Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda
Ano de defesa: | 2016 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Nove de Julho
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde
|
Departamento: |
Saúde
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://bibliotecatede.uninove.br/handle/tede/2856 |
Resumo: | Asthma and periodontal disease (PD) present high prevalence and a high economic and social cost. Evidence suggests PD can exert systemic immunomodulatory effects. As the standard periodontal (PT) treatment for PD may not completely eliminate periodontal pathogens, photodynamic therapy (PDT), have been used with promising results. Therefore, the objective of this study was to evaluate whether PT associated with PDT is able to modulate pulmonary inflammation in an experimental model of acute asthma. Seventy- two male Balb/c mice (~ 2 months) were divided into 8 groups (n = 9): (1) basal- sham; (2) with PD; (3) with PD+PT; (4) with PD+PT+PDT, (5) Asthma, (6) A+PD (7) A+PD+PT (8) A+PD+PT+PDT. PD was induced by ligature technique (15 days) and asthma by administration of ovalbumin (OVA) and aluminum hydroxide subcutaneously (days 0 and 7) and nebulization with OVA (3x / week, for 2 weeks). PT was performed with mini-five curettes and PDT with methylene blue (0.005%) with λ = 660 nm, energy density 6.369 J/cm², 9J per point at 2 points. After 21 days, the animals were euthanized for morphological analysis of the lung and the mandible. The cytokines IL-4, IL-5, IL-10, IFN-γ TNF-α, IL-1β and IL-6 and mucus production were evaluated. Total and differential cell counts were performed on LBA and serum. The frequency of inflammatory cells was evaluated by flow cytometry. PD increased the amount of alkaline phosphatase and bone resorption (p<0.05). Asthma group and PD group induced an increase in the total amount of cells (p <0.05) in BAL. However, in the Asthma+PD group there was a decrease in these cells, except for the Asthma+PD+PT+PDT group (p<0.05). The Asthma group induced increase of Th2 profile cytokines and the DP group presented a Th1/Th2 mixed cytokine profile. There was a increased mucus production for Asthma, PD and Asthma+PD+PT+PDT. It is concluded that PD can cause pulmonary inflammation per se. The association of Asthma with PD improves the parameters of pulmonary inflammation. After treatment with PDT, pulmonary inflammation in the asthmatic mice returned near to the baseline asmatic values. |
id |
NOVE_b04b3662cdc98fa89062e21ae5b9335b |
---|---|
oai_identifier_str |
oai:localhost:tede/2856 |
network_acronym_str |
NOVE |
network_name_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
repository_id_str |
|
spelling |
Horliana, Anna Carolina Ratto TempestiniHorliana, Anna Carolina Ratto TempestiniFerrari, Raquel Agnelli MesquitaRenno, Ana Claudia Munizhttp://lattes.cnpq.br/8975383519113913Candeo, Larissa Carbonera2022-04-11T18:36:42Z2016-12-14Candeo, Larissa Carbonera. Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda. 2016. 113 f. Dissertação( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2856Asthma and periodontal disease (PD) present high prevalence and a high economic and social cost. Evidence suggests PD can exert systemic immunomodulatory effects. As the standard periodontal (PT) treatment for PD may not completely eliminate periodontal pathogens, photodynamic therapy (PDT), have been used with promising results. Therefore, the objective of this study was to evaluate whether PT associated with PDT is able to modulate pulmonary inflammation in an experimental model of acute asthma. Seventy- two male Balb/c mice (~ 2 months) were divided into 8 groups (n = 9): (1) basal- sham; (2) with PD; (3) with PD+PT; (4) with PD+PT+PDT, (5) Asthma, (6) A+PD (7) A+PD+PT (8) A+PD+PT+PDT. PD was induced by ligature technique (15 days) and asthma by administration of ovalbumin (OVA) and aluminum hydroxide subcutaneously (days 0 and 7) and nebulization with OVA (3x / week, for 2 weeks). PT was performed with mini-five curettes and PDT with methylene blue (0.005%) with λ = 660 nm, energy density 6.369 J/cm², 9J per point at 2 points. After 21 days, the animals were euthanized for morphological analysis of the lung and the mandible. The cytokines IL-4, IL-5, IL-10, IFN-γ TNF-α, IL-1β and IL-6 and mucus production were evaluated. Total and differential cell counts were performed on LBA and serum. The frequency of inflammatory cells was evaluated by flow cytometry. PD increased the amount of alkaline phosphatase and bone resorption (p<0.05). Asthma group and PD group induced an increase in the total amount of cells (p <0.05) in BAL. However, in the Asthma+PD group there was a decrease in these cells, except for the Asthma+PD+PT+PDT group (p<0.05). The Asthma group induced increase of Th2 profile cytokines and the DP group presented a Th1/Th2 mixed cytokine profile. There was a increased mucus production for Asthma, PD and Asthma+PD+PT+PDT. It is concluded that PD can cause pulmonary inflammation per se. The association of Asthma with PD improves the parameters of pulmonary inflammation. After treatment with PDT, pulmonary inflammation in the asthmatic mice returned near to the baseline asmatic values.A asma e a doença periodontal (DP) apresentam alta prevalência e um elevado custo econômico e social. Evidências sugerem que a DP pode exercer efeitos imunomoduladores sistêmicos. Como o tratamento periodontal (TP) padrão para DP pode não eliminar completamente os periodontopatógenos a terapia fotodinâmica (PDT), têm sido utilizada com resultados promissores. Portanto, o objetivo deste estudo foi avaliar se o TP associado à PDT é capaz de modular a inflamação pulmonar em modelo experimental de asma aguda. Setenta e dois camundongos Balb/c machos (~2 meses) foram divididos em 8 grupos (n=9): (1) Basal - não manipulados; (2) com DP; (3) com DP+TP; (4) com DP+TP+PDT, (5) Asma, (6) A+DP, (7) A+DP+TP, (8) A+DP+TP+PDT. A DP foi induzida pela técnica da ligadura (15 dias) e a asma pela administração de ovalbumina (OVA) e hidróxido de alunínio, via subcutânea (dias 0 e 7) e nebulização com OVA (3 x/semana, por 2 semanas). O TP foi realizado com curetas mini-five e a PDT com azul de metileno (0,005%), = 660 nm, densidade de energia 6.369 J/cm², 9J por ponto em 2 pontos. Após 21 dias os animais foram eutanasiados para análise morfológica do pulmão e da mandíbula. Foram avaliadas as citocinas IL-4, IL-5, IL-10, IFN-γ TNF-α, IL-1β e IL-6 e produção de muco. Foi realizada a contagem total e diferencial de células inflamatórias no LBA e do soro. A frequência de células inflamatórias foi avaliada por citometria de fluxo. A DP aumentou a quantidade de fosfatase alcalina e reabsorção óssea (p<0,05). O grupo Asma e e o grupo DP induziram aumento da quantidade total de células (p<0,05) no LBA. Entretanto no grupo Asma+DP houve diminuição dessas células, com exceção do grupo Asma +DP+TP+PDT (p<0,05). O grupo Asma induziu aumento das citocinas com perfil Th2 e o grupo DP apresentou um perfil misto Th1/Th2 de liberação de citocinas. Houve aumento da produção de muco para Asma, DP e Asma+PD+TP+PDT. Conclui-se que a DP pode provocar inflamação pulmonar per se. A associação da Asma com DP melhora os parâmetros de inflamação pulmonar. Após o tratamento com a PDT, a inflamação pulmonar nos camundongos asmaticos aumentou novamente, chegando próximo aos níveis basais.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2022-04-11T18:36:42Z No. of bitstreams: 1 Larissa Carbonera Candeo.pdf: 6737046 bytes, checksum: c45271e602be720477e746d3a2bbd011 (MD5)Made available in DSpace on 2022-04-11T18:36:42Z (GMT). No. of bitstreams: 1 Larissa Carbonera Candeo.pdf: 6737046 bytes, checksum: c45271e602be720477e746d3a2bbd011 (MD5) Previous issue date: 2016-12-14application/pdfporUniversidade Nove de JulhoPrograma de Pós-Graduação em Biofotônica Aplicada às Ciências da SaúdeUNINOVEBrasilSaúdeasmadoenças periodontaislasersterapia fotodinâmicaasthmaperiodontal diseaseslasersphotodynamic therapyCIENCIAS DA SAUDEAvaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma agudaEvaluation of periodontal treatment associated with photodynamic therapy in the modulation of pulmonary inflammation in an experimental model of acute asthmainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALLarissa Carbonera Candeo.pdfLarissa Carbonera Candeo.pdfapplication/pdf6737046http://localhost:8080/tede/bitstream/tede/2856/2/Larissa+Carbonera+Candeo.pdfc45271e602be720477e746d3a2bbd011MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2856/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/28562022-04-11 15:36:42.035oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2022-04-11T18:36:42Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda |
dc.title.alternative.eng.fl_str_mv |
Evaluation of periodontal treatment associated with photodynamic therapy in the modulation of pulmonary inflammation in an experimental model of acute asthma |
title |
Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda |
spellingShingle |
Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda Candeo, Larissa Carbonera asma doenças periodontais lasers terapia fotodinâmica asthma periodontal diseases lasers photodynamic therapy CIENCIAS DA SAUDE |
title_short |
Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda |
title_full |
Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda |
title_fullStr |
Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda |
title_full_unstemmed |
Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda |
title_sort |
Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda |
author |
Candeo, Larissa Carbonera |
author_facet |
Candeo, Larissa Carbonera |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Horliana, Anna Carolina Ratto Tempestini |
dc.contributor.referee1.fl_str_mv |
Horliana, Anna Carolina Ratto Tempestini |
dc.contributor.referee2.fl_str_mv |
Ferrari, Raquel Agnelli Mesquita |
dc.contributor.referee3.fl_str_mv |
Renno, Ana Claudia Muniz |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8975383519113913 |
dc.contributor.author.fl_str_mv |
Candeo, Larissa Carbonera |
contributor_str_mv |
Horliana, Anna Carolina Ratto Tempestini Horliana, Anna Carolina Ratto Tempestini Ferrari, Raquel Agnelli Mesquita Renno, Ana Claudia Muniz |
dc.subject.por.fl_str_mv |
asma doenças periodontais lasers terapia fotodinâmica |
topic |
asma doenças periodontais lasers terapia fotodinâmica asthma periodontal diseases lasers photodynamic therapy CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
asthma periodontal diseases lasers photodynamic therapy |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Asthma and periodontal disease (PD) present high prevalence and a high economic and social cost. Evidence suggests PD can exert systemic immunomodulatory effects. As the standard periodontal (PT) treatment for PD may not completely eliminate periodontal pathogens, photodynamic therapy (PDT), have been used with promising results. Therefore, the objective of this study was to evaluate whether PT associated with PDT is able to modulate pulmonary inflammation in an experimental model of acute asthma. Seventy- two male Balb/c mice (~ 2 months) were divided into 8 groups (n = 9): (1) basal- sham; (2) with PD; (3) with PD+PT; (4) with PD+PT+PDT, (5) Asthma, (6) A+PD (7) A+PD+PT (8) A+PD+PT+PDT. PD was induced by ligature technique (15 days) and asthma by administration of ovalbumin (OVA) and aluminum hydroxide subcutaneously (days 0 and 7) and nebulization with OVA (3x / week, for 2 weeks). PT was performed with mini-five curettes and PDT with methylene blue (0.005%) with λ = 660 nm, energy density 6.369 J/cm², 9J per point at 2 points. After 21 days, the animals were euthanized for morphological analysis of the lung and the mandible. The cytokines IL-4, IL-5, IL-10, IFN-γ TNF-α, IL-1β and IL-6 and mucus production were evaluated. Total and differential cell counts were performed on LBA and serum. The frequency of inflammatory cells was evaluated by flow cytometry. PD increased the amount of alkaline phosphatase and bone resorption (p<0.05). Asthma group and PD group induced an increase in the total amount of cells (p <0.05) in BAL. However, in the Asthma+PD group there was a decrease in these cells, except for the Asthma+PD+PT+PDT group (p<0.05). The Asthma group induced increase of Th2 profile cytokines and the DP group presented a Th1/Th2 mixed cytokine profile. There was a increased mucus production for Asthma, PD and Asthma+PD+PT+PDT. It is concluded that PD can cause pulmonary inflammation per se. The association of Asthma with PD improves the parameters of pulmonary inflammation. After treatment with PDT, pulmonary inflammation in the asthmatic mice returned near to the baseline asmatic values. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-12-14 |
dc.date.accessioned.fl_str_mv |
2022-04-11T18:36:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Candeo, Larissa Carbonera. Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda. 2016. 113 f. Dissertação( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2856 |
identifier_str_mv |
Candeo, Larissa Carbonera. Avaliação do tratamento periodontal associado à terapia fotodinâmica na modulação da inflamação pulmonar em modelo experimental de asma aguda. 2016. 113 f. Dissertação( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/2856 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
8765449414823306929 |
dc.relation.confidence.fl_str_mv |
600 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde |
dc.publisher.initials.fl_str_mv |
UNINOVE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Saúde |
publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da Uninove instname:Universidade Nove de Julho (UNINOVE) instacron:UNINOVE |
instname_str |
Universidade Nove de Julho (UNINOVE) |
instacron_str |
UNINOVE |
institution |
UNINOVE |
reponame_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
collection |
Biblioteca Digital de Teses e Dissertações da Uninove |
bitstream.url.fl_str_mv |
http://localhost:8080/tede/bitstream/tede/2856/2/Larissa+Carbonera+Candeo.pdf http://localhost:8080/tede/bitstream/tede/2856/1/license.txt |
bitstream.checksum.fl_str_mv |
c45271e602be720477e746d3a2bbd011 bd3efa91386c1718a7f26a329fdcb468 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE) |
repository.mail.fl_str_mv |
bibliotecatede@uninove.br||bibliotecatede@uninove.br |
_version_ |
1797250766944075776 |