Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa
Ano de defesa: | 2020 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Nove de Julho
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências da Reabilitação
|
Departamento: |
Saúde
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://bibliotecatede.uninove.br/handle/tede/2554 |
Resumo: | Introduction: Cardiovascular diseases are the main causes of mortality worldwide. Among the risk factors associated with these diseases, there is systemic arterial hypertension (HAS). HAS is considered the main cause of chronic kidney disease. In addition, the increase in blood pressure (BP) in postmenopausal women has been well documented. In this sense, it is also known that autonomic dysfunction, with increased blood pressure variability (VPA) and inflammation play important roles in the pathophysiology of HAS and its consequences on target organs such as the kidneys. On the other hand, pharmacological therapy with Enalapril and physical training have been clinically recommended for BP control. However, the association of these two types of therapies has been poorly studied, especially with regard to the impact on kidney damage in postmenopausal women. Objective: To investigate the effects of combined physical training (TFC) associated with treatment with Enalapril on VPA and on morphofunctional and inflammatory parameters in renal tissues in an experimental model of arterial hypertension and menopause. Methods: 32 spontaneously hypertensive rats (SHR) were used, distributed in 4 groups (n = 8 / group): sedentary oophorectomized (OS), sedentary oophorectomy treated with Enalapril (OSE), trained oophorectomy (OT) and trained oophorectomy treated with Enalapril (OTE). The oophorectomy was performed on the 1st day of the study and, after 5 days of pharmacological treatment and adaptation to the treadmill and training ladder, the OS group continued with placebo treatment for 8 weeks, while the other groups continued with treatment with antihypertensive medication ( 3mg / kg of Enalapril, diluted in drinking water) and / or TFC (3 days / week, 40-60% of the maximum capacity obtained in a treadmill and ladder stress test). At the end of 8 weeks, BP was recorded for VPA analysis and function analysis and inflammatory meters in renal tissue. Results: The OSE, OT and OTE groups showed a reduction in systolic BP (SBP) and diastolic BP (DBP) in relation to the OS group, while only the OT and OTE groups had lower SBP variance (VAR-SBP), standard deviation of SBP (DP-SBP) and SBP low frequency band (LF-PAS), in addition to an increase in the Alpha Index compared to the OS group. The combination of TFC and Enalapril resulted in additional benefits to the OTE group in VAR-PAS and Alpha Index. In renal assessments, there was a reduction in creatinine and IL-6 levels in the OSE, OT and OTE vs. OS, and only the OTE group showed increased creatinine clearance and IL-10 levels. The number of glomeruli was similar between the groups studied, but there was a reduction in severe interstitial tubule changes in OSE, OT and OTE vs. OS, with potentiated benefitial effect in trained groups (OT and OTE). Conclusion: TFC associated with drug therapy with Enalapril attenuated dysfunctions in vascular autonomic modulation and baroreflex sensitivity, which is probably associated with reduced inflammation and damage to renal tissue, impacting on improving renal function and reducing BP in a model hypertension and menopause. |
id |
NOVE_58af713286aa2f7b40c25cdbf6782614 |
---|---|
oai_identifier_str |
oai:localhost:tede/2554 |
network_acronym_str |
NOVE |
network_name_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
repository_id_str |
|
spelling |
Angelis, Kátia deAngelis, Kátia deFerrari, Raquel Agnelli MesquitaFarah, Vera de Moura Azevedohttp://lattes.cnpq.br/5347344015356510Silva, Michel Pablo dos Santos Ferreira2021-06-21T18:23:01Z2020-12-15Silva, Michel Pablo dos Santos Ferreira. Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa. 2020. 58 f. Dissertação( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2554Introduction: Cardiovascular diseases are the main causes of mortality worldwide. Among the risk factors associated with these diseases, there is systemic arterial hypertension (HAS). HAS is considered the main cause of chronic kidney disease. In addition, the increase in blood pressure (BP) in postmenopausal women has been well documented. In this sense, it is also known that autonomic dysfunction, with increased blood pressure variability (VPA) and inflammation play important roles in the pathophysiology of HAS and its consequences on target organs such as the kidneys. On the other hand, pharmacological therapy with Enalapril and physical training have been clinically recommended for BP control. However, the association of these two types of therapies has been poorly studied, especially with regard to the impact on kidney damage in postmenopausal women. Objective: To investigate the effects of combined physical training (TFC) associated with treatment with Enalapril on VPA and on morphofunctional and inflammatory parameters in renal tissues in an experimental model of arterial hypertension and menopause. Methods: 32 spontaneously hypertensive rats (SHR) were used, distributed in 4 groups (n = 8 / group): sedentary oophorectomized (OS), sedentary oophorectomy treated with Enalapril (OSE), trained oophorectomy (OT) and trained oophorectomy treated with Enalapril (OTE). The oophorectomy was performed on the 1st day of the study and, after 5 days of pharmacological treatment and adaptation to the treadmill and training ladder, the OS group continued with placebo treatment for 8 weeks, while the other groups continued with treatment with antihypertensive medication ( 3mg / kg of Enalapril, diluted in drinking water) and / or TFC (3 days / week, 40-60% of the maximum capacity obtained in a treadmill and ladder stress test). At the end of 8 weeks, BP was recorded for VPA analysis and function analysis and inflammatory meters in renal tissue. Results: The OSE, OT and OTE groups showed a reduction in systolic BP (SBP) and diastolic BP (DBP) in relation to the OS group, while only the OT and OTE groups had lower SBP variance (VAR-SBP), standard deviation of SBP (DP-SBP) and SBP low frequency band (LF-PAS), in addition to an increase in the Alpha Index compared to the OS group. The combination of TFC and Enalapril resulted in additional benefits to the OTE group in VAR-PAS and Alpha Index. In renal assessments, there was a reduction in creatinine and IL-6 levels in the OSE, OT and OTE vs. OS, and only the OTE group showed increased creatinine clearance and IL-10 levels. The number of glomeruli was similar between the groups studied, but there was a reduction in severe interstitial tubule changes in OSE, OT and OTE vs. OS, with potentiated benefitial effect in trained groups (OT and OTE). Conclusion: TFC associated with drug therapy with Enalapril attenuated dysfunctions in vascular autonomic modulation and baroreflex sensitivity, which is probably associated with reduced inflammation and damage to renal tissue, impacting on improving renal function and reducing BP in a model hypertension and menopause.Introdução: As doenças cardiovasculares são as principais causas de mortalidade em todo mundo. Dentre os fatores de risco associados à essas doenças, está a hipertensão arterial sistêmica (HAS). A HAS é considerada a principal causa de doença renal crônica. Somado a isso, o aumento da pressão arterial (PA) em mulheres na pós-menopausa tem sido bem documentado. Neste sentido, sabe-se também que a disfunção autonômica, com aumento da variabilidade da pressão arterial (VPA) e a inflamação exercem funções importantes na fisiopatologia da HAS e de suas consequências em órgãos-alvo como os rins. Por outro lado, a terapia farmacológica com Enalapril e o treinamento físico têm sido clinicamente recomendados para o controle da PA. No entanto, a associação destes dois tipos de terapias foi muito pouco estudada, principalmente no que se refere ao impacto sobre o dano renal em mulheres na pós-menopausa. Objetivo: Investigar os efeitos do treinamento físico combinado (TFC) associado ao tratamento com Enalapril sobre a VPA e em parâmetros morfofuncionais e inflamatórios em tecidos renais em um modelo experimental de hipertensão arterial e menopausa. Métodos: Foram utilizadas 32 ratas espontaneamente hipertensas (SHR), sendo distribuídas em 4 grupos (n=8/grupo): Ooforectomizadas sedentárias (OS), ooforectomizadas sedentárias tratadas com Enalapril (OSE), ooforectomizadas treinadas (OT) e ooforectomizadas treinadas tratadas com Enalapril (OTE). A ooforectomia foi realizada no 1º dia do estudo e, após 5 dias de tratamento farmacológico e adaptação à esteira e escada de treinamento, o grupo OS prosseguiu com tratamento placebo durante 8 semanas, enquanto que os demais grupos prosseguiram com tratamento com anti-hipertensivo (3mg/kg de Enalapril, diluídos na água de beber) e/ou TFC (3 dias/semana, 40-60% da capacidade máxima obtida em teste de esforço em esteira e escada). Ao final das 8 semanas, foi realizado o registro da PA para análise da VPA e análises de função e medidores inflamatórios em tecido renal. Resultados: Os grupos OSE, OT e OTE apresentaram redução de PA sistólica (PAS) e PA diastólica (PAD) em relação ao grupo OS, enquanto somente os grupos OT e OTE apresentaram menor variância da PAS (VAR-PAS), desvio padrão da PAS (DP-PAS) e banda de baixa frequência da PAS (LF-PAS), além de aumento do Índice Alfa em comparação ao grupo OS. A associação do TFC e Enalapril resultaram em potencialização dos benefícios no grupo OTE para a VAR-PAS e o Índice Alfa. Nas avaliações renais, houve redução dos níveis de creatinina e de IL-6 nos grupos OSE, OT e OTE vs. OS, e somente o grupo OTE apresentou aumento do clearance de creatinina e os níveis de IL-10. O número de glomérulos foi semelhante entre os grupos estudados, mas houve redução de alterações túbulo intersticial graves nos OSE, OT e OTE vs. OS, com efeito benéfico potencializado nos grupos treinados (OT e OTE). Conclusão: O TFC associado a terapia medicamentosa com Enalapril atenuou as disfunções na modulação autonômica vascular e na sensibilidade barorreflexa, o que provavelmente está associado à redução da inflamação e lesão em tecido renal, impactando em melhora da função renal e redução da PA em um modelo experimental de hipertensão e menopausa.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-06-21T18:23:01Z No. of bitstreams: 1 Michel Pablo dos Santos Ferreira Silva.pdf: 1788647 bytes, checksum: 40b65aa3549aac99dc302324ea2e99f9 (MD5)Made available in DSpace on 2021-06-21T18:23:01Z (GMT). No. of bitstreams: 1 Michel Pablo dos Santos Ferreira Silva.pdf: 1788647 bytes, checksum: 40b65aa3549aac99dc302324ea2e99f9 (MD5) Previous issue date: 2020-12-15application/pdfporUniversidade Nove de JulhoPrograma de Pós-Graduação em Ciências da ReabilitaçãoUNINOVEBrasilSaúdenefropatiahipertensão arterialpós-menopausaEnalapriltreinamento físico combinadoinflamaçãonephropathyhigh blood pressurepostmenopauseantihypertensive treatmentcombined physical traininginflammationCIENCIAS DA SAUDEImpacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausaImpact of combined phisical training (CPT) associated with treatment with Enalapril on blood pressure variability and renal dysfunction in an experimental model of arterial hypertension and menopauseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALMichel Pablo dos Santos Ferreira Silva.pdfMichel Pablo dos Santos Ferreira Silva.pdfapplication/pdf1788647http://localhost:8080/tede/bitstream/tede/2554/2/Michel+Pablo+dos+Santos+Ferreira+Silva.pdf40b65aa3549aac99dc302324ea2e99f9MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2554/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/25542021-06-21 15:23:01.311oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2021-06-21T18:23:01Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa |
dc.title.alternative.eng.fl_str_mv |
Impact of combined phisical training (CPT) associated with treatment with Enalapril on blood pressure variability and renal dysfunction in an experimental model of arterial hypertension and menopause |
title |
Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa |
spellingShingle |
Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa Silva, Michel Pablo dos Santos Ferreira nefropatia hipertensão arterial pós-menopausa Enalapril treinamento físico combinado inflamação nephropathy high blood pressure postmenopause antihypertensive treatment combined physical training inflammation CIENCIAS DA SAUDE |
title_short |
Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa |
title_full |
Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa |
title_fullStr |
Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa |
title_full_unstemmed |
Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa |
title_sort |
Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa |
author |
Silva, Michel Pablo dos Santos Ferreira |
author_facet |
Silva, Michel Pablo dos Santos Ferreira |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Angelis, Kátia de |
dc.contributor.referee1.fl_str_mv |
Angelis, Kátia de |
dc.contributor.referee2.fl_str_mv |
Ferrari, Raquel Agnelli Mesquita |
dc.contributor.referee3.fl_str_mv |
Farah, Vera de Moura Azevedo |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5347344015356510 |
dc.contributor.author.fl_str_mv |
Silva, Michel Pablo dos Santos Ferreira |
contributor_str_mv |
Angelis, Kátia de Angelis, Kátia de Ferrari, Raquel Agnelli Mesquita Farah, Vera de Moura Azevedo |
dc.subject.por.fl_str_mv |
nefropatia hipertensão arterial pós-menopausa Enalapril treinamento físico combinado inflamação |
topic |
nefropatia hipertensão arterial pós-menopausa Enalapril treinamento físico combinado inflamação nephropathy high blood pressure postmenopause antihypertensive treatment combined physical training inflammation CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
nephropathy high blood pressure postmenopause antihypertensive treatment combined physical training inflammation |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Introduction: Cardiovascular diseases are the main causes of mortality worldwide. Among the risk factors associated with these diseases, there is systemic arterial hypertension (HAS). HAS is considered the main cause of chronic kidney disease. In addition, the increase in blood pressure (BP) in postmenopausal women has been well documented. In this sense, it is also known that autonomic dysfunction, with increased blood pressure variability (VPA) and inflammation play important roles in the pathophysiology of HAS and its consequences on target organs such as the kidneys. On the other hand, pharmacological therapy with Enalapril and physical training have been clinically recommended for BP control. However, the association of these two types of therapies has been poorly studied, especially with regard to the impact on kidney damage in postmenopausal women. Objective: To investigate the effects of combined physical training (TFC) associated with treatment with Enalapril on VPA and on morphofunctional and inflammatory parameters in renal tissues in an experimental model of arterial hypertension and menopause. Methods: 32 spontaneously hypertensive rats (SHR) were used, distributed in 4 groups (n = 8 / group): sedentary oophorectomized (OS), sedentary oophorectomy treated with Enalapril (OSE), trained oophorectomy (OT) and trained oophorectomy treated with Enalapril (OTE). The oophorectomy was performed on the 1st day of the study and, after 5 days of pharmacological treatment and adaptation to the treadmill and training ladder, the OS group continued with placebo treatment for 8 weeks, while the other groups continued with treatment with antihypertensive medication ( 3mg / kg of Enalapril, diluted in drinking water) and / or TFC (3 days / week, 40-60% of the maximum capacity obtained in a treadmill and ladder stress test). At the end of 8 weeks, BP was recorded for VPA analysis and function analysis and inflammatory meters in renal tissue. Results: The OSE, OT and OTE groups showed a reduction in systolic BP (SBP) and diastolic BP (DBP) in relation to the OS group, while only the OT and OTE groups had lower SBP variance (VAR-SBP), standard deviation of SBP (DP-SBP) and SBP low frequency band (LF-PAS), in addition to an increase in the Alpha Index compared to the OS group. The combination of TFC and Enalapril resulted in additional benefits to the OTE group in VAR-PAS and Alpha Index. In renal assessments, there was a reduction in creatinine and IL-6 levels in the OSE, OT and OTE vs. OS, and only the OTE group showed increased creatinine clearance and IL-10 levels. The number of glomeruli was similar between the groups studied, but there was a reduction in severe interstitial tubule changes in OSE, OT and OTE vs. OS, with potentiated benefitial effect in trained groups (OT and OTE). Conclusion: TFC associated with drug therapy with Enalapril attenuated dysfunctions in vascular autonomic modulation and baroreflex sensitivity, which is probably associated with reduced inflammation and damage to renal tissue, impacting on improving renal function and reducing BP in a model hypertension and menopause. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-12-15 |
dc.date.accessioned.fl_str_mv |
2021-06-21T18:23:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Silva, Michel Pablo dos Santos Ferreira. Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa. 2020. 58 f. Dissertação( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2554 |
identifier_str_mv |
Silva, Michel Pablo dos Santos Ferreira. Impacto do treinamento físico combinado (TFC) associado ao tratamento com Enalapril na variabilidade da pressão arterial e na disfunção renal em um modelo experimental de hipertensão arterial e menopausa. 2020. 58 f. Dissertação( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, São Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/2554 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
8765449414823306929 |
dc.relation.confidence.fl_str_mv |
600 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências da Reabilitação |
dc.publisher.initials.fl_str_mv |
UNINOVE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Saúde |
publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da Uninove instname:Universidade Nove de Julho (UNINOVE) instacron:UNINOVE |
instname_str |
Universidade Nove de Julho (UNINOVE) |
instacron_str |
UNINOVE |
institution |
UNINOVE |
reponame_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
collection |
Biblioteca Digital de Teses e Dissertações da Uninove |
bitstream.url.fl_str_mv |
http://localhost:8080/tede/bitstream/tede/2554/2/Michel+Pablo+dos+Santos+Ferreira+Silva.pdf http://localhost:8080/tede/bitstream/tede/2554/1/license.txt |
bitstream.checksum.fl_str_mv |
40b65aa3549aac99dc302324ea2e99f9 bd3efa91386c1718a7f26a329fdcb468 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE) |
repository.mail.fl_str_mv |
bibliotecatede@uninove.br||bibliotecatede@uninove.br |
_version_ |
1797250763314954240 |