Impacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativo

• Ano de defesa: 2011
• Autor(a) principal: Paixão, Mírian Patrícia Castro Pereira
• Orientador(a): Bressan, Josefina
• Banca de defesa: Rosado, Eliane Lopes , Oliveira, Leandro Licursi de , Ribeiro, Sônia Machado Rocha
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Viçosa
• Programa de Pós-Graduação: Doutorado em Ciência e Tecnologia de Alimentos
• Departamento: Ciência de Alimentos; Tecnologia de Alimentos; Engenharia de Alimentos
• País: BR
• Palavras-chave em Português: Dieta dissociada; Estresse oxidativo; Obesidade
• Palavras-chave em Inglês: Diet dissociated; Oxidative stress; Obesity
• Área do conhecimento CNPq: CNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS::CIENCIA DE ALIMENTOS
• Link de acesso: http://locus.ufv.br/handle/123456789/463

Obesity is a chronic disease that contributes to the development of oxidative stress, increased risk of developing cardiovascular disease and metabolic syndrome. Alternatives for the treatment of obesity various types of low-calorie diets have been used, among these, the dissociated diet. This diet recommends that carbohydrate and protein should not be consumed in a meal together in order to promote greater efficiency and accelerate the metabolic process of weight reduction. The aim of this study was to investigate the effect of dietary carbohydrate and protein in dissociated diets on biomarkers of oxidative stress represented by circulating levels of oxidized low density lipoprotein (oxLDL) and plasma total antioxidant capacity (TAC) and their associations with anthropometric, biochemical, and dietary oxidative in men in conditions of overweight and obesity. The study included 31 healthy men with BMI between 26.5 and 35.2 kg/m2, who followed the diet for 8 weeks with caloric restriction the 250 kcal. The subjects were randomly divided into three groups according to the type of diet. For the control group (GCT), was prescribed a diet balanced in nutrients, the group of day-carbohydrate (GCD) was prescribed a high carbohydrate / low-protein lunch and dinner, while in the night- carbohydrate group (GCN) the distribution of macronutrients in the meals was the reverse of the GCD. At the beginning and end of this study were analyzed anthropometric measurements, body composition using the deuterium and the serum glucose, insulin, cholesterol and fractions, triglycerides, uric acid, ceruloplasmin, TAC and oxLDL. Diet composition and the overall quality of the usual diet and during the intervention were analyzed using food diaries and Dietary Quality Index- International (IDQI). At the end of eight weeks, the volunteers had an average weight loss of 4.26 ± 1.47% in GCT, 3.29 ± 2.46 in the GCD, and 4.85 ± 3.01% at GCN and there was a reduction in BMI, WC and HC in the significant when compared to the initial period. There were no differences between groups in the observed changes in anthropometric measurements. The average caloric restriction was 26.01 ± 22.03% in GCT, 31.70 ± 30.28% in the GCN and 16.87 ± 26.67% in the GCD and there was no difference between groups. The quality of the overall diet and nutritional composition showed no significant variations between groups, with the exception of sodium and selenium, which showed a greater reduction in BCM when compared to the other groups (p <0.05). According IDQI the diet of the volunteers was characterized as low quality both in the evaluation of habitual intake and during the intervention. The oxidative and biochemical variables analyzed have not changed significantly between the groups during the study with the exception of serum glucose rose in the GCD and HDL-C which is elevated and insulin decreased in the GCT group (p <0.05), but remained within the normal range. Despite dietary and endogenous variables that could influence serum concentrations of biomarkers of oxidative stress have not changed substantially, TAC rose at the GCT and GCD (p <0.05). While the serum concentration of oxLDL was higher in GCT compared to other groups (p <0.05) and its concentration decreased not significantly only in GCD (p> 0.05). There were no associations between variations in TAC and oxLDL and quantity supplied of carbohydrate or protein meals in there that the dissociation of the diet (p> 0.05). The same analysis was performed for IDQI and their partial scores with respect to TAC and oxLDL and no correlation was observed between these variables, even after adjustment (p> 0.05). We conclude that although the dissociated diet have promoted weight loss and reduction of other anthropometric variables, no relationship was observed between TAC and oxLDL with biochemical variables, and dietary oxidative studied.