Avaliação da sobrevida e caracterização clinico-patológica de pacientes com melanoma metastático para o sistema nervoso central
Ano de defesa: | 2023 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Pontifícia Universidade Católica do Rio Grande do Sul
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Medicina e Ciências da Saúde
|
Departamento: |
Escola de Medicina
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | https://tede2.pucrs.br/tede2/handle/tede/11132 |
Resumo: | Brain metastases from melanoma are frequent and are associated with a poor prognosis. They are associated with 60-70% of deaths in patients with melanoma. It is estimated that approximately one third of patients with newly diagnosed metastatic melanoma have synchronous radial metastases. This retrospective cohort study includes patients treated at Hospital São Lucas da PUCRS, from 2007 to 2017 and aims to evaluate survival and describe the clinicopathological characteristics of these patients.. All patients treated at the oncology service with a diagnosis of metastatic melanoma were included. Of the total number of patients with melanoma treated at the HSL-PUCRS oncology outpatient clinic, 67 (12.3%) had brain metastases. Most patients were male (67.2%) and more than half were white (50.7%). At the first evaluation, 63.6% of the patients were younger than 60 years, most had no family history of melanoma (44.8%). When we observed the pathological characteristics of the patients included, patients with lymph node involvement predominated, totaling 44.9%, the presence of ulceration was observed in 64.3% of the cases, the peripheral margin was negative in 85.7% of the cases, the absence of microsatellites was observed in 76.2% of the cases, 49.3% of the patients had a Clark level 4 or 5. About 1/3 of the patients had nodular melanoma and the most frequent primary site was the back, making up 28.4% of the cases. In the study population, a median survival of 75.9 months was estimated, which is higher than that observed in the literature and which can be explained by the profile of the patients analyzed. |
id |
P_RS_faf79b968879aebecc5921836979ca95 |
---|---|
oai_identifier_str |
oai:tede2.pucrs.br:tede/11132 |
network_acronym_str |
P_RS |
network_name_str |
Biblioteca Digital de Teses e Dissertações da PUC_RS |
repository_id_str |
|
spelling |
Fay, André Poislhttp://lattes.cnpq.br/6858336633023217http://lattes.cnpq.br/7759618134806078Ferla, Matheus dos Santos2024-04-08T13:54:34Z2023-12-13https://tede2.pucrs.br/tede2/handle/tede/11132Brain metastases from melanoma are frequent and are associated with a poor prognosis. They are associated with 60-70% of deaths in patients with melanoma. It is estimated that approximately one third of patients with newly diagnosed metastatic melanoma have synchronous radial metastases. This retrospective cohort study includes patients treated at Hospital São Lucas da PUCRS, from 2007 to 2017 and aims to evaluate survival and describe the clinicopathological characteristics of these patients.. All patients treated at the oncology service with a diagnosis of metastatic melanoma were included. Of the total number of patients with melanoma treated at the HSL-PUCRS oncology outpatient clinic, 67 (12.3%) had brain metastases. Most patients were male (67.2%) and more than half were white (50.7%). At the first evaluation, 63.6% of the patients were younger than 60 years, most had no family history of melanoma (44.8%). When we observed the pathological characteristics of the patients included, patients with lymph node involvement predominated, totaling 44.9%, the presence of ulceration was observed in 64.3% of the cases, the peripheral margin was negative in 85.7% of the cases, the absence of microsatellites was observed in 76.2% of the cases, 49.3% of the patients had a Clark level 4 or 5. About 1/3 of the patients had nodular melanoma and the most frequent primary site was the back, making up 28.4% of the cases. In the study population, a median survival of 75.9 months was estimated, which is higher than that observed in the literature and which can be explained by the profile of the patients analyzed.Metástases cerebrais de melanoma são frequentes e estão associadas a um prognóstico ruim, estando associadas a 60-70% das mortes de pacientes com melanoma. Estima-se que aproximadamente um terço dos pacientes com melanoma metastático recém-diagnosticado apresentem metástases cerebrais sincrônicas. O presente estudo de coorte retrospectivo inclui pacientes atendidos no Hospital São Lucas da PUCRS, no período de 2007 a 2017 e tem por objetivo avaliar a sobrevida e descrever as características clinico patológicas desses pacientes. Foram incluídos todos os pacientes atendidos no serviço de oncologia com diagnóstico de melanoma metastático. Do total de pacientes com melanoma atendidos no ambulatório de oncologia do HSL-PUCRS, 67(12,3%) apresentavam metástases cerebrais. A maioria dos pacientes era do sexo masculino (67,2%) e mais da metade eram brancos (50,7%). Na primeira avaliação, 63,6% dos pacientes apresentava menos de 60 anos, a maioria não apresentava histórico familiar de melanoma (44,8%). Quando observamos as características relativas a anatomia patológica dos pacientes incluídos, predominaram os pacientes com envolvimento linfonodal, perfazendo 44,9%, a presença de ulceração foi observada em 64,3% dos casos, a margem periférica era negativa em 85,7% dos casos, a ausência de microssatelitose foi observada em 76,2% dos casos, 49,3 % dos pacientes apresentavam nível de Clark 4 ou 5. Cerca de um terço dos pacientes apresentavam melanoma nodular e o sítio primário mais frequente foi o dorso, perfazendo 28,4% dos casos. Na população em estudo, estimou-se uma mediana de sobrevida de 75,9 meses, dado este superior ao observado na literatura e que pode ser explicado pelo perfil dos pacientes analisadosSubmitted by PPG Medicina e Ciências da Saúde (medicina-pg@pucrs.br) on 2024-02-14T14:47:34Z No. of bitstreams: 1 Tese Matheus Ferla_rev.pdf: 799657 bytes, checksum: 342adc90652b38f5495f7c51ec72ff3c (MD5)Approved for entry into archive by Sarajane Pan (sarajane.pan@pucrs.br) on 2024-04-08T13:48:02Z (GMT) No. of bitstreams: 1 Tese Matheus Ferla_rev.pdf: 799657 bytes, checksum: 342adc90652b38f5495f7c51ec72ff3c (MD5)Made available in DSpace on 2024-04-08T13:54:34Z (GMT). No. of bitstreams: 1 Tese Matheus Ferla_rev.pdf: 799657 bytes, checksum: 342adc90652b38f5495f7c51ec72ff3c (MD5) Previous issue date: 2023-12-13application/pdfhttps://tede2.pucrs.br/tede2/retrieve/190103/DIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdf.jpgporPontifícia Universidade Católica do Rio Grande do SulPrograma de Pós-Graduação em Medicina e Ciências da SaúdePUCRSBrasilEscola de MedicinaMelanomaMetástases IntracranianasCirurgiaRadioterapiaTratamento ClínicoMelanomaIntracranial MetástasesSurgeryRadiotherapyClinical TreatmentCIENCIAS DA SAUDE::MEDICINAAvaliação da sobrevida e caracterização clinico-patológica de pacientes com melanoma metastático para o sistema nervoso centralinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisTrabalho será publicado como artigo ou livro60 meses08/04/2029-721401722658532398500500500-224747486637135387-969369452308786627info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAILDIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdf.jpgDIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdf.jpgimage/jpeg4078https://tede2.pucrs.br/tede2/bitstream/tede/11132/4/DIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdf.jpg7a3100ad54153e531fd47982f7ffc339MD54TEXTDIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdf.txtDIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdf.txttext/plain1153https://tede2.pucrs.br/tede2/bitstream/tede/11132/3/DIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdf.txteca646cc0a1386271ac7f441fafd3ddeMD53ORIGINALDIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdfDIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdfapplication/pdf474461https://tede2.pucrs.br/tede2/bitstream/tede/11132/2/DIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdfb800a382ebf273230dafca9dbd4293ceMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8590https://tede2.pucrs.br/tede2/bitstream/tede/11132/1/license.txt220e11f2d3ba5354f917c7035aadef24MD51tede/111322024-04-08 12:00:18.513oai:tede2.pucrs.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2024-04-08T15:00:18Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.por.fl_str_mv |
Avaliação da sobrevida e caracterização clinico-patológica de pacientes com melanoma metastático para o sistema nervoso central |
title |
Avaliação da sobrevida e caracterização clinico-patológica de pacientes com melanoma metastático para o sistema nervoso central |
spellingShingle |
Avaliação da sobrevida e caracterização clinico-patológica de pacientes com melanoma metastático para o sistema nervoso central Ferla, Matheus dos Santos Melanoma Metástases Intracranianas Cirurgia Radioterapia Tratamento Clínico Melanoma Intracranial Metástases Surgery Radiotherapy Clinical Treatment CIENCIAS DA SAUDE::MEDICINA |
title_short |
Avaliação da sobrevida e caracterização clinico-patológica de pacientes com melanoma metastático para o sistema nervoso central |
title_full |
Avaliação da sobrevida e caracterização clinico-patológica de pacientes com melanoma metastático para o sistema nervoso central |
title_fullStr |
Avaliação da sobrevida e caracterização clinico-patológica de pacientes com melanoma metastático para o sistema nervoso central |
title_full_unstemmed |
Avaliação da sobrevida e caracterização clinico-patológica de pacientes com melanoma metastático para o sistema nervoso central |
title_sort |
Avaliação da sobrevida e caracterização clinico-patológica de pacientes com melanoma metastático para o sistema nervoso central |
author |
Ferla, Matheus dos Santos |
author_facet |
Ferla, Matheus dos Santos |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Fay, André Poisl |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6858336633023217 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7759618134806078 |
dc.contributor.author.fl_str_mv |
Ferla, Matheus dos Santos |
contributor_str_mv |
Fay, André Poisl |
dc.subject.por.fl_str_mv |
Melanoma Metástases Intracranianas Cirurgia Radioterapia Tratamento Clínico |
topic |
Melanoma Metástases Intracranianas Cirurgia Radioterapia Tratamento Clínico Melanoma Intracranial Metástases Surgery Radiotherapy Clinical Treatment CIENCIAS DA SAUDE::MEDICINA |
dc.subject.eng.fl_str_mv |
Melanoma Intracranial Metástases Surgery Radiotherapy Clinical Treatment |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA |
description |
Brain metastases from melanoma are frequent and are associated with a poor prognosis. They are associated with 60-70% of deaths in patients with melanoma. It is estimated that approximately one third of patients with newly diagnosed metastatic melanoma have synchronous radial metastases. This retrospective cohort study includes patients treated at Hospital São Lucas da PUCRS, from 2007 to 2017 and aims to evaluate survival and describe the clinicopathological characteristics of these patients.. All patients treated at the oncology service with a diagnosis of metastatic melanoma were included. Of the total number of patients with melanoma treated at the HSL-PUCRS oncology outpatient clinic, 67 (12.3%) had brain metastases. Most patients were male (67.2%) and more than half were white (50.7%). At the first evaluation, 63.6% of the patients were younger than 60 years, most had no family history of melanoma (44.8%). When we observed the pathological characteristics of the patients included, patients with lymph node involvement predominated, totaling 44.9%, the presence of ulceration was observed in 64.3% of the cases, the peripheral margin was negative in 85.7% of the cases, the absence of microsatellites was observed in 76.2% of the cases, 49.3% of the patients had a Clark level 4 or 5. About 1/3 of the patients had nodular melanoma and the most frequent primary site was the back, making up 28.4% of the cases. In the study population, a median survival of 75.9 months was estimated, which is higher than that observed in the literature and which can be explained by the profile of the patients analyzed. |
publishDate |
2023 |
dc.date.issued.fl_str_mv |
2023-12-13 |
dc.date.accessioned.fl_str_mv |
2024-04-08T13:54:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://tede2.pucrs.br/tede2/handle/tede/11132 |
url |
https://tede2.pucrs.br/tede2/handle/tede/11132 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
-721401722658532398 |
dc.relation.confidence.fl_str_mv |
500 500 500 |
dc.relation.department.fl_str_mv |
-224747486637135387 |
dc.relation.cnpq.fl_str_mv |
-969369452308786627 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Pontifícia Universidade Católica do Rio Grande do Sul |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Medicina e Ciências da Saúde |
dc.publisher.initials.fl_str_mv |
PUCRS |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Escola de Medicina |
publisher.none.fl_str_mv |
Pontifícia Universidade Católica do Rio Grande do Sul |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Biblioteca Digital de Teses e Dissertações da PUC_RS |
collection |
Biblioteca Digital de Teses e Dissertações da PUC_RS |
bitstream.url.fl_str_mv |
https://tede2.pucrs.br/tede2/bitstream/tede/11132/4/DIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdf.jpg https://tede2.pucrs.br/tede2/bitstream/tede/11132/3/DIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdf.txt https://tede2.pucrs.br/tede2/bitstream/tede/11132/2/DIS_MATHEUS_DOS_SANTOS_FERLA_CONFIDENCIAL.pdf https://tede2.pucrs.br/tede2/bitstream/tede/11132/1/license.txt |
bitstream.checksum.fl_str_mv |
7a3100ad54153e531fd47982f7ffc339 eca646cc0a1386271ac7f441fafd3dde b800a382ebf273230dafca9dbd4293ce 220e11f2d3ba5354f917c7035aadef24 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
biblioteca.central@pucrs.br|| |
_version_ |
1799765538547695616 |