Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido
Ano de defesa: | 2014 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Nove de Julho
|
Programa de Pós-Graduação: |
Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o
|
Departamento: |
Sa??de
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://bibliotecatede.uninove.br/tede/handle/tede/908 |
Resumo: | The aim of this study was to evaluate effects of the ovarian hormones deprivation associated with hypertension and fructose overload in metabolic, cardiovascular, autonomic, inflammation and oxidative stress parameters. Additionally aimed to investigate the effects of the dynamic or resistance exercise training this condition by association of the risk factors. Female rats Wistar (n=8) and SHR (n=32) were divided in: normotensive (C), hypertensive (H), hypertensive ovariectomized (HO), hypertensive ovariectomized treated with fructose (FHO), and submitted aerobic exercise training (FHOTa) or resistance exercise training (FHOTr). The aerobic exercise training (treadmill; 1h/day; 5d/wk) and resistance exercise training (ladder adaptated for rats; 1h/day; 5d/wk) were performed during 8 weeks. Cardiovascular function, autonomic cardiovascular modulation, metabolic and physical capacity were evaluated, as weel as the relationship of these variables with cardiac oxidative stress and inflammation in the cardiac and renal tissues. The association of risk factors promoted an exarcebated increase in blood pressure (FHO: 173??1 vs. C:108??1 mmHg). In contrast, was observed resting bradycardia after exercise training (FHO: 393??10 vs. FHOTa:336??9 and FHOTr:330??13bpm). The FHO group showed impairment in the pressoreceptors sensibility, autonomic modulation and lower nitric oxide bioavaliability. Both aerobic and resistance exercise training normalized the RMSSD (parasympathetic modulation index) and increased the pressoreceptors sensibility. TNF alpha and leptin were increased in the FHO group (65.8??9.9 pg/mg protein and 1346.65??127.28pg/ml) in relation to C group (23.66??4.35 pg/mg protein and 974.28??90.90 pg/ml), which was normalized of the trainings. Correlation between TNF alpha and leptin (positive) was obtained in the treated with fructose groups (sedentary and trained). On the other hand, the exercise training promoted higher nitric oxide bioavaliability (FHOTa:0.32??0.2; FHOTr:1.46??0.18 vs. FHO:1.35??0.21 C:1.1??0.15 nmol/mg protein) and increase oh the IL-10 (only FHOTr: 40.25??7.97 vs. FHO:16.26??2.52pg/mg protein). Positive correlation was obtained between RMSSD and IL-10. The fructose overload induced an increase membrane lipoperoxidation in the cardiac tissue (FHO:15043??1333; FHOTa:10652??814; FHOTr:11551??1350 vs. C:2661??358??lmol/mg protein), which was reduced by both types of the training. The FHO group showed increase proteins damage in the renal tissue (FHO:4.40??0.37 vs. C: 1.97??0.21nmol/mg protein) and both exercise training were effective in decrease this variable. Negative correlation was obtained between cardiac RMSSD and QL. Positive correlation was obtained between renal LF-PAS and TBARS. Fructose overload reduced the cardiac TRAP, however, both exercise training enhance this variable. Fructose consumption induced impairment in the redox balance (FHO: 8.2??0.51 vs. C:10.4??0.63), which can be reversed by aerobic (FHOTa: 12.9??0.44) and resistance exercise training (FHOTr:). The redox balance was positively related with RMSSD and negatively correlated with TNF alpha. Concluding, the results evidences that fructose overload induced impairment in the cardiovascular autonomic modulation associated increase inflammatory and oxidative stress parameters in hypertensive ovariectomized rats. Dynamic aerobic or resistance exercise training of the moderate intensity this model of risk factors association attenuated some of the metabolic, cardiovascular and autonomic dysfunctions probably by improving inflammatory markers and oxidative stress. |
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Angelis, K??tia dehttp://lattes.cnpq.br/4299344810509965Irigoyen, Maria Claudia Costahttp://lattes.cnpq.br/8049184468038869Zamuner, Stella Reginahttp://lattes.cnpq.br/1935805744318404Cavaglieri, Claudia Reginahttp://lattes.cnpq.br/9330989884789830Silva, Ivana Cinthya de Moraes dahttp://lattes.cnpq.br/2425669777101427CPF:34479537805http://lattes.cnpq.br/5106100358268027Brito, Janaina de Oliveira2015-04-22T17:20:46Z2014-12-032014-02-27BRITO, Janaina de Oliveira. Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido. 2014. 181 f. Tese (Doutorado em Sa??de) - Universidade Nove de Julho, S??o Paulo, 2014.http://bibliotecatede.uninove.br/tede/handle/tede/908The aim of this study was to evaluate effects of the ovarian hormones deprivation associated with hypertension and fructose overload in metabolic, cardiovascular, autonomic, inflammation and oxidative stress parameters. Additionally aimed to investigate the effects of the dynamic or resistance exercise training this condition by association of the risk factors. Female rats Wistar (n=8) and SHR (n=32) were divided in: normotensive (C), hypertensive (H), hypertensive ovariectomized (HO), hypertensive ovariectomized treated with fructose (FHO), and submitted aerobic exercise training (FHOTa) or resistance exercise training (FHOTr). The aerobic exercise training (treadmill; 1h/day; 5d/wk) and resistance exercise training (ladder adaptated for rats; 1h/day; 5d/wk) were performed during 8 weeks. Cardiovascular function, autonomic cardiovascular modulation, metabolic and physical capacity were evaluated, as weel as the relationship of these variables with cardiac oxidative stress and inflammation in the cardiac and renal tissues. The association of risk factors promoted an exarcebated increase in blood pressure (FHO: 173??1 vs. C:108??1 mmHg). In contrast, was observed resting bradycardia after exercise training (FHO: 393??10 vs. FHOTa:336??9 and FHOTr:330??13bpm). The FHO group showed impairment in the pressoreceptors sensibility, autonomic modulation and lower nitric oxide bioavaliability. Both aerobic and resistance exercise training normalized the RMSSD (parasympathetic modulation index) and increased the pressoreceptors sensibility. TNF alpha and leptin were increased in the FHO group (65.8??9.9 pg/mg protein and 1346.65??127.28pg/ml) in relation to C group (23.66??4.35 pg/mg protein and 974.28??90.90 pg/ml), which was normalized of the trainings. Correlation between TNF alpha and leptin (positive) was obtained in the treated with fructose groups (sedentary and trained). On the other hand, the exercise training promoted higher nitric oxide bioavaliability (FHOTa:0.32??0.2; FHOTr:1.46??0.18 vs. FHO:1.35??0.21 C:1.1??0.15 nmol/mg protein) and increase oh the IL-10 (only FHOTr: 40.25??7.97 vs. FHO:16.26??2.52pg/mg protein). Positive correlation was obtained between RMSSD and IL-10. The fructose overload induced an increase membrane lipoperoxidation in the cardiac tissue (FHO:15043??1333; FHOTa:10652??814; FHOTr:11551??1350 vs. C:2661??358??lmol/mg protein), which was reduced by both types of the training. The FHO group showed increase proteins damage in the renal tissue (FHO:4.40??0.37 vs. C: 1.97??0.21nmol/mg protein) and both exercise training were effective in decrease this variable. Negative correlation was obtained between cardiac RMSSD and QL. Positive correlation was obtained between renal LF-PAS and TBARS. Fructose overload reduced the cardiac TRAP, however, both exercise training enhance this variable. Fructose consumption induced impairment in the redox balance (FHO: 8.2??0.51 vs. C:10.4??0.63), which can be reversed by aerobic (FHOTa: 12.9??0.44) and resistance exercise training (FHOTr:). The redox balance was positively related with RMSSD and negatively correlated with TNF alpha. Concluding, the results evidences that fructose overload induced impairment in the cardiovascular autonomic modulation associated increase inflammatory and oxidative stress parameters in hypertensive ovariectomized rats. Dynamic aerobic or resistance exercise training of the moderate intensity this model of risk factors association attenuated some of the metabolic, cardiovascular and autonomic dysfunctions probably by improving inflammatory markers and oxidative stress.O objetivo do presente estudo foi avaliar os efeitos da priva????o dos horm??nios ovarianos associado ?? hipertens??o e ao consumo cr??nico de frutose em par??metros metab??licos, cardiovasculares, auton??micos, de inflama????o e de estresse oxidativo. Adicionalmente, objetivou-se investigar os efeitos do treinamento f??sico din??mico aer??bio ou resistido nessa condi????o de associa????o de fatores de risco. Ratas f??meas Wistar (n=8) e SHR (n=32) foram divididas em: normotensas (C), hipertensas (H), hipertensas ooforectomizadas (HO), hipertensas ooforectomizadas tratadas com frutose (FHO) submetidas ao treinamento f??sico aer??bio (FHOTa) ou treinamento f??sico resistido (FHOTr). O treinamento f??sico aer??bio (esteira; 1h/dia; 5x/sem) e o treinamento f??sico resistido (escada adaptada para ratos; 1h/dia; 5x/sem) foram realizados durante 8 semanas. Par??metros de fun????o cardiovascular, de regula????o auton??mica cardiovascular, metab??licos e de capacidade f??sica e sua rela????o com altera????es de estresse oxidativo e de inflama????o foram avaliados no tecido card??aco e renal. A somat??ria dos fatores de risco promoveu aumento exacerbado nos n??veis press??ricos (FHO:173??1 vs. C:108??1 mmHg). Em contrapartida, foi observado a bradicardia de repouso ap??s o treinamento f??sico (FHO:393??10 vs. FHOTa:336??9 e FHOTr:330??13bpm). O grupo FHO apresentou preju??zo na sensibilidade dos pressorreceptores, na modula????o auton??mica cardiovascular e menor biodisponibilidade de ??xido n??trico. Tanto o treinamento f??sico aer??bio quanto o resistido normalizou o RMSSD (??ndice de modula????o parassimp??tica) e aumentou a sensibilidade dos pressorreceptores. O TNF alfa e a leptina estavam aumentados no grupo FHO (65,8??9,9 pg/mg prote??na e 1346,65??127,28pg/ml) em rela????o ao grupo C (23,66??4,35 pg/mg prote??na e 974,28??90,90 pg/ml), o que foi normalizado pelos treinamentos. Correla????o entre TNF alfa e leptina (positiva) foi obtida nos grupos tratados com frutose (sedent??rios e treinados). Por outro lado, o treinamento f??sico promoveu maior biodisponibilidade de ??xido n??trico (FHOTa:0,32??0,2; FHOTr:1,46??0,18 vs. FHO:1,35??0,21 C:1,1??0,15 nmol/mg de prote??na) e aumento da IL-10 (somente FHOTr: 40,25??7,97 vs. FHO:16,26??2,52pg/mg prote??na). Correla????o positiva foi obtida entre o RMSSD e a IL-10. A sobrecarga de frutose induziu um aumento da lipoperoxida????o de membrana no tecido card??aco (FHO:15043??1333; FHOTa:10652??814; FHOTr:11551??1350 vs. C:2661??358??lmol/mg prote??na), o qual foi reduzido por ambos os tipos de treinamento. O grupo HOF apresentou aumento de dano ?? prote??na no tecido renal (FHO:4,40??0,37 vs. C: 1,97??0,21nmol/mg prote??na), e ambos os treinamentos foram eficazes em diminuir essa vari??vel. Correla????o negativa foi obtida entre o RMSSD e a QL card??aca. Correla????o positiva foi obtida entre BF-PAS e o TBARS renal. A sobrecarga de frutose reduziu a TRAP card??aca, entretanto ambos os tipos de treinamento f??sico aumentaram essa vari??vel. O consumo de frutose induziu preju??zo no balan??o redox (FHO: 8,2??0,51 vs. C: 10,4??0,63), o qual pode ser revertido pelo treinamento aer??bio (FHOTa: 12,9??0,44) e resistido (FHOTr:). O balan??o redox foi positivamente relacionado com o RMSSD e negativamente correlacionado com o TNF alfa. Concluindo, os resultados evidenciam que a sobrecarga de frutose induziu preju??zo da modula????o auton??mica cardiovascular associado ao aumento de par??metros inflamat??rios e de estresse oxidativo em ratas ovariectomizadas hipertensas. O treinamento f??sico din??mico aer??bio ou resistido de intensidade moderada neste modelo de associa????o de fatores de risco atenuou algumas das disfun????es metab??licas, cardiovasculares e auton??micas provavelmente por melhorar o perfil de marcadores inflamat??rio e o estresse oxidativo.Made available in DSpace on 2015-04-22T17:20:46Z (GMT). No. of bitstreams: 1 Janaina de Oliveira Brito.pdf: 9648844 bytes, checksum: f180732f4d279c4e3802fc6a13d30946 (MD5) Previous issue date: 2014-02-27application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Ci??ncias da Reabilita????oUNINOVEBRSa??dehipertens??omenopausas??ndrome metab??licamodula????o auton??micaestresse oxidativomarcadores inflamat??rioshypertensionmenopausemetabolic syndromeautonomic modulationoxidative stressinflammatory markersCIENCIAS DA SAUDEMecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistidoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALJanaina de Oliveira Brito.pdfapplication/pdf9648844http://localhost:8080/tede/bitstream/tede/908/1/Janaina+de+Oliveira+Brito.pdff180732f4d279c4e3802fc6a13d30946MD51tede/9082018-06-15 12:49:13.225oai:localhost:tede/908Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2018-06-15T15:49:13Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido |
title |
Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido |
spellingShingle |
Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido Brito, Janaina de Oliveira hipertens??o menopausa s??ndrome metab??lica modula????o auton??mica estresse oxidativo marcadores inflamat??rios hypertension menopause metabolic syndrome autonomic modulation oxidative stress inflammatory markers CIENCIAS DA SAUDE |
title_short |
Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido |
title_full |
Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido |
title_fullStr |
Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido |
title_full_unstemmed |
Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido |
title_sort |
Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido |
author |
Brito, Janaina de Oliveira |
author_facet |
Brito, Janaina de Oliveira |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Angelis, K??tia de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4299344810509965 |
dc.contributor.referee1.fl_str_mv |
Irigoyen, Maria Claudia Costa |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/8049184468038869 |
dc.contributor.referee2.fl_str_mv |
Zamuner, Stella Regina |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/1935805744318404 |
dc.contributor.referee3.fl_str_mv |
Cavaglieri, Claudia Regina |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/9330989884789830 |
dc.contributor.referee4.fl_str_mv |
Silva, Ivana Cinthya de Moraes da |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/2425669777101427 |
dc.contributor.authorID.fl_str_mv |
CPF:34479537805 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5106100358268027 |
dc.contributor.author.fl_str_mv |
Brito, Janaina de Oliveira |
contributor_str_mv |
Angelis, K??tia de Irigoyen, Maria Claudia Costa Zamuner, Stella Regina Cavaglieri, Claudia Regina Silva, Ivana Cinthya de Moraes da |
dc.subject.por.fl_str_mv |
hipertens??o menopausa s??ndrome metab??lica modula????o auton??mica estresse oxidativo marcadores inflamat??rios |
topic |
hipertens??o menopausa s??ndrome metab??lica modula????o auton??mica estresse oxidativo marcadores inflamat??rios hypertension menopause metabolic syndrome autonomic modulation oxidative stress inflammatory markers CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
hypertension menopause metabolic syndrome autonomic modulation oxidative stress inflammatory markers |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
The aim of this study was to evaluate effects of the ovarian hormones deprivation associated with hypertension and fructose overload in metabolic, cardiovascular, autonomic, inflammation and oxidative stress parameters. Additionally aimed to investigate the effects of the dynamic or resistance exercise training this condition by association of the risk factors. Female rats Wistar (n=8) and SHR (n=32) were divided in: normotensive (C), hypertensive (H), hypertensive ovariectomized (HO), hypertensive ovariectomized treated with fructose (FHO), and submitted aerobic exercise training (FHOTa) or resistance exercise training (FHOTr). The aerobic exercise training (treadmill; 1h/day; 5d/wk) and resistance exercise training (ladder adaptated for rats; 1h/day; 5d/wk) were performed during 8 weeks. Cardiovascular function, autonomic cardiovascular modulation, metabolic and physical capacity were evaluated, as weel as the relationship of these variables with cardiac oxidative stress and inflammation in the cardiac and renal tissues. The association of risk factors promoted an exarcebated increase in blood pressure (FHO: 173??1 vs. C:108??1 mmHg). In contrast, was observed resting bradycardia after exercise training (FHO: 393??10 vs. FHOTa:336??9 and FHOTr:330??13bpm). The FHO group showed impairment in the pressoreceptors sensibility, autonomic modulation and lower nitric oxide bioavaliability. Both aerobic and resistance exercise training normalized the RMSSD (parasympathetic modulation index) and increased the pressoreceptors sensibility. TNF alpha and leptin were increased in the FHO group (65.8??9.9 pg/mg protein and 1346.65??127.28pg/ml) in relation to C group (23.66??4.35 pg/mg protein and 974.28??90.90 pg/ml), which was normalized of the trainings. Correlation between TNF alpha and leptin (positive) was obtained in the treated with fructose groups (sedentary and trained). On the other hand, the exercise training promoted higher nitric oxide bioavaliability (FHOTa:0.32??0.2; FHOTr:1.46??0.18 vs. FHO:1.35??0.21 C:1.1??0.15 nmol/mg protein) and increase oh the IL-10 (only FHOTr: 40.25??7.97 vs. FHO:16.26??2.52pg/mg protein). Positive correlation was obtained between RMSSD and IL-10. The fructose overload induced an increase membrane lipoperoxidation in the cardiac tissue (FHO:15043??1333; FHOTa:10652??814; FHOTr:11551??1350 vs. C:2661??358??lmol/mg protein), which was reduced by both types of the training. The FHO group showed increase proteins damage in the renal tissue (FHO:4.40??0.37 vs. C: 1.97??0.21nmol/mg protein) and both exercise training were effective in decrease this variable. Negative correlation was obtained between cardiac RMSSD and QL. Positive correlation was obtained between renal LF-PAS and TBARS. Fructose overload reduced the cardiac TRAP, however, both exercise training enhance this variable. Fructose consumption induced impairment in the redox balance (FHO: 8.2??0.51 vs. C:10.4??0.63), which can be reversed by aerobic (FHOTa: 12.9??0.44) and resistance exercise training (FHOTr:). The redox balance was positively related with RMSSD and negatively correlated with TNF alpha. Concluding, the results evidences that fructose overload induced impairment in the cardiovascular autonomic modulation associated increase inflammatory and oxidative stress parameters in hypertensive ovariectomized rats. Dynamic aerobic or resistance exercise training of the moderate intensity this model of risk factors association attenuated some of the metabolic, cardiovascular and autonomic dysfunctions probably by improving inflammatory markers and oxidative stress. |
publishDate |
2014 |
dc.date.available.fl_str_mv |
2014-12-03 |
dc.date.issued.fl_str_mv |
2014-02-27 |
dc.date.accessioned.fl_str_mv |
2015-04-22T17:20:46Z |
dc.type.status.fl_str_mv |
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doctoralThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
BRITO, Janaina de Oliveira. Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido. 2014. 181 f. Tese (Doutorado em Sa??de) - Universidade Nove de Julho, S??o Paulo, 2014. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/tede/handle/tede/908 |
identifier_str_mv |
BRITO, Janaina de Oliveira. Mecanismos associados ??s disfun????es cardiometab??licas em um modelo experimental de menopausa e s??ndrome metab??lica: papel do treinamento f??sico aer??bio ou resistido. 2014. 181 f. Tese (Doutorado em Sa??de) - Universidade Nove de Julho, S??o Paulo, 2014. |
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http://bibliotecatede.uninove.br/tede/handle/tede/908 |
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