Níveis séricos de ácido úrico e as atividades a superóxido dismutase e da catalase nos transtornos de humor

• Ano de defesa: 2010
• Autor(a) principal: Wiener, Carolina David
• Orientador(a): Oses, Jean Pierre
• Banca de defesa: Moreira, Júlia Dubois , Pinheiro, Karen Amaral Tavares
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Catolica de Pelotas
• Programa de Pós-Graduação: Programa de Pos-Graduacao em Saude Comportamento#; #-1990782970254042025#; #600
• Departamento: Centro de Ciencias da Saude#; #-7432574962795991241#; #600
• País: Brasil
• Palavras-chave em Português: estresse oxidativo; ácido úrico; catalase; superóxido dismutase; transtornos de humor; marcadores bioquímicos
• Área do conhecimento CNPq: CIENCIAS DA SAUDE#; #8765449414823306929#; #600
• Link de acesso: http://tede.ucpel.edu.br:8080/jspui/handle/tede/500

Objectives: The aim of this study was evaluate uric acid level in a population–based sample of young adults (18 to 24 years old). People with bipolar and depression disorder were compared with healthy psychiatric subjects without a history of mood episodes. Methods: Case-control study nested in a population-based sample. The diagnosis was confirmed with the Structured Clinical Interview for DSM-IV. The uric acid was assessed by commercial kits Results: The sample consisted of 216 subjects, 49 with diagnosis for bipolar disorder, 76 with depression and 91 population control. The uric acid levels were similar (control = 4.08 ± 1.27 mg/dL, depression = 3.78 ± 1.00 mg/dL e bipolar disorder =3.86 ± 1.33 mg/dL, p= 0,251). For maniac/hippomaniac and depressive episodes, were observed a tendency to increase in acid uric levels in maniac/hippomaniac episodes (4.43 ± 1.74 mg/dL) and a decrease in depressive episodes (3.70 ± 0.99 mg/dL) when compared to control subjects (4.08 ± 1.27 mg/dL)(p= 0.106). Conclusion: Uric acid levels is not correlated with diagnosis group, but the uric acid level have a tendency to presented increased in manic and/ or mixed episodes and decreased in depression episode, these result observed that levels of uric acid in mood disorders are altered according to the manifestation of symptoms.