Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica
Ano de defesa: | 2018 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Estadual de Feira de Santana
|
Programa de Pós-Graduação: |
Doutorado Acad?mico em Biotecnologia
|
Departamento: |
DEPARTAMENTO DE CI?NCIAS BIOL?GICAS
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://tede2.uefs.br:8080/handle/tede/721 |
Resumo: | Chronic pain associated with non-inflammatory and neuropathic states is prevalent and debilitating, and still remains without an efficient and safe treatment. For this purpose, this study was designed to investigate the antihyperalgesic effect of free and complexed Lippia grata essential oil on ?-cyclodextrin (OEL/?CD) in animal models of chronic noninflammatory pain (fibromyalgia) and neuropathic pain. In this study, it was possible to demonstrate strong experimental evidence of how ?-cyclodextrin can act as a safe and low cost drug complexation system, improving the pharmacological properties of terpenes, transforming these natural products into an attractive choice for pharmacological use. In a systematic review, selecting the species of Lippia with properties on the central nervous system, this study observed that although several species present analgesic activity few studies have explored the mechanism of action responsible for these effects or have made a detailed phytochemical description or even investigated the toxicity and/or therapeutic safety of continued use of these drugs. Despite this, the results of the extracts and oils analyzes were consistent with most reports of ethnopharmacological studies reaffirming the importance of folk medicine as a guide for such studies. Using a non-inflammatory muscle pain model, this study demonstrated that OEL/?CD reduced primary and secondary hyperalgesia without altering muscle strength. It attributed these effects to the possible involvement of opiodergic and serotonergic receptors, corroborating the hypothesis of involvement of the pain inhibitory descending pathway supported by in silico study and the expression of the Fos protein in the dorsal horn of the medulla, in addition to the antioxidant activity demonstrated by OEL and OEL/?CD. The mechanical and thermal anti-hyperalgesic action of OEL and OEL/?CD (24mg / kg) in neuropathic pain (partial sciatic nerve ligation) and persistent inflammatory pain (CFA) models was also investigated. The attenuated migration of leukocytes associated with reduced levels of TNF-? and IL-1? observed in the pleurisy model may suggest the reduction of hyperalgesia and edema caused by the intraplantar injection of CFA observed after oral treatment with OEL and OEL/?CD. This treatment also reduced the development of mechanical and thermal hyperalgesia unleashed by the partial sciatic nerve ligation. Reduction of TNF-? levels in the sciatic nerve and medulla as well as phosphorylation of NF?B and PKA in these same tissues suggest a positive correlation between the action of the oil and the reduction of the algic effect of these mediators. The OEL (24mg/kg) and OEL/?CD (24mg/kg) did not inhibit the intraplantar injection-induced nociception of cinnamaldehyde (TRPA1 agonist) and menthol (TRPM8 agonist). The acute and prolonged oral treatment OEL and OEL-?CD (24 mg / kg) did not alter the motor activity of the animals. The results indicated that OEL/?CD (24mg/kg) may be potentially interesting for the development of drugs clinically relevant for the treatment of chronic pain disorders. |
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Lucchese, Ang?lica Maria3968463609195974423534http://lattes.cnpq.br/0651476820928653Lima, Pollyana de Souza Siqueira2019-02-11T23:19:30Z2018-03-23LIMA, Pollyana de Souza Siqueira. Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica. 2018. 188 f. Tese (Doutorado Acad?mico em Biotecnologia) - Universidade Estadual de Feira de Santana, Feira de Santana, 2018.http://tede2.uefs.br:8080/handle/tede/721Chronic pain associated with non-inflammatory and neuropathic states is prevalent and debilitating, and still remains without an efficient and safe treatment. For this purpose, this study was designed to investigate the antihyperalgesic effect of free and complexed Lippia grata essential oil on ?-cyclodextrin (OEL/?CD) in animal models of chronic noninflammatory pain (fibromyalgia) and neuropathic pain. In this study, it was possible to demonstrate strong experimental evidence of how ?-cyclodextrin can act as a safe and low cost drug complexation system, improving the pharmacological properties of terpenes, transforming these natural products into an attractive choice for pharmacological use. In a systematic review, selecting the species of Lippia with properties on the central nervous system, this study observed that although several species present analgesic activity few studies have explored the mechanism of action responsible for these effects or have made a detailed phytochemical description or even investigated the toxicity and/or therapeutic safety of continued use of these drugs. Despite this, the results of the extracts and oils analyzes were consistent with most reports of ethnopharmacological studies reaffirming the importance of folk medicine as a guide for such studies. Using a non-inflammatory muscle pain model, this study demonstrated that OEL/?CD reduced primary and secondary hyperalgesia without altering muscle strength. It attributed these effects to the possible involvement of opiodergic and serotonergic receptors, corroborating the hypothesis of involvement of the pain inhibitory descending pathway supported by in silico study and the expression of the Fos protein in the dorsal horn of the medulla, in addition to the antioxidant activity demonstrated by OEL and OEL/?CD. The mechanical and thermal anti-hyperalgesic action of OEL and OEL/?CD (24mg / kg) in neuropathic pain (partial sciatic nerve ligation) and persistent inflammatory pain (CFA) models was also investigated. The attenuated migration of leukocytes associated with reduced levels of TNF-? and IL-1? observed in the pleurisy model may suggest the reduction of hyperalgesia and edema caused by the intraplantar injection of CFA observed after oral treatment with OEL and OEL/?CD. This treatment also reduced the development of mechanical and thermal hyperalgesia unleashed by the partial sciatic nerve ligation. Reduction of TNF-? levels in the sciatic nerve and medulla as well as phosphorylation of NF?B and PKA in these same tissues suggest a positive correlation between the action of the oil and the reduction of the algic effect of these mediators. The OEL (24mg/kg) and OEL/?CD (24mg/kg) did not inhibit the intraplantar injection-induced nociception of cinnamaldehyde (TRPA1 agonist) and menthol (TRPM8 agonist). The acute and prolonged oral treatment OEL and OEL-?CD (24 mg / kg) did not alter the motor activity of the animals. The results indicated that OEL/?CD (24mg/kg) may be potentially interesting for the development of drugs clinically relevant for the treatment of chronic pain disorders.As dores cr?nicas associadas a estados n?o inflamat?rios e neurop?ticos s?o prevalentes e debilitantes permanecendo ainda sem um tratamento eficiente e seguro. Para tanto, este estudo foi delineado com o intuito de investigar atrav?s de ensaios funcionais e moleculares, o efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexada em ?-ciclodextrina (OEL/?-CD) em modelos animais de dor cr?nica n?o inflamat?ria (fibromialgia) e dor neurop?tica. Neste estudo foi poss?vel demonstrar fortes evid?ncias experimentais de como a ?-ciclodextrina pode agir como um sistema de complexa??o de drogas seguro e de baixo custo, melhorando as propriedades farmacol?gicas dos terpenos, transforrnando estes produtos naturais em uma escolha atrativa para uso farmacol?gico. Ao realizar uma revis?o sistem?tica, selecionando as esp?cies de Lippia com propriedades sobre o sistema nervoso central, este estudo observou que apesar de v?rias esp?cies apresentarem atividade analg?sica poucos estudos exploraram o mecanismo de a??o respons?veis por estes efeitos ou fizeram uma descri??o fitoqu?mica detalhada ou ainda investigaram a toxicidade e/ou seguran?a terap?utica do uso continuado destas drogas. Apesar disto, os resultados das an?lises de extratos e ?leos foram consistentes com a maioria dos relatos dos estudos etnofarmacol?gicos reafirmando a import?ncia da medicina popular como guia para tais estudos. Utilizando um modelo de dor muscular n?o inflamat?rio, este estudo demonstrou que o OEL/?CD reduziu a hiperalgesia prim?ria e secund?ria sem alterar a for?a muscular. Atribuiu estes efeitos ao poss?vel envolvimento de receptores opiod?rgicos e serotonin?rgicos, corroborando com a hip?tese de envolvimento da via descendente inibit?ria da dor, suportada por estudo in silico e pela express?o da proteina Fos no corno dorsal da medula, al?m da atividade antioxidante demonstrada pelo OEL e OEL/?CD. Ainda foi investigada a a??o antihiperalg?sica mec?nica e t?rmica do OEL e OEL/?CD (24mg/kg) em modelos de dor neurop?tica (liga??o parcial do nervo ci?tico) e de dor inflamat?ria persistente (CFA). A migra??o atenuada de leuc?citos associada aos n?veis reduzidos de TNF-? e IL-1? observados em modelo de pleurisia podem sugerir a redu??o de hiperalgesia e edema causados pela inje??o intraplantar de CFA observadas ap?s o tratamento oral com OEL e OEL/?CD. Este tratamento tamb?m reduziu o desenvolvimento de hiperalgesia mec?nica e t?rmica desencandeada pela liga??o parcial do nervo ci?tico. A redu??o dos n?veis de TNF-? no nervo ci?tico e na medula bem como de fosforila??o de NF?B e PKA nestas mesmos tecidos sugerem uma correla??o positiva entre a a??o do ?leo e a redu??o do efeito ?lgico destes mediadores. O OEL (24mg/kg) e OEL/?CD/ (24mg/kg) ainda inibiram a nocicep??o desencandeada pela inje??o plantar de cinamalde?do (agonista do TRPA1) e mentol (agonista do TRPM8). O tratamento oral agudo e prolongado com OEL e OEL-?CD (24 mg/kg) n?o alterou a atividade motora dos animais. Os resultados citados indicam que o OEL e o OEL/?CD (24mg/kg) podem ser potencialmente interessantes para o desenvolvimento de drogas clinicamente relevantes para o tratamento das desordens dolorosas cr?nicas.Submitted by Ricardo Cedraz Duque Moliterno (ricardo.moliterno@uefs.br) on 2019-02-11T23:19:30Z No. of bitstreams: 1 Tese Pollyana Vers?o Final-mesclado.pdf: 5871168 bytes, checksum: 47877c61a5c9bc62f1fea79dc30da458 (MD5)Made available in DSpace on 2019-02-11T23:19:30Z (GMT). No. of bitstreams: 1 Tese Pollyana Vers?o Final-mesclado.pdf: 5871168 bytes, checksum: 47877c61a5c9bc62f1fea79dc30da458 (MD5) Previous issue date: 2018-03-23Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfporUniversidade Estadual de Feira de SantanaDoutorado Acad?mico em BiotecnologiaUEFSBrasilDEPARTAMENTO DE CI?NCIAS BIOL?GICASDor cr?nicaDor n?o inflamat?riaDor neurop?tica?leo essencial?-ciclodextrinaLippia grataChronic painNon-inflammatory painNeuropathic painEssential oil?-cyclodextrinCIENCIAS BIOLOGICASEfeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?ticainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis-68152692297897915436006006006005026123383450589282-34391788430682021613590462550136975366info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UEFSinstname:Universidade Estadual de Feira de Santana (UEFS)instacron:UEFSORIGINALTese Pollyana Vers?o Final-mesclado.pdfTese Pollyana Vers?o Final-mesclado.pdfapplication/pdf5871168http://tede2.uefs.br:8080/bitstream/tede/721/2/Tese+Pollyana+Vers%C3%A3o+Final-mesclado.pdf47877c61a5c9bc62f1fea79dc30da458MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://tede2.uefs.br:8080/bitstream/tede/721/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51tede/7212019-02-12 21:11:48.883oai:tede2.uefs.br:8080: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.uefs.br:8080/PUBhttp://tede2.uefs.br:8080/oai/requestbcuefs@uefs.br|| bcref@uefs.br||bcuefs@uefs.bropendoar:2019-02-13T00:11:48Biblioteca Digital de Teses e Dissertações da UEFS - Universidade Estadual de Feira de Santana (UEFS)false |
dc.title.por.fl_str_mv |
Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica |
title |
Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica |
spellingShingle |
Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica Lima, Pollyana de Souza Siqueira Dor cr?nica Dor n?o inflamat?ria Dor neurop?tica ?leo essencial ?-ciclodextrina Lippia grata Chronic pain Non-inflammatory pain Neuropathic pain Essential oil ?-cyclodextrin CIENCIAS BIOLOGICAS |
title_short |
Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica |
title_full |
Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica |
title_fullStr |
Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica |
title_full_unstemmed |
Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica |
title_sort |
Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica |
author |
Lima, Pollyana de Souza Siqueira |
author_facet |
Lima, Pollyana de Souza Siqueira |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Lucchese, Ang?lica Maria |
dc.contributor.advisor1ID.fl_str_mv |
39684636091 |
dc.contributor.authorID.fl_str_mv |
95974423534 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0651476820928653 |
dc.contributor.author.fl_str_mv |
Lima, Pollyana de Souza Siqueira |
contributor_str_mv |
Lucchese, Ang?lica Maria |
dc.subject.por.fl_str_mv |
Dor cr?nica Dor n?o inflamat?ria Dor neurop?tica ?leo essencial ?-ciclodextrina Lippia grata |
topic |
Dor cr?nica Dor n?o inflamat?ria Dor neurop?tica ?leo essencial ?-ciclodextrina Lippia grata Chronic pain Non-inflammatory pain Neuropathic pain Essential oil ?-cyclodextrin CIENCIAS BIOLOGICAS |
dc.subject.eng.fl_str_mv |
Chronic pain Non-inflammatory pain Neuropathic pain Essential oil ?-cyclodextrin |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS |
description |
Chronic pain associated with non-inflammatory and neuropathic states is prevalent and debilitating, and still remains without an efficient and safe treatment. For this purpose, this study was designed to investigate the antihyperalgesic effect of free and complexed Lippia grata essential oil on ?-cyclodextrin (OEL/?CD) in animal models of chronic noninflammatory pain (fibromyalgia) and neuropathic pain. In this study, it was possible to demonstrate strong experimental evidence of how ?-cyclodextrin can act as a safe and low cost drug complexation system, improving the pharmacological properties of terpenes, transforming these natural products into an attractive choice for pharmacological use. In a systematic review, selecting the species of Lippia with properties on the central nervous system, this study observed that although several species present analgesic activity few studies have explored the mechanism of action responsible for these effects or have made a detailed phytochemical description or even investigated the toxicity and/or therapeutic safety of continued use of these drugs. Despite this, the results of the extracts and oils analyzes were consistent with most reports of ethnopharmacological studies reaffirming the importance of folk medicine as a guide for such studies. Using a non-inflammatory muscle pain model, this study demonstrated that OEL/?CD reduced primary and secondary hyperalgesia without altering muscle strength. It attributed these effects to the possible involvement of opiodergic and serotonergic receptors, corroborating the hypothesis of involvement of the pain inhibitory descending pathway supported by in silico study and the expression of the Fos protein in the dorsal horn of the medulla, in addition to the antioxidant activity demonstrated by OEL and OEL/?CD. The mechanical and thermal anti-hyperalgesic action of OEL and OEL/?CD (24mg / kg) in neuropathic pain (partial sciatic nerve ligation) and persistent inflammatory pain (CFA) models was also investigated. The attenuated migration of leukocytes associated with reduced levels of TNF-? and IL-1? observed in the pleurisy model may suggest the reduction of hyperalgesia and edema caused by the intraplantar injection of CFA observed after oral treatment with OEL and OEL/?CD. This treatment also reduced the development of mechanical and thermal hyperalgesia unleashed by the partial sciatic nerve ligation. Reduction of TNF-? levels in the sciatic nerve and medulla as well as phosphorylation of NF?B and PKA in these same tissues suggest a positive correlation between the action of the oil and the reduction of the algic effect of these mediators. The OEL (24mg/kg) and OEL/?CD (24mg/kg) did not inhibit the intraplantar injection-induced nociception of cinnamaldehyde (TRPA1 agonist) and menthol (TRPM8 agonist). The acute and prolonged oral treatment OEL and OEL-?CD (24 mg / kg) did not alter the motor activity of the animals. The results indicated that OEL/?CD (24mg/kg) may be potentially interesting for the development of drugs clinically relevant for the treatment of chronic pain disorders. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-03-23 |
dc.date.accessioned.fl_str_mv |
2019-02-11T23:19:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LIMA, Pollyana de Souza Siqueira. Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica. 2018. 188 f. Tese (Doutorado Acad?mico em Biotecnologia) - Universidade Estadual de Feira de Santana, Feira de Santana, 2018. |
dc.identifier.uri.fl_str_mv |
http://tede2.uefs.br:8080/handle/tede/721 |
identifier_str_mv |
LIMA, Pollyana de Souza Siqueira. Efeito anti-hiperalg?sico do ?leo essencial de Lippia grata livre e complexado em ?-ciclodextrina em modelos animais de dor cr?nica n?o inflamat?ria e dor neurop?tica. 2018. 188 f. Tese (Doutorado Acad?mico em Biotecnologia) - Universidade Estadual de Feira de Santana, Feira de Santana, 2018. |
url |
http://tede2.uefs.br:8080/handle/tede/721 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
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dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
5026123383450589282 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual de Feira de Santana |
dc.publisher.program.fl_str_mv |
Doutorado Acad?mico em Biotecnologia |
dc.publisher.initials.fl_str_mv |
UEFS |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
DEPARTAMENTO DE CI?NCIAS BIOL?GICAS |
publisher.none.fl_str_mv |
Universidade Estadual de Feira de Santana |
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reponame:Biblioteca Digital de Teses e Dissertações da UEFS instname:Universidade Estadual de Feira de Santana (UEFS) instacron:UEFS |
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Universidade Estadual de Feira de Santana (UEFS) |
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UEFS |
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UEFS |
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Biblioteca Digital de Teses e Dissertações da UEFS |
collection |
Biblioteca Digital de Teses e Dissertações da UEFS |
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http://tede2.uefs.br:8080/bitstream/tede/721/2/Tese+Pollyana+Vers%C3%A3o+Final-mesclado.pdf http://tede2.uefs.br:8080/bitstream/tede/721/1/license.txt |
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MD5 MD5 |
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Biblioteca Digital de Teses e Dissertações da UEFS - Universidade Estadual de Feira de Santana (UEFS) |
repository.mail.fl_str_mv |
bcuefs@uefs.br|| bcref@uefs.br||bcuefs@uefs.br |
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