O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos
| Ano de defesa: | 2015 |
|---|---|
| Autor(a) principal: |
Ribeiro, Jacira Souza
 |
| Orientador(a): | |
| Banca de defesa: | , , |
| Tipo de documento: | Dissertação |
| Tipo de acesso: | Acesso aberto |
| Idioma: | por |
| Instituição de defesa: |
Universidade Nove de Julho
|
| Programa de Pós-Graduação: |
Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o
|
| Departamento: |
Sa??de
|
| País: |
Brasil
|
| Palavras-chave em Português: | |
| Palavras-chave em Inglês: | |
| Área do conhecimento CNPq: | |
| Link de acesso: | http://bibliotecatede.uninove.br/handle/tede/1808 |
Resumo: | The low-intensity pulsed ultrasound (LIPUS) has been used to promote muscle repair with better quality and in shorter time, however, there is no standardization for the parameters used in clinical practice. Thus, the aim of this study was to evaluate the effect of USPBI on the repair of skeletal muscle of rats after cryoinjury. Male Wistar rats (n=45) were divided into 3 groups: control; only injury; Injured and treated with LIPUS. The LIPUS application was performed daily, using the stationary mode, pulse 1: 4, 1 MHz frequency, intensity 0.4 W / cm2 for 3 minutes. The injured groups were euthanized at 1, 2, 3 and 7 days following injury induction. The tibialis anterior muscle (TA) was removed for morphological analysis and collagen remodeling, and the muscle sections stained with H&E and Picrosirus Red, respectively. Then, the slides were photographed and quantified using the program "Image J". The analysis of MyoD and myogenin gene expression was performed using real time PCR. The results showed that the USPBI promoted modulation of inflammatory responses with a decrease of inflammatory infiltrates after 1, 2, 3 and 7 days, and reduction of myonecrosis after 7 days, followed by an increase in the number of immature fibers after 3 and 7 days, and increase of blood vessels on days 2, 3 and 7 days. Regarding the deposition of collagen, the results showed better organization of the fibers in all experimental periods, and increased deposition of collagen fibers in the injured group and treated after 2 and 3 days. In addition, treatment with LIPUS promoted increased gene expression of MyoD reduction after 3 days and after 7 days. Regarding myogenin expression, the treated group showed increased expression after 7 days. In conclusion, the LIPUS induced positive effects on muscle repair process leading to reduced inflammation and myonecrosis, increased in the immature fibers and mature blood vessels, as well as modulation of Myod and miogenin in different periods. |
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Ferrari, Raquel Agnelli MesquitaFerrari, Raquel Agnelli MesquitaFran??a, Cristiane MirandaDurigan, Rita de C??ssia Marquetihttp://lattes.cnpq.br/0805770517626532Ribeiro, Jacira Souza2018-06-19T15:19:00Z2015-12-10Ribeiro, Jacira Souza. O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos. 2015. 53 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1808The low-intensity pulsed ultrasound (LIPUS) has been used to promote muscle repair with better quality and in shorter time, however, there is no standardization for the parameters used in clinical practice. Thus, the aim of this study was to evaluate the effect of USPBI on the repair of skeletal muscle of rats after cryoinjury. Male Wistar rats (n=45) were divided into 3 groups: control; only injury; Injured and treated with LIPUS. The LIPUS application was performed daily, using the stationary mode, pulse 1: 4, 1 MHz frequency, intensity 0.4 W / cm2 for 3 minutes. The injured groups were euthanized at 1, 2, 3 and 7 days following injury induction. The tibialis anterior muscle (TA) was removed for morphological analysis and collagen remodeling, and the muscle sections stained with H&E and Picrosirus Red, respectively. Then, the slides were photographed and quantified using the program "Image J". The analysis of MyoD and myogenin gene expression was performed using real time PCR. The results showed that the USPBI promoted modulation of inflammatory responses with a decrease of inflammatory infiltrates after 1, 2, 3 and 7 days, and reduction of myonecrosis after 7 days, followed by an increase in the number of immature fibers after 3 and 7 days, and increase of blood vessels on days 2, 3 and 7 days. Regarding the deposition of collagen, the results showed better organization of the fibers in all experimental periods, and increased deposition of collagen fibers in the injured group and treated after 2 and 3 days. In addition, treatment with LIPUS promoted increased gene expression of MyoD reduction after 3 days and after 7 days. Regarding myogenin expression, the treated group showed increased expression after 7 days. In conclusion, the LIPUS induced positive effects on muscle repair process leading to reduced inflammation and myonecrosis, increased in the immature fibers and mature blood vessels, as well as modulation of Myod and miogenin in different periods.O ultrassom pulsado de baixa intensidade (USPBI) tem sido utilizado por promover um reparo muscular de melhor qualidade e menor dura????o, por??m, n??o h?? padroniza????o quanto aos par??metros utilizados na pr??tica cl??nica. O objetivo deste estudo foi avaliar o efeito do USPBI sobre o reparo do m??sculo esquel??tico de rato ap??s crioles??o. Foram utilizados 45 ratos Wistar, machos, divididos em 3 grupos experimentais: controle; somente les??o; lesionado tratado com USPBI. A aplica????o de USPBI foi realizada diariamente ap??s indu????o da les??o, modo estacion??rio, pulsado 1:4, frequ??ncia 1 MHz, intensidade 0,4 W/cm2, durante 3 minutos. Os grupos lesionados foram eutanasiados ap??s 1, 2, 3 e 7 dias da indu????o da les??o. O m??sculo tibial anterior (TA) foi removido para an??lise morfol??gica e de remodelamento do col??geno, sendo os cortes corados com H&E e Picrosirius Red, respectivamente. As l??minas foram fotografadas e quantificadas com aux??lio do programa ???Image J???. A express??o g??nica de MyoD e miogenina foi obtida por PCR em tempo real. Os resultados evidenciaram que o USPBI promoveu modula????o da resposta inflamat??ria, havendo redu????o do infiltrado inflamat??rio ap??s 1, 2, 3 e 7 dias, e redu????o da mionecrose ap??s 7 dias, seguido pelo aumento no n??mero de fibras imaturas ap??s 3 e 7 dias, e aumento dos vasos sangu??neos nos dias 2, 3 e 7 dias. Em rela????o ?? deposi????o de col??geno, os resultados evidenciaram melhor organiza????o das fibras em todos os per??odos experimentais, al??m de aumento da deposi????o de fibras col??genas no grupo lesionado e tratado ap??s 2 e 3 dias. Al??m disso, o tratamento com USPBI promoveu aumento da express??o g??nica de MyoD ap??s 3 dias e redu????o ap??s 7 dias. Em rela????o a express??o de miogenina, o grupo tratado demonstrou aumento da express??o ap??s 7 dias. Em conclus??o, o USPBI nos par??metros utilizados induziu efeitos positivos ao processo de reparo muscular causando redu????o do processo inflamat??rio e mionecrose, aumento de fibras jovens vasos sangu??neos maduros, al??m de modula????o de MyoD e miogenina nos diferentes per??odos avaliados.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-06-19T15:19:00Z No. of bitstreams: 1 Jacira Souza Ribeiro.pdf: 1136563 bytes, checksum: 6f35b1abf4cd3ca62f8560ee50069169 (MD5)Made available in DSpace on 2018-06-19T15:19:00Z (GMT). No. of bitstreams: 1 Jacira Souza Ribeiro.pdf: 1136563 bytes, checksum: 6f35b1abf4cd3ca62f8560ee50069169 (MD5) Previous issue date: 2015-12-10application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Ci??ncias da Reabilita????oUNINOVEBrasilSa??dereparo muscularultrassom pulsado de baixa intensidadecol??genoc??lulas sat??litesMyoDmiogeninamuscle repaircollagenlow-intensity pulsed ultrasoundsatellite cellsMyoDmyogeninCIENCIAS DA SAUDEO ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicosUltrasound pulsed low intensity in the regeneration of the previous tibial muscle of mouse: morphological analysis, organization and deposition of collagen and expression of regulatory myogenic factorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALJacira Souza Ribeiro.pdfJacira Souza Ribeiro.pdfapplication/pdf1136563http://localhost:8080/tede/bitstream/tede/1808/2/Jacira+Souza+Ribeiro.pdf6f35b1abf4cd3ca62f8560ee50069169MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/1808/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/18082018-06-19 12:19:00.23oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2018-06-19T15:19Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
| dc.title.por.fl_str_mv |
O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos |
| dc.title.alternative.eng.fl_str_mv |
Ultrasound pulsed low intensity in the regeneration of the previous tibial muscle of mouse: morphological analysis, organization and deposition of collagen and expression of regulatory myogenic factors |
| title |
O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos |
| spellingShingle |
O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos Ribeiro, Jacira Souza reparo muscular ultrassom pulsado de baixa intensidade col??geno c??lulas sat??lites MyoD miogenina muscle repair collagen low-intensity pulsed ultrasound satellite cells MyoD myogenin CIENCIAS DA SAUDE |
| title_short |
O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos |
| title_full |
O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos |
| title_fullStr |
O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos |
| title_full_unstemmed |
O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos |
| title_sort |
O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos |
| author |
Ribeiro, Jacira Souza |
| author_facet |
Ribeiro, Jacira Souza |
| author_role |
author |
| dc.contributor.advisor1.fl_str_mv |
Ferrari, Raquel Agnelli Mesquita |
| dc.contributor.referee1.fl_str_mv |
Ferrari, Raquel Agnelli Mesquita |
| dc.contributor.referee2.fl_str_mv |
Fran??a, Cristiane Miranda |
| dc.contributor.referee3.fl_str_mv |
Durigan, Rita de C??ssia Marqueti |
| dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0805770517626532 |
| dc.contributor.author.fl_str_mv |
Ribeiro, Jacira Souza |
| contributor_str_mv |
Ferrari, Raquel Agnelli Mesquita Ferrari, Raquel Agnelli Mesquita Fran??a, Cristiane Miranda Durigan, Rita de C??ssia Marqueti |
| dc.subject.por.fl_str_mv |
reparo muscular ultrassom pulsado de baixa intensidade col??geno c??lulas sat??lites MyoD miogenina |
| topic |
reparo muscular ultrassom pulsado de baixa intensidade col??geno c??lulas sat??lites MyoD miogenina muscle repair collagen low-intensity pulsed ultrasound satellite cells MyoD myogenin CIENCIAS DA SAUDE |
| dc.subject.eng.fl_str_mv |
muscle repair collagen low-intensity pulsed ultrasound satellite cells MyoD myogenin |
| dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
| description |
The low-intensity pulsed ultrasound (LIPUS) has been used to promote muscle repair with better quality and in shorter time, however, there is no standardization for the parameters used in clinical practice. Thus, the aim of this study was to evaluate the effect of USPBI on the repair of skeletal muscle of rats after cryoinjury. Male Wistar rats (n=45) were divided into 3 groups: control; only injury; Injured and treated with LIPUS. The LIPUS application was performed daily, using the stationary mode, pulse 1: 4, 1 MHz frequency, intensity 0.4 W / cm2 for 3 minutes. The injured groups were euthanized at 1, 2, 3 and 7 days following injury induction. The tibialis anterior muscle (TA) was removed for morphological analysis and collagen remodeling, and the muscle sections stained with H&E and Picrosirus Red, respectively. Then, the slides were photographed and quantified using the program "Image J". The analysis of MyoD and myogenin gene expression was performed using real time PCR. The results showed that the USPBI promoted modulation of inflammatory responses with a decrease of inflammatory infiltrates after 1, 2, 3 and 7 days, and reduction of myonecrosis after 7 days, followed by an increase in the number of immature fibers after 3 and 7 days, and increase of blood vessels on days 2, 3 and 7 days. Regarding the deposition of collagen, the results showed better organization of the fibers in all experimental periods, and increased deposition of collagen fibers in the injured group and treated after 2 and 3 days. In addition, treatment with LIPUS promoted increased gene expression of MyoD reduction after 3 days and after 7 days. Regarding myogenin expression, the treated group showed increased expression after 7 days. In conclusion, the LIPUS induced positive effects on muscle repair process leading to reduced inflammation and myonecrosis, increased in the immature fibers and mature blood vessels, as well as modulation of Myod and miogenin in different periods. |
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2015 |
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2015-12-10 |
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2018-06-19T15:19:00Z |
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Ribeiro, Jacira Souza. O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos. 2015. 53 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/1808 |
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Ribeiro, Jacira Souza. O ultrassom pulsado de baixa intensidade na regenera????o do m??sculo tibial anterior de rato: an??lise morfol??gica, organiza????o e deposi????o de col??geno e express??o de fatores regulat??rios miog??nicos. 2015. 53 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
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