Ensaios moleculares para a verificação de alterações dos polimorfismos RS1801131 e RS1801133 do gene MTHFR em trabalhadores rurais no cultivo de cana-de-açúcar em exposição ocupacional a agrotóxicos

• Ano de defesa: 2023
• Autor(a) principal: Medeiros, Juliana Fernandes Venuzam
• Orientador(a): Cruz, Alex Silva da
• Banca de defesa: Santos, Felipe Corrêa Veloso dos , Gigonzac, Marc Alexandre Duarte
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica de Goiás
• Programa de Pós-Graduação: Programa de Pós-Graduação STRICTO SENSU em Genética
• Departamento: Escola de Ciências Médicas e da Vida
• País: Brasil
• Palavras-chave em Português: Agrotóxicos; Exposição ocupacional; Trabalhadores rurais; Saúde; Prevenção
• Palavras-chave em Inglês: Pesticides; Occupational exposure; Rural workers; Health; Prevention
• Área do conhecimento CNPq: CIÊNCIAS BIOLÓGICAS::GENÉTICA
• Link de acesso: https://tede2.pucgoias.edu.br/handle/tede/5235

Occupational exposure to pesticides in rural workers is a growing problem worldwide. In Brazil, one of the most affected sectors is the sugar cane/ethanol processing industry, where workers are frequently exposed to these chemicals. This exposure can have negative effects on the health of these workers, including the development of genomic alterations (CORRÊA et al., 2016). The study aimed to discover if rural workers who handle pesticides on a daily basis are at an increased risk due to occupational exposure to these chemicals. This was a case-control study where 207 participants were evaluated, 86 of whom were farmers exposed to pesticides directly and indirectly linked to sugar cane cultivation in the state of Goiás, forming the exposed group, and 121 individuals without a history of pesticide exposure but with similar socioeconomic conditions to rural workers. The participants come from 8 Goian municipalities, soy producers: Jataí, Rio Vede, and Gameleira. This study concluded that the use of pesticides in sugar cane cultivation is a concerning issue, as it can lead to serious health problems, including damage to the nervous system, cancer, and reproductive problems. Additionally, a significant proportion of the interviewed rural workers reported receiving hospital care after pesticide use. These data suggest possible pesticide intoxications and highlight the importance of implementing more effective safety measures to prevent exposure to these chemicals.