Avalia??o in vitro do processo de libera??o de Tacrolimus em comp?sitos de PLGA e polipirrol

Detalhes bibliográficos
Ano de defesa: 2015
Autor(a) principal: Melo, Maiana Piovesan de lattes
Orientador(a): Basso, Nara Regina de Souza
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Pontif?cia Universidade Cat?lica do Rio Grande do Sul
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Biotecnologia Farmac?utica
Departamento: Faculdade de Farm?cia
País: Brasil
Palavras-chave em Português:
Área do conhecimento CNPq:
Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/6206
Resumo: The repair of injured peripheral nerves is one of the most difficult tasks in neurosurgery. Among the techniques used is distinguished using the artificial tube for nerve guidance during the regeneration process. The preparation of composites based on biodegradable polymers and conducting polymers related to growth factors, have been proposed as a promising approach for improving regeneration of injured peripheral nerves. However, it should be considered that during the regeneration process is necessary to have a control over the dosage and the time of release of the drug in question not to jeopardize the recovery process.In this work were based membranes prepared PLGA (lactic-co-glycolic poly-acid), polypyrrole (PPy) and Tacrolimus as a growth factor. Was reported as a factor of the process of degradation and the relationship between the composition of membrane PLGA / PPy / Tacrolimus with the release of the drug in the first days of incubation. It was found that membranes with higher PLGA thicker, resulting in a lower weight loss and delayed release of Tacrolimus. In this work PLGA membranes containing search polypyrrole nanofibers (PPy) and Tacrolimus, as a growth factor, were prepared by the solvent evaporation method. The process of degradation and drug release were assessed 28 days of incubation. It was observed that membranes with a higher concentration of PLGA.
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spelling Basso, Nara Regina de Souza430.221.890-87775.460.590-20http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4399366E4Melo, Maiana Piovesan de2015-07-07T13:31:06Z2015-03-25http://tede2.pucrs.br/tede2/handle/tede/6206The repair of injured peripheral nerves is one of the most difficult tasks in neurosurgery. Among the techniques used is distinguished using the artificial tube for nerve guidance during the regeneration process. The preparation of composites based on biodegradable polymers and conducting polymers related to growth factors, have been proposed as a promising approach for improving regeneration of injured peripheral nerves. However, it should be considered that during the regeneration process is necessary to have a control over the dosage and the time of release of the drug in question not to jeopardize the recovery process.In this work were based membranes prepared PLGA (lactic-co-glycolic poly-acid), polypyrrole (PPy) and Tacrolimus as a growth factor. Was reported as a factor of the process of degradation and the relationship between the composition of membrane PLGA / PPy / Tacrolimus with the release of the drug in the first days of incubation. It was found that membranes with higher PLGA thicker, resulting in a lower weight loss and delayed release of Tacrolimus. In this work PLGA membranes containing search polypyrrole nanofibers (PPy) and Tacrolimus, as a growth factor, were prepared by the solvent evaporation method. The process of degradation and drug release were assessed 28 days of incubation. It was observed that membranes with a higher concentration of PLGA.A repara??o de nervos perif?ricos lesionados ? uma das tarefas mais dif?ceis na neurocirurgia. Entre as t?cnicas utilizadas destaca-se a utiliza??o de tubos artificiais para orientar o nervo durante o processo de regenera??o. A prepara??o de comp?sitos baseados em pol?meros biodegrad?veis e pol?meros condutores, associados a fatores de crescimento, t?m sido proposta como uma abordagem promissora para melhorar a regenera??o de nervos perif?ricos lesionados. Por?m, deve ser considerado que durante o processo de regenera??o ? necess?rio ter um controle sobre a dosagem e o tempo de libera??o do f?rmaco em quest?o para n?o prejudicar o processo de recupera??o.Assim, neste trabalho foram preparadas membranas baseadas em PLGA (poli-?cido l?ctico-co-glic?lico), polipirrol (PPy) e Tacrolimus como fator de crescimento. Foi avaliado o processo de degrada??o e a rela??o entre a composi??o de membranas de PLGA/PPy/Tacrolimus com a libera??o do f?rmaco nos primeiros dias de incuba??o. Foi verificado que membrana com maior quantidade de PLGA, mais espessa, resultou numa menor perda massa e retardou a libera??o do tacrolimus. Neste trabalho de pesquisa membranas de PLGA contendo nanofibras de polipirrol (PPy) e Tacrolimus, como fator de crescimento, foram preparadas por meio da metodologia da evapora??o do solvente. O processo de degrada??o e a libera??o do f?rmaco foram avaliados durante 28 dias de incuba??o. Foi observado que membranas com uma maior concentra??o do PLGA.Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2015-07-07T13:31:06Z No. of bitstreams: 1 471664 - Texto Completo.pdf: 1025603 bytes, checksum: cc2bf12cfe7084c63f710f9fd2c36364 (MD5)Made available in DSpace on 2015-07-07T13:31:06Z (GMT). No. of bitstreams: 1 471664 - Texto Completo.pdf: 1025603 bytes, checksum: cc2bf12cfe7084c63f710f9fd2c36364 (MD5) Previous issue date: 2015-03-25application/pdfhttp://tede2.pucrs.br:80/tede2/retrieve/163186/471664%20-%20Texto%20Completo.pdf.jpgporPontif?cia Universidade Cat?lica do Rio Grande do SulPrograma de P?s-Gradua??o em Biotecnologia Farmac?uticaPUCRSBrasilFaculdade de Farm?ciaFARMACOLOGIAMEDICAMENTOSREGENERA??O NERVOSAPOL?MEROSMATERIAIS BIOCOMPAT?VEISCIENCIAS DA SAUDE::FARMACIAAvalia??o in vitro do processo de libera??o de Tacrolimus em comp?sitos de PLGA e polipirrolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis2304961219518893267600600600-83806546368433781166997636413449754996info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAIL471664 - Texto Completo.pdf.jpg471664 - Texto Completo.pdf.jpgimage/jpeg3552http://tede2.pucrs.br/tede2/bitstream/tede/6206/4/471664+-+Texto+Completo.pdf.jpg63605682b706e9c9a13d977c50d572a7MD54TEXT471664 - Texto Completo.pdf.txt471664 - Texto Completo.pdf.txttext/plain79149http://tede2.pucrs.br/tede2/bitstream/tede/6206/3/471664+-+Texto+Completo.pdf.txt2237acb952ab989c5cd9a12bc14c3681MD53ORIGINAL471664 - Texto Completo.pdf471664 - Texto Completo.pdfapplication/pdf1025603http://tede2.pucrs.br/tede2/bitstream/tede/6206/2/471664+-+Texto+Completo.pdfcc2bf12cfe7084c63f710f9fd2c36364MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8610http://tede2.pucrs.br/tede2/bitstream/tede/6206/1/license.txt5a9d6006225b368ef605ba16b4f6d1beMD51tede/62062015-09-29 08:30:04.82oai:tede2.pucrs.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2015-09-29T11:30:04Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.por.fl_str_mv Avalia??o in vitro do processo de libera??o de Tacrolimus em comp?sitos de PLGA e polipirrol
title Avalia??o in vitro do processo de libera??o de Tacrolimus em comp?sitos de PLGA e polipirrol
spellingShingle Avalia??o in vitro do processo de libera??o de Tacrolimus em comp?sitos de PLGA e polipirrol
Melo, Maiana Piovesan de
FARMACOLOGIA
MEDICAMENTOS
REGENERA??O NERVOSA
POL?MEROS
MATERIAIS BIOCOMPAT?VEIS
CIENCIAS DA SAUDE::FARMACIA
title_short Avalia??o in vitro do processo de libera??o de Tacrolimus em comp?sitos de PLGA e polipirrol
title_full Avalia??o in vitro do processo de libera??o de Tacrolimus em comp?sitos de PLGA e polipirrol
title_fullStr Avalia??o in vitro do processo de libera??o de Tacrolimus em comp?sitos de PLGA e polipirrol
title_full_unstemmed Avalia??o in vitro do processo de libera??o de Tacrolimus em comp?sitos de PLGA e polipirrol
title_sort Avalia??o in vitro do processo de libera??o de Tacrolimus em comp?sitos de PLGA e polipirrol
author Melo, Maiana Piovesan de
author_facet Melo, Maiana Piovesan de
author_role author
dc.contributor.advisor1.fl_str_mv Basso, Nara Regina de Souza
dc.contributor.advisor1ID.fl_str_mv 430.221.890-87
dc.contributor.authorID.fl_str_mv 775.460.590-20
dc.contributor.authorLattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4399366E4
dc.contributor.author.fl_str_mv Melo, Maiana Piovesan de
contributor_str_mv Basso, Nara Regina de Souza
dc.subject.por.fl_str_mv FARMACOLOGIA
MEDICAMENTOS
REGENERA??O NERVOSA
POL?MEROS
MATERIAIS BIOCOMPAT?VEIS
topic FARMACOLOGIA
MEDICAMENTOS
REGENERA??O NERVOSA
POL?MEROS
MATERIAIS BIOCOMPAT?VEIS
CIENCIAS DA SAUDE::FARMACIA
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::FARMACIA
description The repair of injured peripheral nerves is one of the most difficult tasks in neurosurgery. Among the techniques used is distinguished using the artificial tube for nerve guidance during the regeneration process. The preparation of composites based on biodegradable polymers and conducting polymers related to growth factors, have been proposed as a promising approach for improving regeneration of injured peripheral nerves. However, it should be considered that during the regeneration process is necessary to have a control over the dosage and the time of release of the drug in question not to jeopardize the recovery process.In this work were based membranes prepared PLGA (lactic-co-glycolic poly-acid), polypyrrole (PPy) and Tacrolimus as a growth factor. Was reported as a factor of the process of degradation and the relationship between the composition of membrane PLGA / PPy / Tacrolimus with the release of the drug in the first days of incubation. It was found that membranes with higher PLGA thicker, resulting in a lower weight loss and delayed release of Tacrolimus. In this work PLGA membranes containing search polypyrrole nanofibers (PPy) and Tacrolimus, as a growth factor, were prepared by the solvent evaporation method. The process of degradation and drug release were assessed 28 days of incubation. It was observed that membranes with a higher concentration of PLGA.
publishDate 2015
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dc.publisher.none.fl_str_mv Pontif?cia Universidade Cat?lica do Rio Grande do Sul
dc.publisher.program.fl_str_mv Programa de P?s-Gradua??o em Biotecnologia Farmac?utica
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dc.publisher.department.fl_str_mv Faculdade de Farm?cia
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