação e a disfunção orgânica através da indução de dopamina mediada pela ativação do nervo vago. O exercício aumentou os níveis séricos de dopamina e a adrenalectomia impediu o potencial de exercício de induzir a dopamina e atenuar o TNF. O agonista dopaminérgico D1, o fenoldopam, inibiu a produção de TNF em esplenócitos. Por outro lado, o antagonista-D1, butaclamol, impediu o controle do exercício do TNF. No segundo estudo, o consumo de frutose induziu prejuizo na variabilidade do intervalo de pulso (VAR-IP) desde os 7 dias de protocolo. Adicionalmente, houve um aumentou o balanço simpato-vagal em 15, 30 e 60 dias de protocolo em comparação aos demais grupos. O TF preveniu o prejuízo observado na VAR-IP com 7 dias de protocolo, e melhorou o balanço simpato-vagal (FT vs. F). Observamos um prejuízo no balanço redox, na oxidação de proteínas bem como redução da atividade da enzima superóxido dismutase nos grupos F em 7, 15, 30 e 60 dias de protocolo em relação aos grupos C. Somado a isso o consumo de frutose induziu um aumento de oxidação de lipídeos em 30 e 60 dias (F vs. FT). O TF foi eficaz em prevenir esses prejuízos induzidos pelo consumo crônico de frutose. Adicionalmente, o TF preveniu o aumento de mediadores inflamatórios (TNF alfa e IL-6) e de NF-Kappa β observado nos grupos frutose a partir de 15-30 dias de protocolo, bem como aumentou os níveis de IL-10 (anti-inflamatório). Em conjunto nossos achados reforçam o papel do sistema nervoso autônomo na gênese das disfunções cardiometabólicas e evidenciam um importante papel do treinamento físico aeróbio na prevenção dessas alterações. Concluindo, nossos resultados evidenciam que as disfunções neuroimunes ocorrem precocemente em modelos experimentais de sepse ou de síndrome metabólica e que o exercício físico aeróbio de intensidade moderada é eficaz em prevenir/atenuar tais alterações impactando em prevenção de alterações cardiometabólicas clinicamente detectáveis nestas condições. No entanto, estudos futuros são necessários para determinar como diferentes tipos de exercício regulam diferentes redes neuronais e sua contribuição para os benefícios cardiovasculares, metabólicos e imunológicos induzidos pelo exercício físico. Estes estudos poderão permitir a concepção de novas abordagens para o tratamento de doenças neuroimunes e cardiometabólicas.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-06-21T14:38:33Z No. of bitstreams: 1 Guilherme Lemos Shimojo Ferreira.pdf: 3424986 bytes, checksum: d1c529fde3157c0751074b4263f088c1 (MD5)Made available in DSpace on 2021-06-21T14:38:33Z (GMT). No. of bitstreams: 1 Guilherme Lemos Shimojo Ferreira.pdf: 3424986 bytes, checksum: d1c529fde3157c0751074b4263f088c1 (MD5) Previous issue date: 2018-08-02application/pdfporUniversidade Nove de JulhoPrograma de Pós-Graduação em Ciências da ReabilitaçãoUNINOVEBrasilSaúdeexercício físico aeróbiosepsesíndrome metabólicasistema nervoso autônomoinflamaçãoestresse oxidativoaerobic exercisesepsismetabolic syndromeautonomic nervous systeminflammationoxidative stressCIENCIAS DA SAUDEPapel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólicaRole of phisical exercise in the neuroimmune dysfunctions modulating: evaluations in an experimental model of sepsis and metabolic syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALGuilherme Lemos Shimojo Ferreira.pdfGuilherme Lemos Shimojo Ferreira.pdfapplication/pdf3424986http://localhost:8080/tede/bitstream/tede/2541/2/Guilherme+Lemos+Shimojo+Ferreira.pdfd1c529fde3157c0751074b4263f088c1MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2541/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/25412021-06-21 11:38:33.613oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2021-06-21T14:38:33Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica |
dc.title.alternative.eng.fl_str_mv |
Role of phisical exercise in the neuroimmune dysfunctions modulating: evaluations in an experimental model of sepsis and metabolic syndrome |
title |
Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica |
spellingShingle |
Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica Ferreira, Guilherme Lemos Shimojo exercício físico aeróbio sepse síndrome metabólica sistema nervoso autônomo inflamação estresse oxidativo aerobic exercise sepsis metabolic syndrome autonomic nervous system inflammation oxidative stress CIENCIAS DA SAUDE |
title_short |
Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica |
title_full |
Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica |
title_fullStr |
Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica |
title_full_unstemmed |
Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica |
title_sort |
Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica |
author |
Ferreira, Guilherme Lemos Shimojo |
author_facet |
Ferreira, Guilherme Lemos Shimojo |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Angelis, Kátia de |
dc.contributor.referee1.fl_str_mv |
Angelis, Kátia de |
dc.contributor.referee2.fl_str_mv |
Jorge, Luciana Maria Malosá Sampaio |
dc.contributor.referee3.fl_str_mv |
Dellê, Humberto |
dc.contributor.referee4.fl_str_mv |
Oliveira, Edilamar Menezes de |
dc.contributor.referee5.fl_str_mv |
Rodrigues, Bruno |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2801204473998788 |
dc.contributor.author.fl_str_mv |
Ferreira, Guilherme Lemos Shimojo |
contributor_str_mv |
Angelis, Kátia de Angelis, Kátia de Jorge, Luciana Maria Malosá Sampaio Dellê, Humberto Oliveira, Edilamar Menezes de Rodrigues, Bruno |
dc.subject.por.fl_str_mv |
exercício físico aeróbio sepse síndrome metabólica sistema nervoso autônomo inflamação estresse oxidativo |
topic |
exercício físico aeróbio sepse síndrome metabólica sistema nervoso autônomo inflamação estresse oxidativo aerobic exercise sepsis metabolic syndrome autonomic nervous system inflammation oxidative stress CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
aerobic exercise sepsis metabolic syndrome autonomic nervous system inflammation oxidative stress |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
The integrations of neural networks represent efficient mechanisms selected by evolution to coordinate physiological homeostasis. It is interesting to note that correlations were demonstrated between cardiovascular and metabolic dysfunctions with autonomic and inflammatory (neuroimmune) disorders. Physical exercise is an important approach to prevent dysfunctions associated with diseases. Thus, recent studies focus on mechanisms induced by exercise to control these dysfunctions. In this thesis, we evaluated the effects of acute or chronic aerobic exercise on neuroimmune dysfunctions induced by experimental models of sepsis or metabolic syndrome. To reach these objectives, we divided the present study into 2 studies. In the first study, we reported that an exercise session of moderate intensity attenuates inflammation and organic dysfunction through dopamine induction mediated by activation of the vagus nerve. Exercise increased serum dopamine levels and adrenalectomy hindered the exercise potential of inducing dopamine and attenuating TNF. The D1 dopaminergic agonist, fenoldopam, inhibited TNF production in splenocytes. On the other hand, the D1-antagonist, butaclamol, prevented control of TNF exercise. In the second study, the consumption of fructose induced impairment in the variability of pulse interval (VAR-IP) since the 7-day protocol. In addition, there was an increased sympathovagal balance at 15, 30 and 60 days of protocol compared to the other groups. TF prevented the observed injury in the VAR-IP with 7 days of protocol, and improved the sympatho-vagal balance (FT vs. F). We observed a reduction in redox balance, protein oxidation as well as reduction of superoxide dismutase enzyme activity in the F groups at 7, 15, 30 and 60 days of protocol in relation to groups C. In addition, the consumption of fructose induced an increase of lipid oxidation at 30 and 60 days (F vs. FT). TF was effective in preventing these losses induced by chronic fructose consumption. In addition, TF prevented the increase of inflammatory mediators (TNF alpha and IL-6) and NF-Kappaβ observed in the fructose groups from 15-30 days of protocol, as well as increased levels of IL- inflammatory). Together our findings reinforce the role of the autonomic nervous system in the genesis of cardiometabolic dysfunctions and show an important role of aerobic physical training in the prevention of these alterations. In conclusion, our results show that neuroimmune dysfunctions occur early in experimental models of sepsis or metabolic syndrome and that aerobic physical exercise of moderate intensity is effective in preventing / attenuating such alterations, impacting on prevention of clinically detectable cardiometabolic alterations in these conditions. However, future studies are needed to determine how different types of exercise regulate different neural networks and their contribution to the cardiovascular, metabolic and immunological benefits induced by exercise. These studies may allow the design of new approaches for the treatment of neuroimmune and cardiometabolic diseases |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-08-02 |
dc.date.accessioned.fl_str_mv |
2021-06-21T14:38:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Ferreira, Guilherme Lemos Shimojo. Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica. 2018. 110 f. Tese( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2541 |
identifier_str_mv |
Ferreira, Guilherme Lemos Shimojo. Papel do exercício físico aeróbio na modulação das disfunções neuroimunes: avaliações em modelo experimental de sepse e de síndrome metabólica. 2018. 110 f. Tese( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, São Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/2541 |
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Programa de Pós-Graduação em Ciências da Reabilitação |
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UNINOVE |
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bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE) |
repository.mail.fl_str_mv |
bibliotecatede@uninove.br||bibliotecatede@uninove.br |
_version_ |
1797250763220582400 |