Efeitos da lesarterapia e terapia fotodinâmica no tratamento da doença periodontal em animais imunodeprimidos com tacrolimo

• Ano de defesa: 2012
• Autor(a) principal: Bottura Filho, Paulo Eduardo Ferraz
• Orientador(a): Baptista, Maria Alice Sperto Ferreira
• Banca de defesa: Lima, Emerson Quintino de , Borrasca, Albanir Gabriel
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Faculdade de Medicina de São José do Rio Preto
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências da Saúde
• Departamento: Medicina Interna; Medicina e Ciências Correlatas
• País: BR
• Palavras-chave em Português: tacrolimo; periodontite; terapia fotodinâmica; lasers
• Palavras-chave em Inglês: tacrolimus; periodontitis; photodynamic therapy; lasers
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
• Link de acesso: http://bdtd.famerp.br/handle/tede/161

Background: Periodontal disease is often associated with systemic diseases and is characterized by destruction of the tissues supporting the teeth. Patients using immunosuppressive drugs such as tacrolimus are among those who suffer from tissue destruction. Objective: To evaluate the effects of laser and photodynamic therapies (PDT) (nonsurgical) as an adjunct to scaling and root planing in the treatment of corona-induced periodontitis in rats immunosuppressed with tacrolimus (Prograf ®). Materials and methods: The animals were divided into five groups. Each groups had 6 rats. Group 1, the control group, received only saline solution throughout the study period of 42 days and did not receive periodontal treatment; Group 2, received saline solution and scaling and root planning (SRP); Group 3, received tacrolimus (1 mg/kg/day) and was treated with SRP; Group 4, animals were treated identically to group 3 and then administered laser treatment; and in Group 5, the animals were treated identically to group 3 and then administered photodynamic therapy. Results: Statistical analysis indicated decreased bone loss with the progression of time (p<0.005). There was no significant difference between the bone loss associated with the types of treatment administered to groups 1, 2 and 3 (p>0.9) and groups 4 and 5 (p>0.6). The analysis also indicated that immunosuppression was not a bone loss determining factor. Conclusion: Laser and PDT therapies were effective as an adjunctive treatment to SRP in reducing bone loss caused by experimental periodontitis induced in animals being treated systemically with tacrolimus.