Síntese de heteroarilazóis trialometilsubstituídos a partir de 2-acetilfurano e 2-acetiltiofeno
Ano de defesa: | 2004 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Química
|
País: |
BR
|
Palavras-chave em Português: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/4218 |
Resumo: | The synthesis of 1,1,1-trihalo-4-methoxy-4-[2-thienyl]-3-buten-2-ones, 1,1,1-trihalo-4-methoxy-4-[2-furyl]-3-buten-2-ones and the respective trihalomethyl 1,3-butanone derivatives by trihaloacylation of dimethoxy acetals derived from 2-acetylthiophene and 2-acetylfuran is reported. This is a convenient method to obtain fluorinated and chlorinated 1,3-dielectrophiles from 2-acetylthiophene and 2-acetylfuran. The halogenated 1,3-dielectrophiles were used to synthesize six new series of 2-thienyl- and 2-furylazoles. Heterocyclization of 1,1,1-trifluoro[trichloro]-4-methoxy-4-[2-tienyl]-3-buten-2-one and 1,1,1-trifluoro[trichloro]-4-methoxy-4-[2-furyl]-3-buten-2-ones in to isoxazoles and pyrazoles derivatives as a new type of trihalomethylated bicyclic heterocycles is reported. The structure of all products were assigned by 1H and 13C NMR and mass spectrometry. |
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Biblioteca Digital de Teses e Dissertações do UFSM |
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2017-05-252017-05-252004-04-07BRONDANI, Sergio. Synthesis of heteroarilazoles trihalomethylsubstituted from 2-acetylfuran and 2-acetylthiofen. 2004. 267 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2004.http://repositorio.ufsm.br/handle/1/4218The synthesis of 1,1,1-trihalo-4-methoxy-4-[2-thienyl]-3-buten-2-ones, 1,1,1-trihalo-4-methoxy-4-[2-furyl]-3-buten-2-ones and the respective trihalomethyl 1,3-butanone derivatives by trihaloacylation of dimethoxy acetals derived from 2-acetylthiophene and 2-acetylfuran is reported. This is a convenient method to obtain fluorinated and chlorinated 1,3-dielectrophiles from 2-acetylthiophene and 2-acetylfuran. The halogenated 1,3-dielectrophiles were used to synthesize six new series of 2-thienyl- and 2-furylazoles. Heterocyclization of 1,1,1-trifluoro[trichloro]-4-methoxy-4-[2-tienyl]-3-buten-2-one and 1,1,1-trifluoro[trichloro]-4-methoxy-4-[2-furyl]-3-buten-2-ones in to isoxazoles and pyrazoles derivatives as a new type of trihalomethylated bicyclic heterocycles is reported. The structure of all products were assigned by 1H and 13C NMR and mass spectrometry.Este trabalho, apresenta a síntese de 1,1,1-trialo-4-metoxi-4-[2-tienil]-3-buten-2-ona, 1,1,1-trialo-4-metoxi-4-[2-furil]-3-buten-2-ona e os respectivos derivados através de acilação dos dimetóxiacetais dos 2-acetilfurano ou 2-acetiltiofeno com agentes acilantes halogenados. Este é um método elegante, para a obtenção de 1,3-dieletrófilos fluorados ou clorados a partir do 2-acetilfurano e 2-acetiltiofeno. Os 1,3-dieletrófilos obtidos, foram usados na síntese de seis novas séries de 2-furanil e 2-tienil azóis. As reações de ciclocondensação das 1,1,1-trialo-4-metoxi-4-[2-heteroaril]-3-buten-2-ona e dos respectivos dicarbonílicos, até os isoxazóis e pirazóis, levam a formação de novas estruturas de bisheterociclos trialometil substituídos. A estrutura de todos os produtos isolados foi atribuida por RMN 1H e 13C e por espectrometria de massas.Conselho Nacional de Desenvolvimento Científico e Tecnológicoapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em QuímicaUFSMBRQuímicaQuímica orgânicaSíntese químicaIsoxazoisPirazoisCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICASíntese de heteroarilazóis trialometilsubstituídos a partir de 2-acetilfurano e 2-acetiltiofenoSynthesis of heteroarilazoles trihalomethylsubstituted from 2-acetylfuran and 2-acetylthiofeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisMartins, Marcos Antonio Pintohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783192P3Bonacorso, Helio Gauzehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4788537E0Zanatta, Nilohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783100P9http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4790234Y1Brondani, Sergio100600000000400300300300300c28419d9-6027-4f9c-acd2-76e8067a85d16e550244-3786-4fb7-bf9f-0e1817d25ebfdbcce58b-96b0-4f45-a78d-ca6f339e038d2f7bd6ce-78fa-4968-ac66-2d1407e90f60info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALSERGIO BRONDANI1.pdfapplication/pdf1378767http://repositorio.ufsm.br/bitstream/1/4218/1/SERGIO%20BRONDANI1.pdf8099e70560c89cb271d5cfb81be330dfMD51SERGIO BRONDANI2.pdfSERGIO BRONDANI2.pdfapplication/pdf1402511http://repositorio.ufsm.br/bitstream/1/4218/4/SERGIO%20BRONDANI2.pdfb9ad6b163440f2d1aea1bd1fcf32b8c2MD54SERGIO BRONDANI3.pdfSERGIO BRONDANI3.pdfapplication/pdf1526650http://repositorio.ufsm.br/bitstream/1/4218/5/SERGIO%20BRONDANI3.pdf6a1848059faa3294742abbb35a41258aMD55SERGIO BRONDANI4.pdfSERGIO BRONDANI4.pdfapplication/pdf1680240http://repositorio.ufsm.br/bitstream/1/4218/6/SERGIO%20BRONDANI4.pdf5fb1edbc00b29ff57736a0c6e6af2fffMD56SERGIO BRONDANI5.pdfSERGIO BRONDANI5.pdfapplication/pdf811661http://repositorio.ufsm.br/bitstream/1/4218/7/SERGIO%20BRONDANI5.pdfc0d99523e8d6913295a0abe4b3bd3940MD57SERGIO BRONDANI6.pdfSERGIO BRONDANI6.pdfapplication/pdf1269610http://repositorio.ufsm.br/bitstream/1/4218/8/SERGIO%20BRONDANI6.pdfc5ee05a6cf5e436f878d5fc7316432ebMD58TEXTSERGIO BRONDANI1.pdf.txtSERGIO BRONDANI1.pdf.txtExtracted texttext/plain149102http://repositorio.ufsm.br/bitstream/1/4218/2/SERGIO%20BRONDANI1.pdf.txt9d63a97b18ab5aea17faeaa48cd7f7c9MD52SERGIO BRONDANI2.pdf.txtSERGIO BRONDANI2.pdf.txtExtracted texttext/plain6146http://repositorio.ufsm.br/bitstream/1/4218/9/SERGIO%20BRONDANI2.pdf.txt8d74f9a28336f272f3442bd55741b740MD59SERGIO BRONDANI3.pdf.txtSERGIO BRONDANI3.pdf.txtExtracted texttext/plain6642http://repositorio.ufsm.br/bitstream/1/4218/11/SERGIO%20BRONDANI3.pdf.txt4b83c4da835c92290ed02c308e88e08cMD511SERGIO BRONDANI4.pdf.txtSERGIO BRONDANI4.pdf.txtExtracted texttext/plain5999http://repositorio.ufsm.br/bitstream/1/4218/13/SERGIO%20BRONDANI4.pdf.txt23f9034d58e5695c5280778b9cd73f16MD513SERGIO BRONDANI5.pdf.txtSERGIO BRONDANI5.pdf.txtExtracted texttext/plain2725http://repositorio.ufsm.br/bitstream/1/4218/15/SERGIO%20BRONDANI5.pdf.txt3962f555b525888b7daf49ca30f04dabMD515SERGIO BRONDANI6.pdf.txtSERGIO BRONDANI6.pdf.txtExtracted texttext/plain2812http://repositorio.ufsm.br/bitstream/1/4218/17/SERGIO%20BRONDANI6.pdf.txt47241ea01e5b2e9d47e2ce02fb75b679MD517THUMBNAILSERGIO BRONDANI1.pdf.jpgSERGIO BRONDANI1.pdf.jpgIM Thumbnailimage/jpeg5468http://repositorio.ufsm.br/bitstream/1/4218/3/SERGIO%20BRONDANI1.pdf.jpgb92a28475b9a5963ae67cb97e7d1c914MD53SERGIO BRONDANI2.pdf.jpgSERGIO BRONDANI2.pdf.jpgIM Thumbnailimage/jpeg3037http://repositorio.ufsm.br/bitstream/1/4218/10/SERGIO%20BRONDANI2.pdf.jpg5722988e3208a35b0bdd5895c7ef2b16MD510SERGIO BRONDANI3.pdf.jpgSERGIO BRONDANI3.pdf.jpgIM Thumbnailimage/jpeg5178http://repositorio.ufsm.br/bitstream/1/4218/12/SERGIO%20BRONDANI3.pdf.jpgf79068bf908278d26bd73b06cf4e0754MD512SERGIO BRONDANI4.pdf.jpgSERGIO BRONDANI4.pdf.jpgIM Thumbnailimage/jpeg5011http://repositorio.ufsm.br/bitstream/1/4218/14/SERGIO%20BRONDANI4.pdf.jpg442113cb8f05ac340a4cb2a3c98fda38MD514SERGIO BRONDANI5.pdf.jpgSERGIO BRONDANI5.pdf.jpgIM Thumbnailimage/jpeg5591http://repositorio.ufsm.br/bitstream/1/4218/16/SERGIO%20BRONDANI5.pdf.jpgb4aba2faa95f11cec6c564461e92770fMD516SERGIO BRONDANI6.pdf.jpgSERGIO BRONDANI6.pdf.jpgIM Thumbnailimage/jpeg5393http://repositorio.ufsm.br/bitstream/1/4218/18/SERGIO%20BRONDANI6.pdf.jpg88a404a8bfdaae5492d0aa92a506a3bfMD5181/42182017-07-25 11:05:11.378oai:repositorio.ufsm.br:1/4218Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2017-07-25T14:05:11Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Síntese de heteroarilazóis trialometilsubstituídos a partir de 2-acetilfurano e 2-acetiltiofeno |
dc.title.alternative.eng.fl_str_mv |
Synthesis of heteroarilazoles trihalomethylsubstituted from 2-acetylfuran and 2-acetylthiofen |
title |
Síntese de heteroarilazóis trialometilsubstituídos a partir de 2-acetilfurano e 2-acetiltiofeno |
spellingShingle |
Síntese de heteroarilazóis trialometilsubstituídos a partir de 2-acetilfurano e 2-acetiltiofeno Brondani, Sergio Química orgânica Síntese química Isoxazois Pirazois CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Síntese de heteroarilazóis trialometilsubstituídos a partir de 2-acetilfurano e 2-acetiltiofeno |
title_full |
Síntese de heteroarilazóis trialometilsubstituídos a partir de 2-acetilfurano e 2-acetiltiofeno |
title_fullStr |
Síntese de heteroarilazóis trialometilsubstituídos a partir de 2-acetilfurano e 2-acetiltiofeno |
title_full_unstemmed |
Síntese de heteroarilazóis trialometilsubstituídos a partir de 2-acetilfurano e 2-acetiltiofeno |
title_sort |
Síntese de heteroarilazóis trialometilsubstituídos a partir de 2-acetilfurano e 2-acetiltiofeno |
author |
Brondani, Sergio |
author_facet |
Brondani, Sergio |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Martins, Marcos Antonio Pinto |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783192P3 |
dc.contributor.referee1.fl_str_mv |
Bonacorso, Helio Gauze |
dc.contributor.referee1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4788537E0 |
dc.contributor.referee2.fl_str_mv |
Zanatta, Nilo |
dc.contributor.referee2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783100P9 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4790234Y1 |
dc.contributor.author.fl_str_mv |
Brondani, Sergio |
contributor_str_mv |
Martins, Marcos Antonio Pinto Bonacorso, Helio Gauze Zanatta, Nilo |
dc.subject.por.fl_str_mv |
Química orgânica Síntese química Isoxazois Pirazois |
topic |
Química orgânica Síntese química Isoxazois Pirazois CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
The synthesis of 1,1,1-trihalo-4-methoxy-4-[2-thienyl]-3-buten-2-ones, 1,1,1-trihalo-4-methoxy-4-[2-furyl]-3-buten-2-ones and the respective trihalomethyl 1,3-butanone derivatives by trihaloacylation of dimethoxy acetals derived from 2-acetylthiophene and 2-acetylfuran is reported. This is a convenient method to obtain fluorinated and chlorinated 1,3-dielectrophiles from 2-acetylthiophene and 2-acetylfuran. The halogenated 1,3-dielectrophiles were used to synthesize six new series of 2-thienyl- and 2-furylazoles. Heterocyclization of 1,1,1-trifluoro[trichloro]-4-methoxy-4-[2-tienyl]-3-buten-2-one and 1,1,1-trifluoro[trichloro]-4-methoxy-4-[2-furyl]-3-buten-2-ones in to isoxazoles and pyrazoles derivatives as a new type of trihalomethylated bicyclic heterocycles is reported. The structure of all products were assigned by 1H and 13C NMR and mass spectrometry. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004-04-07 |
dc.date.accessioned.fl_str_mv |
2017-05-25 |
dc.date.available.fl_str_mv |
2017-05-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BRONDANI, Sergio. Synthesis of heteroarilazoles trihalomethylsubstituted from 2-acetylfuran and 2-acetylthiofen. 2004. 267 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2004. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/4218 |
identifier_str_mv |
BRONDANI, Sergio. Synthesis of heteroarilazoles trihalomethylsubstituted from 2-acetylfuran and 2-acetylthiofen. 2004. 267 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2004. |
url |
http://repositorio.ufsm.br/handle/1/4218 |
dc.language.iso.fl_str_mv |
por |
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por |
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100600000000 |
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400 300 300 300 300 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Química |
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UFSM |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Química |
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Universidade Federal de Santa Maria |
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