Compostos de Pd(II) e Zn(II) derivados de N-R-sulfonilditiocarbimatos: Síntese, caracterização e avaliação da atividade antimicrobiana

• Ano de defesa: 2013
• Autor(a) principal: Oliveira, Alexandre Almeida
• Orientador(a): Oliveira, Marcelo Ribeiro Leite de
• Banca de defesa: Teixeira, Róbson Ricardo , Zambolim, Laércio
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Viçosa
• Programa de Pós-Graduação: Mestrado em Agroquímica
• Departamento: Agroquímica analítica; Agroquímica inorgânica e Físico-química; Agroquímica orgânica
• País: BR
• Palavras-chave em Português: Pd(II); Zn(II); N-R-sulfonilditiocarbimatos; Avaliação da atividade antimicrobiana
• Palavras-chave em Inglês: Pd(II); Zn(II); N-R-sulphonyldithiocarbimates; Evaluation of antimicrobial activity
• Área do conhecimento CNPq: CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA
• Link de acesso: http://locus.ufv.br/handle/123456789/2154

Aiming to increase the knowledge on the structure of complexes based on N-Rsulphonyldithiocarbimate ligands, in the present work are discussed the syntheses and characterization of seven new heteroleptic palladium(II) complexes [Pd(RSO2N=CS2)(PPh3)2] (R = C2H5, C4H9, C8H17, 4-FC6H4, 4-ClC6H4, 4-BrC6H4 and 4-IC6H4), four new salts of homoleptic palladium(II) complexes [PPh3R]2[Pd(4- FC6H4SO2N=CS2)2] (R = CH3, C2H5, C4H9, C6H5) and three new salts of homoleptic zinc(II) complexes [PPh3R]2[Zn(4-FC6H4SO2N=CS2)2] (R = CH3, C2H5, C4H9). The compounds were characterized by their melting points, elemental analyses, vibrational spectroscopy, eletronic spectroscopy, 1H, 13C and 31P NMR spectroscopy, as well as X ray diffraction. The data collected are in agreement with the proposed structures. The synthesized compounds, the parent potassium N-R-sulphonyldithiocarbimates and Rtriphenylphosphonium halides had their antimicrobial activities evaluated against Escherichia coli and Staphylococcus aureus. Except for the Pd(II) complexes, all compounds were active. The in vitro antifungal activity of the R-triphenylphosphonium bis(4-fluorophenylsulphonyldithiocarbimate)zincate(II) compounds was investigated against Botrytis cinerea. Some of the tested compounds presented IC50 values which were inferior to those observed for bis(dimethyldithiocarbimato)zinc(II), active ingredient with known action fungicide, thus indicating a great agrochemical potential of the new compounds. It was also verified that the nature of the R group in the Rtriphenylphosphonium cation influences the activity of the bis(4- fluorophenylsulphonyldithiocarbimate)zincate(II) salts, which decrease in the following sequence: PPh+4>C4H9PPh+3>C2H5PPH+3>CH3PPH+3 .