Associação entre obesidade visceral, esteatose hepática, aterosclerose assintomática, inflamação e síndrome metabólica em pessoas idosas

• Ano de defesa: 2023
• Autor(a) principal: Petter, Jobe
• Orientador(a): Moraes, Clayton Franco
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Católica de Brasília
• Programa de Pós-Graduação: Programa Stricto Sensu em Gerontologia
• Departamento: Escola de Saúde e Medicina
• País: Brasil
• Palavras-chave em Português: Idosos; Obesidade; Esteatose hepática; Aterosclerose; Ultrassonografia; Inflamação
• Palavras-chave em Inglês: Elderly; Obesity; Fatty Liver; Atherosclerosis; Ultrasonography; Inflammation
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE
• Link de acesso: https://bdtd.ucb.br:8443/jspui/handle/tede/3237

The world population is aging. In the last decade, the elderly population has increased by 34% in the Federal District. On the other hand, the World Health Organization estimates that 13% of the world population is obese. Visceral obesity plays a fundamental role in Metabolic Syndrome (MS), being a mandatory criterion. By ultrasonography, visceral fat deposits and carotid atherosclerosis can be detected. OBJECTIVE: To determine the usefulness of ultrasonographic detection of non-alcoholic hepatic steatosis and visceral fat measurements as risk markers for carotid atherosclerosis in elderly individuals, and to verify whether there is inflammatory mediation between these processes. METHODS: Cross-sectional observational study of a sample of 107 elderly individuals from the Federal District of Rio de Janeiro, in whom ultrasonographic measurements of the carotid arteries mid-intimal layer and intra-abdominal fat deposits were performed, in addition to blood samples were collected for blood work to calculate the neutrophil-to-lymphocyte ratio (an inflammation marker), lipid work and fasting glycemia. RESULTS: The following significant associations (p < 0.05) were found: Atherosclerosis in the carotid system with age, smoking, Neutrophil-to-Lymphocyte Ratio (NLR) and Triglyceride/HDLc Ratio; MS with intra-abdominal fat thickness (IAFT) and hepatorenal fat thickness (HRFT); IAFT with moderate/severe hepatic steatosis (MSHE); and, MSHE with thickening of the mid-intimal layer of the left internal carotid artery. CONCLUSION: Intra-abdominal fat thickness is related to EHMA and steatosis, to this degree, is related to atherosclerosis, but it was not possible to determine that this relationship is mediated by inflammation (NLR). Intra-abdominal fat thickness and fat in the hepatorenal space are associated with metabolic syndrome. Atherosclerosis is associated with age, current or past smoking, dyslipidemia (TGC/HDLc ratio) and inflammation (NLR).