Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar
Ano de defesa: | 2023 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Nove de Julho
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências da Reabilitação
|
Departamento: |
Saúde
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://bibliotecatede.uninove.br/handle/tede/3270 |
Resumo: | Introduction: Congenital heart defects account for nearly one-third of all major congenital anomalies. With advances in understanding, diagnosis and surgeries, there has been a significant increase in the survival of patients with congenital heart diseases. Among the long-term complications, PAH has considerable morbidity and mortality. Several clinical and laboratory markers are used to predict prognosis and survival, but the literature is not very robust in the pediatric population Objective: To analyze epidemiological data of patients with congenital heart disease and pulmonary arterial hypertension and to correlate functional capacity with pre-established markers in the literature of children and adolescents with congenital heart disease and pulmonary arterial hypertension. Methods: This is a retrospective study, with collection of anthropometric data, distance covered in the 6-minute walk test (meters), functional classification of the World Health Organization, BNP hormone and medications in use. Epidemiological variables were analyzed according to normality, in addition to the use of Spearman and Pearson correlation, when applicable. Results: The initial sample consisted of 59 patients, of which 34 were excluded for not meeting the inclusion criteria. The final sample consisted of 25 patients, of which 13 were female, with a mean age of 15.1 years (±1.25) and 12 were male, with a mean age of 16.5 years (±1. 75). The correlation between WHO-FC and 6MWT was r= 0.093, with p= 0.66 and the correlation between WHO-FC and BNP was r= 0.346, with p= 0.09. Conclusion: The present study did not found a significant correlation between functional capacity and biomarkers used for monitoring patients with PAH. |
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Jorge, Luciana Maria Malosa Sampaiohttp://lattes.cnpq.br/2970138065407046Sampaio, Luciana Maria Malosáhttp://lattes.cnpq.br/2970138065407046Costa, Ivan Pereshttp://lattes.cnpq.br/5306653964880919Palma, Renata Kelly dahttp://lattes.cnpq.br/2990647294511164http://lattes.cnpq.br/9278803551842523Oliveira, Mariana Carvalho de2023-12-06T17:04:02Z2023-06-28Oliveira, Mariana Carvalho de. Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar. 2023. 54 f. Dissertação( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/3270Introduction: Congenital heart defects account for nearly one-third of all major congenital anomalies. With advances in understanding, diagnosis and surgeries, there has been a significant increase in the survival of patients with congenital heart diseases. Among the long-term complications, PAH has considerable morbidity and mortality. Several clinical and laboratory markers are used to predict prognosis and survival, but the literature is not very robust in the pediatric population Objective: To analyze epidemiological data of patients with congenital heart disease and pulmonary arterial hypertension and to correlate functional capacity with pre-established markers in the literature of children and adolescents with congenital heart disease and pulmonary arterial hypertension. Methods: This is a retrospective study, with collection of anthropometric data, distance covered in the 6-minute walk test (meters), functional classification of the World Health Organization, BNP hormone and medications in use. Epidemiological variables were analyzed according to normality, in addition to the use of Spearman and Pearson correlation, when applicable. Results: The initial sample consisted of 59 patients, of which 34 were excluded for not meeting the inclusion criteria. The final sample consisted of 25 patients, of which 13 were female, with a mean age of 15.1 years (±1.25) and 12 were male, with a mean age of 16.5 years (±1. 75). The correlation between WHO-FC and 6MWT was r= 0.093, with p= 0.66 and the correlation between WHO-FC and BNP was r= 0.346, with p= 0.09. Conclusion: The present study did not found a significant correlation between functional capacity and biomarkers used for monitoring patients with PAH.Introdução: As cardiopatias congênitas representam quase um terço de todas as principais anomalias congênitas. Com o avanço na compreensão, diagnóstico e cirurgias, houve um aumento significativo na sobrevida dos portadores de cardiopatias congênitas. Dentre as complicações a longo prazo, a HAP tem considerável morbi-mortalidade. Diversos marcadores clínicos e laboratoriais são utilizados para prever o prognóstico e sobrevida, porém a literatura é pouco robusta na população pediátrica Objetivo: Analisar dados epidemiológicos de paciente com cardiopatias congênitas e hipertensão arterial pulmonar e correlacionar a capacidade funcional com marcadores pré-estabelecidos na literatura de crianças e adoslecentes com cardiopatias congênitas e hipertensão arterial pulmonar. Métodos: Trata-se de um estudo retrospectivo, com coleta de dados antropométricos, distância percorrida do teste de caminhada de 6 minutos (metros), classificação funcional da Organização Mundial de Saúde, hormônio BNP e medicações em uso. As variáveis epidemiológicas foram analisadas de acordo com a normalidade, além da utilização da correlação de Spearman e Pearson, quando aplicável. Resultados: A amostra inicial era composta por 59 pacientes, destes 34 foram excluídos por não preencherem os critérios de inclusão. A amostra final foi composta por 25 pacientes, sendo 13 pacientes do sexo feminino, com média de idade de 15,1 anos (±1,25) e 12 do sexo masculino, com média de idade de 16,5 anos (±1,75). A correlação entre a WHO-FC e TC6 foi de r= 0,093, com p= 0,66 e a correlação entre a WHO-FC e BNP foi de r= 0,346, com p= 0,09.Conclusão: O presente estudo não encontrou correlação significativa entre a capacidade funcional e biomarcadores utilizados para acompanhamento de pacientes com HAP.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2023-12-06T17:04:02Z No. of bitstreams: 1 Mariana Carvalho de Oliveira.pdf: 556911 bytes, checksum: 7e493adf8ccde7d7ef3660a8a31a0710 (MD5)Made available in DSpace on 2023-12-06T17:04:02Z (GMT). No. of bitstreams: 1 Mariana Carvalho de Oliveira.pdf: 556911 bytes, checksum: 7e493adf8ccde7d7ef3660a8a31a0710 (MD5) Previous issue date: 2023-06-28application/pdfporUniversidade Nove de JulhoPrograma de Pós-Graduação em Ciências da ReabilitaçãoUNINOVEBrasilSaúdecardiopatia congênitateste de caminhada de 6 minutoscapacidade funcionalcongenital heart disease6-minute walk testfunctional capacityCIENCIAS DA SAUDEAnálise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonarAnalysis of biomarkers and functional capacity in children and adolescents with pulmonary arterial hypertensioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALMariana Carvalho de Oliveira.pdfMariana Carvalho de Oliveira.pdfapplication/pdf556911http://localhost:8080/tede/bitstream/tede/3270/2/Mariana+Carvalho+de+Oliveira.pdf7e493adf8ccde7d7ef3660a8a31a0710MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/3270/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/32702023-12-06 14:22:55.714oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2023-12-06T17:22:55Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar |
dc.title.alternative.eng.fl_str_mv |
Analysis of biomarkers and functional capacity in children and adolescents with pulmonary arterial hypertension |
title |
Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar |
spellingShingle |
Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar Oliveira, Mariana Carvalho de cardiopatia congênita teste de caminhada de 6 minutos capacidade funcional congenital heart disease 6-minute walk test functional capacity CIENCIAS DA SAUDE |
title_short |
Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar |
title_full |
Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar |
title_fullStr |
Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar |
title_full_unstemmed |
Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar |
title_sort |
Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar |
author |
Oliveira, Mariana Carvalho de |
author_facet |
Oliveira, Mariana Carvalho de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Jorge, Luciana Maria Malosa Sampaio |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2970138065407046 |
dc.contributor.referee1.fl_str_mv |
Sampaio, Luciana Maria Malosá |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2970138065407046 |
dc.contributor.referee2.fl_str_mv |
Costa, Ivan Peres |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/5306653964880919 |
dc.contributor.referee3.fl_str_mv |
Palma, Renata Kelly da |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/2990647294511164 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9278803551842523 |
dc.contributor.author.fl_str_mv |
Oliveira, Mariana Carvalho de |
contributor_str_mv |
Jorge, Luciana Maria Malosa Sampaio Sampaio, Luciana Maria Malosá Costa, Ivan Peres Palma, Renata Kelly da |
dc.subject.por.fl_str_mv |
cardiopatia congênita teste de caminhada de 6 minutos capacidade funcional |
topic |
cardiopatia congênita teste de caminhada de 6 minutos capacidade funcional congenital heart disease 6-minute walk test functional capacity CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
congenital heart disease 6-minute walk test functional capacity |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Introduction: Congenital heart defects account for nearly one-third of all major congenital anomalies. With advances in understanding, diagnosis and surgeries, there has been a significant increase in the survival of patients with congenital heart diseases. Among the long-term complications, PAH has considerable morbidity and mortality. Several clinical and laboratory markers are used to predict prognosis and survival, but the literature is not very robust in the pediatric population Objective: To analyze epidemiological data of patients with congenital heart disease and pulmonary arterial hypertension and to correlate functional capacity with pre-established markers in the literature of children and adolescents with congenital heart disease and pulmonary arterial hypertension. Methods: This is a retrospective study, with collection of anthropometric data, distance covered in the 6-minute walk test (meters), functional classification of the World Health Organization, BNP hormone and medications in use. Epidemiological variables were analyzed according to normality, in addition to the use of Spearman and Pearson correlation, when applicable. Results: The initial sample consisted of 59 patients, of which 34 were excluded for not meeting the inclusion criteria. The final sample consisted of 25 patients, of which 13 were female, with a mean age of 15.1 years (±1.25) and 12 were male, with a mean age of 16.5 years (±1. 75). The correlation between WHO-FC and 6MWT was r= 0.093, with p= 0.66 and the correlation between WHO-FC and BNP was r= 0.346, with p= 0.09. Conclusion: The present study did not found a significant correlation between functional capacity and biomarkers used for monitoring patients with PAH. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-12-06T17:04:02Z |
dc.date.issued.fl_str_mv |
2023-06-28 |
dc.type.status.fl_str_mv |
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info:eu-repo/semantics/masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Oliveira, Mariana Carvalho de. Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar. 2023. 54 f. Dissertação( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/3270 |
identifier_str_mv |
Oliveira, Mariana Carvalho de. Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar. 2023. 54 f. Dissertação( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, São Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/3270 |
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por |
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por |
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Saúde |
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Universidade Nove de Julho |
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