Análise histológica e histométrica do efeito do resveratrol em ratos submetidos a periodontite experimental
Ano de defesa: | 2017 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Positivo
Brasil Pós-Graduação Programa de Pós-Graduação em Odontologia Clínica UP |
Programa de Pós-Graduação: |
Não Informado pela instituição
|
Departamento: |
Não Informado pela instituição
|
País: |
Não Informado pela instituição
|
Palavras-chave em Português: | |
Link de acesso: | https://repositorio.cruzeirodosul.edu.br/handle/123456789/2060 |
Resumo: | This study aimed to evaluate the effect of RESV in rats submitted to experimental periodontitis. For development of periodontitis, ligatures were inserted into the right and left upper second molars of rats (Rattus norvegicus, albinus, Wistar) for 15 days. Then the animals (n = 32) were randomly assigned to 2 groups: Group Test (n = 16) ligation + RESV (RESV-β-CD) and Control Group (n = 16) ligation + β-CD. Both the Test Group and Control Group animals received the daily dose of 10 mg / mL / kg of RESV-β-CD or only β-CD according to the groups for 14 and 30 days. The animals were euthanized and the jaws separated, reduced and submitted to histological processing for histological and histometric analysis. Data were submitted to Student's t-test with significance level of 5%. The values of linear measurements in the interproximal region of the cementitious enamel junction (JEC) to the alveolar bone crest (COA) demonstrated that there was a lower bone resorption in the RESV-β-CD group 14 when compared to the β-CD14 group (p = 0.001). Between the experimental times it was verified that there was a statistical difference in the Test Group (p = 0.001), and the lowest bone loss measured from the JEC to the COA was verified in the time of 14 days. According to the methodology used, it can be concluded that RESV reduced resorption in the alveolar ridge crest region in 14 days, but the use of the drug in times longer than 30 days did not favor the reabsorption of the alveolar bone crest . |
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Análise histológica e histométrica do efeito do resveratrol em ratos submetidos a periodontite experimentalPeriodontitePolifenoisRatosReabsorção ósseaCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIAThis study aimed to evaluate the effect of RESV in rats submitted to experimental periodontitis. For development of periodontitis, ligatures were inserted into the right and left upper second molars of rats (Rattus norvegicus, albinus, Wistar) for 15 days. Then the animals (n = 32) were randomly assigned to 2 groups: Group Test (n = 16) ligation + RESV (RESV-β-CD) and Control Group (n = 16) ligation + β-CD. Both the Test Group and Control Group animals received the daily dose of 10 mg / mL / kg of RESV-β-CD or only β-CD according to the groups for 14 and 30 days. The animals were euthanized and the jaws separated, reduced and submitted to histological processing for histological and histometric analysis. Data were submitted to Student's t-test with significance level of 5%. The values of linear measurements in the interproximal region of the cementitious enamel junction (JEC) to the alveolar bone crest (COA) demonstrated that there was a lower bone resorption in the RESV-β-CD group 14 when compared to the β-CD14 group (p = 0.001). Between the experimental times it was verified that there was a statistical difference in the Test Group (p = 0.001), and the lowest bone loss measured from the JEC to the COA was verified in the time of 14 days. According to the methodology used, it can be concluded that RESV reduced resorption in the alveolar ridge crest region in 14 days, but the use of the drug in times longer than 30 days did not favor the reabsorption of the alveolar bone crest .Este estudo se propôs a avaliar o efeito do RESV em ratos submetidos a periodontite experimental. Para desenvolvimento da periodontite, foram inseridas ligaduras nos segundos molares superiores direito e esquerdo de ratos (Rattus norvegicus, albinus, Wistar) durante 15 dias. Em seguida os animais (n=32) foram alocados randomicamente em 2 grupos: Grupo Teste (n=16) ligadura + RESV (RESV-β-CD) e Grupo Controle (n=16) ligadura + β-CD. Tanto os animais do Grupo Teste como do Grupo Controle receberam a dose diária de 10 mg/mL/Kg de RESV-β-CD ou apenas β-CD de acordo com os grupos durante 14 e 30 dias. Os animais foram eutanasiados e as maxilas separadas, reduzidas e submetidas ao processamento histológico para análise histológica e histométrica. Os dados foram submetidos ao teste t de Student com nível de significância de 5%. Os valores das medidas lineares na região interproximal da Junção esmalte cemento (JEC) até a crista óssea alveolar (COA) demonstraram que houve uma menor reabsorção óssea no grupo RESV-β-CD 14, quando comparado com o grupo β-CD 14 (p=0,001). Entre os tempos experimentais foi verificado que houve diferença estatística no Grupo Teste (p=0,001), sendo que a menor perda óssea medida da JEC a COA foi verificada no tempo de 14 dias. De acordo com a metodologia utilizada, pode-se concluir que o RESV reduziu a reabsorção na região da crista óssea alveolar no tempo de 14 dias, mas o uso do fármaco em tempos longos como 30 dias, não favoreceu a reabsorção da crista óssea alveolar.Universidade PositivoBrasilPós-GraduaçãoPrograma de Pós-Graduação em Odontologia ClínicaUPStorrer, Carmen Lucia Muellerhttp://lattes.cnpq.br/5108563646697172Rigo Junior, Darlan2021-05-05T21:37:48Z20172021-05-05T21:37:48Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://repositorio.cruzeirodosul.edu.br/handle/123456789/2060porinfo:eu-repo/semantics/openAccessreponame:Repositório do Centro Universitário Braz Cubasinstname:Centro Universitário Braz Cubas (CUB)instacron:CUB2021-06-01T12:33:14Zoai:repositorio.cruzeirodosul.edu.br:123456789/2060Repositório InstitucionalPUBhttps://repositorio.brazcubas.edu.br/oai/requestbibli@brazcubas.edu.bropendoar:2021-06-01T12:33:14Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)false |
dc.title.none.fl_str_mv |
Análise histológica e histométrica do efeito do resveratrol em ratos submetidos a periodontite experimental |
title |
Análise histológica e histométrica do efeito do resveratrol em ratos submetidos a periodontite experimental |
spellingShingle |
Análise histológica e histométrica do efeito do resveratrol em ratos submetidos a periodontite experimental Rigo Junior, Darlan Periodontite Polifenois Ratos Reabsorção óssea CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Análise histológica e histométrica do efeito do resveratrol em ratos submetidos a periodontite experimental |
title_full |
Análise histológica e histométrica do efeito do resveratrol em ratos submetidos a periodontite experimental |
title_fullStr |
Análise histológica e histométrica do efeito do resveratrol em ratos submetidos a periodontite experimental |
title_full_unstemmed |
Análise histológica e histométrica do efeito do resveratrol em ratos submetidos a periodontite experimental |
title_sort |
Análise histológica e histométrica do efeito do resveratrol em ratos submetidos a periodontite experimental |
author |
Rigo Junior, Darlan |
author_facet |
Rigo Junior, Darlan |
author_role |
author |
dc.contributor.none.fl_str_mv |
Storrer, Carmen Lucia Mueller http://lattes.cnpq.br/5108563646697172 |
dc.contributor.author.fl_str_mv |
Rigo Junior, Darlan |
dc.subject.por.fl_str_mv |
Periodontite Polifenois Ratos Reabsorção óssea CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
topic |
Periodontite Polifenois Ratos Reabsorção óssea CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
This study aimed to evaluate the effect of RESV in rats submitted to experimental periodontitis. For development of periodontitis, ligatures were inserted into the right and left upper second molars of rats (Rattus norvegicus, albinus, Wistar) for 15 days. Then the animals (n = 32) were randomly assigned to 2 groups: Group Test (n = 16) ligation + RESV (RESV-β-CD) and Control Group (n = 16) ligation + β-CD. Both the Test Group and Control Group animals received the daily dose of 10 mg / mL / kg of RESV-β-CD or only β-CD according to the groups for 14 and 30 days. The animals were euthanized and the jaws separated, reduced and submitted to histological processing for histological and histometric analysis. Data were submitted to Student's t-test with significance level of 5%. The values of linear measurements in the interproximal region of the cementitious enamel junction (JEC) to the alveolar bone crest (COA) demonstrated that there was a lower bone resorption in the RESV-β-CD group 14 when compared to the β-CD14 group (p = 0.001). Between the experimental times it was verified that there was a statistical difference in the Test Group (p = 0.001), and the lowest bone loss measured from the JEC to the COA was verified in the time of 14 days. According to the methodology used, it can be concluded that RESV reduced resorption in the alveolar ridge crest region in 14 days, but the use of the drug in times longer than 30 days did not favor the reabsorption of the alveolar bone crest . |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017 2021-05-05T21:37:48Z 2021-05-05T21:37:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/2060 |
url |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/2060 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Positivo Brasil Pós-Graduação Programa de Pós-Graduação em Odontologia Clínica UP |
publisher.none.fl_str_mv |
Universidade Positivo Brasil Pós-Graduação Programa de Pós-Graduação em Odontologia Clínica UP |
dc.source.none.fl_str_mv |
reponame:Repositório do Centro Universitário Braz Cubas instname:Centro Universitário Braz Cubas (CUB) instacron:CUB |
instname_str |
Centro Universitário Braz Cubas (CUB) |
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CUB |
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CUB |
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Repositório do Centro Universitário Braz Cubas |
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Repositório do Centro Universitário Braz Cubas |
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Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB) |
repository.mail.fl_str_mv |
bibli@brazcubas.edu.br |
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