Formula??o de um cold kit otimizada para marca??o 99m Tc para diagn?stico de tumor neuroend?crino

Detalhes bibliográficos
Ano de defesa: 2015
Autor(a) principal: Fernandes, Bruna
Orientador(a): Santos, Marlise Ara?jo dos lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Pontif?cia Universidade Cat?lica do Rio Grande do Sul
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Biotecnologia Farmac?utica
Departamento: Faculdade de Farm?cia
País: Brasil
Palavras-chave em Português:
RADIOFARMAC?UTICA
QU?MICA NUCLEAR
NEOPLASIAS
NEUROENDOCRINOLOGIA
Área do conhecimento CNPq:
CIENCIAS DA SAUDE::FARMACIA
Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/6150
Resumo: Several companies wordwide produce kits with 99mTc labelling for diagnosing neuroendocrine tumors. Aiming at producing this kind of product in Brazil, a formulation was proposed, based on the methodology developed by Guggenberg et ul, using HYNIC-TOC, SnCl2, EDDA, tricine, mannitol and ascorbic acid. For labelling the cold kit, metastable radionuclide technetium (99mTc), produced by a 99Mo generator was used. The product was stored at temperatures of 0 to 8?C and at 25?C before labelling. After the product was labelled, it was kept at room temperature for up to 4 hours. The time of exposure was sufficient to observe the shelf life of the product for each storage method. Considering a radiochemical purity (RCP) of 80%, the product remained stable during the eight-month storage at 0 to 8?C before labelling and up to 4 hours after labelling. Therefore, the use of this product is possible in centers of nuclear medicine for a longer period during the day.
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spelling Santos, Marlise Ara?jo dos52886824020http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4782451A601614146055Fernandes, Bruna2015-06-18T13:18:31Z2015-03-26http://tede2.pucrs.br/tede2/handle/tede/6150Several companies wordwide produce kits with 99mTc labelling for diagnosing neuroendocrine tumors. Aiming at producing this kind of product in Brazil, a formulation was proposed, based on the methodology developed by Guggenberg et ul, using HYNIC-TOC, SnCl2, EDDA, tricine, mannitol and ascorbic acid. For labelling the cold kit, metastable radionuclide technetium (99mTc), produced by a 99Mo generator was used. The product was stored at temperatures of 0 to 8?C and at 25?C before labelling. After the product was labelled, it was kept at room temperature for up to 4 hours. The time of exposure was sufficient to observe the shelf life of the product for each storage method. Considering a radiochemical purity (RCP) of 80%, the product remained stable during the eight-month storage at 0 to 8?C before labelling and up to 4 hours after labelling. Therefore, the use of this product is possible in centers of nuclear medicine for a longer period during the day.No mundo, diversas empresas produzem kits para diagn?stico de tumores neuroend?crinos para marca??o com 99m Tc. Com a inten??o de nacionalizar esse tipo de produto no Brasil, uma formula??o foi proposta e baseada na metodologia desenvolvida por Guggemberg et al, utilizando HYNIC-TOC, SnCL2, EDDA, tricina, manitol e ?cido asc?rbico. Para marca??o do cold kit, foi utilizado o radionucl?deo tecn?cio metaest?vel(99m Tc), produzido por um gerador de 99Mo. O produto foi armazenado em temperaturasde 0 a 8?C e a 25?C antes da marca??o. Ap?s marca??o do produto, esse foi mantido em temperatura ambiente por at? quatro horas. O tempo de exposi??o foi suficiente para observar a vida do produto em cada m?todo de armazenamento. Considerando-se em limite de PRQ (pureza radioqu?mica) de 80%, o produto se mostrou est?vel durante os oito meses, quando armazenado entre 0 a 8?C antes da marca??o, e at? quatro horas p?s-marca??o. Sendo assim, poss?vel a utiliza??o desse produto, em centro de medicina nuclear, por per?odo mais longo durante o dia.Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2015-06-18T13:18:31Z No. of bitstreams: 1 470631 - Texto Parcial.pdf: 431429 bytes, checksum: b5055842a739822ab3818d061be0160a (MD5)Made available in DSpace on 2015-06-18T13:18:31Z (GMT). No. of bitstreams: 1 470631 - Texto Parcial.pdf: 431429 bytes, checksum: b5055842a739822ab3818d061be0160a (MD5) Previous issue date: 2015-03-26application/pdfhttp://tede2.pucrs.br:80/tede2/retrieve/163011/470631%20-%20Texto%20Parcial.pdf.jpgporPontif?cia Universidade Cat?lica do Rio Grande do SulPrograma de P?s-Gradua??o em Biotecnologia Farmac?uticaPUCRSBrasilFaculdade de Farm?ciaRADIOFARMAC?UTICAQU?MICA NUCLEARNEOPLASIASNEUROENDOCRINOLOGIACIENCIAS DA SAUDE::FARMACIAFormula??o de um cold kit otimizada para marca??o 99m Tc para diagn?stico de tumor neuroend?crinoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis2304961219518893267600600600-83806546368433781166997636413449754996info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAIL470631 - Texto Parcial.pdf.jpg470631 - Texto Parcial.pdf.jpgimage/jpeg3531http://tede2.pucrs.br/tede2/bitstream/tede/6150/3/470631+-+Texto+Parcial.pdf.jpg09451dee49e0fe99e164f44fe1570aaeMD53ORIGINAL470631 - Texto Parcial.pdf470631 - Texto Parcial.pdfapplication/pdf431429http://tede2.pucrs.br/tede2/bitstream/tede/6150/2/470631+-+Texto+Parcial.pdfb5055842a739822ab3818d061be0160aMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8610http://tede2.pucrs.br/tede2/bitstream/tede/6150/1/license.txt5a9d6006225b368ef605ba16b4f6d1beMD51tede/61502015-09-29 08:26:21.338oai:tede2.pucrs.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2015-09-29T11:26:21Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.por.fl_str_mv Formula??o de um cold kit otimizada para marca??o 99m Tc para diagn?stico de tumor neuroend?crino
title Formula??o de um cold kit otimizada para marca??o 99m Tc para diagn?stico de tumor neuroend?crino
spellingShingle Formula??o de um cold kit otimizada para marca??o 99m Tc para diagn?stico de tumor neuroend?crino
Fernandes, Bruna
RADIOFARMAC?UTICA
QU?MICA NUCLEAR
NEOPLASIAS
NEUROENDOCRINOLOGIA
CIENCIAS DA SAUDE::FARMACIA
title_short Formula??o de um cold kit otimizada para marca??o 99m Tc para diagn?stico de tumor neuroend?crino
title_full Formula??o de um cold kit otimizada para marca??o 99m Tc para diagn?stico de tumor neuroend?crino
title_fullStr Formula??o de um cold kit otimizada para marca??o 99m Tc para diagn?stico de tumor neuroend?crino
title_full_unstemmed Formula??o de um cold kit otimizada para marca??o 99m Tc para diagn?stico de tumor neuroend?crino
title_sort Formula??o de um cold kit otimizada para marca??o 99m Tc para diagn?stico de tumor neuroend?crino
author Fernandes, Bruna
author_facet Fernandes, Bruna
author_role author
dc.contributor.advisor1.fl_str_mv Santos, Marlise Ara?jo dos
dc.contributor.advisor1ID.fl_str_mv 52886824020
dc.contributor.advisor1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4782451A6
dc.contributor.authorID.fl_str_mv 01614146055
dc.contributor.author.fl_str_mv Fernandes, Bruna
contributor_str_mv Santos, Marlise Ara?jo dos
dc.subject.por.fl_str_mv RADIOFARMAC?UTICA
QU?MICA NUCLEAR
NEOPLASIAS
NEUROENDOCRINOLOGIA
topic RADIOFARMAC?UTICA
QU?MICA NUCLEAR
NEOPLASIAS
NEUROENDOCRINOLOGIA
CIENCIAS DA SAUDE::FARMACIA
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::FARMACIA
description Several companies wordwide produce kits with 99mTc labelling for diagnosing neuroendocrine tumors. Aiming at producing this kind of product in Brazil, a formulation was proposed, based on the methodology developed by Guggenberg et ul, using HYNIC-TOC, SnCl2, EDDA, tricine, mannitol and ascorbic acid. For labelling the cold kit, metastable radionuclide technetium (99mTc), produced by a 99Mo generator was used. The product was stored at temperatures of 0 to 8?C and at 25?C before labelling. After the product was labelled, it was kept at room temperature for up to 4 hours. The time of exposure was sufficient to observe the shelf life of the product for each storage method. Considering a radiochemical purity (RCP) of 80%, the product remained stable during the eight-month storage at 0 to 8?C before labelling and up to 4 hours after labelling. Therefore, the use of this product is possible in centers of nuclear medicine for a longer period during the day.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-06-18T13:18:31Z
dc.date.issued.fl_str_mv 2015-03-26
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dc.publisher.none.fl_str_mv Pontif?cia Universidade Cat?lica do Rio Grande do Sul
dc.publisher.program.fl_str_mv Programa de P?s-Gradua??o em Biotecnologia Farmac?utica
dc.publisher.initials.fl_str_mv PUCRS
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Faculdade de Farm?cia
publisher.none.fl_str_mv Pontif?cia Universidade Cat?lica do Rio Grande do Sul
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