Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae)
Ano de defesa: | 2012 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Estadual de Feira de Santana
|
Programa de Pós-Graduação: |
Doutorado Acad?mico em Biotecnologia
|
Departamento: |
DEPARTAMENTO DE TECNOLOGIA
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://tede2.uefs.br:8080/handle/tede/973 |
Resumo: | The species Lippia thymoides (Verbenaceae), popularly known as ?alecrim do mato? or ?alecrim do campo?, is used in the folk medicine to treat wounds, bronchitis, rheumatism and fever. In this work was investigated the phytochemical and pharmacological profile oh this species, correlating with its popular use. Essential oils obtained in the four seasons had as majoritary constituent the sesquiterpene ?-caryophyllene. The species L. thymoides presented potent antioxidant activity in the DPPH assay, probably due to elevated content of phenolics. Essential oils inhibited the growth of bacteria Staphylococcus aureus, while the dichlorometane and ethyl acetate fractions from leaves and stems methanolic extracts inhibited the growth of S. aureus, Micrococcus luteus and Bacillus cereus. Methanolic extracts from leaves and stems not stimulated the cutaneous wound healing in rats. Methanolic extract from leaves significantly reduced the rectal temperature in rats submitted to hyperthermia induced by hyperpyrexia with injection of the Saccharomyces cerevisiae. Essential oil these specie presented antinociceptive activity in mices, probably due to anti-inflammatory effect of b-caryophyllene, 1,8-cineole, camphene and borneol. The specie L. thymoides presented spasmolytic activity in vitro in isolated organs, with the essential oils relaxing rat uterus and rat aorta of endothelium-independent manner and methanolic extracts and fractions from leaves and stems relaxing guinea-pig trachea smooth muscles. This last effect might be related to competitive antagonism with muscarinic receptors, as it was observed with the dichloromethane fraction from methanolic extract of the leaves. These results showed that L. thymoides is a source of substances of pharmaceutical interest, explaining partially the folk use of this species to treat wounds, rheumatism, fever and bronchitis. |
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Lucchese, Ang?lica MariaLima, Julianeli Tolentino deAlmeida, Jackson Roberto Guedes da Silva00127281525http://lattes.cnpq.br/7061608208191249Silva, Fabr?cio Souza2020-03-05T19:08:51Z2012-10-19SILVA, Fabr?cio Souza. Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae). 2012. 173 f. Tese (Doutorado Acad?mico em Biotecnologia)- Universidade Estadual de Feira de Santana, Feira de Santana, 2012.http://tede2.uefs.br:8080/handle/tede/973The species Lippia thymoides (Verbenaceae), popularly known as ?alecrim do mato? or ?alecrim do campo?, is used in the folk medicine to treat wounds, bronchitis, rheumatism and fever. In this work was investigated the phytochemical and pharmacological profile oh this species, correlating with its popular use. Essential oils obtained in the four seasons had as majoritary constituent the sesquiterpene ?-caryophyllene. The species L. thymoides presented potent antioxidant activity in the DPPH assay, probably due to elevated content of phenolics. Essential oils inhibited the growth of bacteria Staphylococcus aureus, while the dichlorometane and ethyl acetate fractions from leaves and stems methanolic extracts inhibited the growth of S. aureus, Micrococcus luteus and Bacillus cereus. Methanolic extracts from leaves and stems not stimulated the cutaneous wound healing in rats. Methanolic extract from leaves significantly reduced the rectal temperature in rats submitted to hyperthermia induced by hyperpyrexia with injection of the Saccharomyces cerevisiae. Essential oil these specie presented antinociceptive activity in mices, probably due to anti-inflammatory effect of b-caryophyllene, 1,8-cineole, camphene and borneol. The specie L. thymoides presented spasmolytic activity in vitro in isolated organs, with the essential oils relaxing rat uterus and rat aorta of endothelium-independent manner and methanolic extracts and fractions from leaves and stems relaxing guinea-pig trachea smooth muscles. This last effect might be related to competitive antagonism with muscarinic receptors, as it was observed with the dichloromethane fraction from methanolic extract of the leaves. These results showed that L. thymoides is a source of substances of pharmaceutical interest, explaining partially the folk use of this species to treat wounds, rheumatism, fever and bronchitis.A esp?cie Lippia thymoides (Verbenaceae), conhecida popularmente como alecrim do mato ou alecrim do campo, ? utilizada na medicina tradicional para o tratamento de feridas, bronquite, reumatismo e febre. Neste trabalho foi investigado o perfil fitoqu?mico e farmacol?gico dessa esp?cie, correlacionando com o uso popular. Os ?leos essenciais obtidos nas quatro esta??es climatol?gicas tiveram como constituinte majorit?rio o sesquiterpeno ?-cariofileno. A esp?cie L. thymoides apresentou potente atividade antioxidante no ensaio de sequestro do radical DPPH, provavelmente devido ao alto teor de constituintes fen?licos. Os ?leos essenciais inibiram o crescimento da bact?ria Staphylococcus aureus, enquanto que as fra??es diclorometano e acetato de etila dos extratos metan?licos das folhas e caules inibiram o crescimento de S.?aureus, Micrococcus luteus e Bacillus cereus. Os extratos metan?licos das folhas e caules de L. thymoides n?o estimularam a cicatriza??o de feridas cut?neas em ratos. O extrato metan?lico das folhas significantemente reduziu a temperatura retal de ratos submetidos ao ensaio de hipertermia induzida por hiperpirexia com inje??o de Saccharomyces cerevisiae. O ?leo essencial dessa esp?cie apresentou atividade antinociceptiva em camundongos, provavelmente pelo efeito anti-inflamat?rio do ?-cariofileno, 1,8-cineol, canfeno e borneol. A esp?cie L.?thymoides apresentou atividade espasmol?tica in vitro em ?rg?os isolados, com os ?leos essenciais relaxando ?tero de rata e aorta de rato de maneira independente do endot?lio, enquanto que os extratos metan?licos e fra??es das folhas e caules apresentaram atividade espasmol?tica em traqueia de cobaia. Este ?ltimo efeito pode estar relacionado ao antagonismo competitivo com receptores muscar?nicos, conforme foi observado com a fra??o diclorometano do extrato metan?lico das folhas. Os resultados demonstram que L.?thymoides ? uma fonte de subst?ncias de interesse farmac?utico, explicando parcialmente a utiliza??o popular dessa esp?cie no tratamento de feridas, reumatismo, febre e bronquite.Submitted by Carolina Neves (carolinapon@uefs.br) on 2020-03-05T19:08:51Z No. of bitstreams: 1 Tese - Fabricio S. Silva.pdf: 2466421 bytes, checksum: 23f49dc33e38a42bc1a545389ff487b1 (MD5)Made available in DSpace on 2020-03-05T19:08:51Z (GMT). No. of bitstreams: 1 Tese - Fabricio S. Silva.pdf: 2466421 bytes, checksum: 23f49dc33e38a42bc1a545389ff487b1 (MD5) Previous issue date: 2012-10-19Funda??o de Amparo ? Pesquisa do Estado da Bahia - FAPEBapplication/pdfporUniversidade Estadual de Feira de SantanaDoutorado Acad?mico em BiotecnologiaUEFSBrasilDEPARTAMENTO DE TECNOLOGIAVerbenaceaeLippia thymoides?leo essencialFebreAtividade antimicrobianaRelaxamento de m?sculo lisoEssential oilFeverAntimicrobial activitySmooth muscle relaxationCIENCIAS BIOLOGICAS::FARMACOLOGIACIENCIAS BIOLOGICASEstudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis-68152692297897915436006006006006004335108523020347051700814650651154363-3439178843068202161-8233071094704392586info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UEFSinstname:Universidade Estadual de Feira de Santana (UEFS)instacron:UEFSORIGINALTese - Fabricio S. Silva.pdfTese - Fabricio S. Silva.pdfapplication/pdf2466421http://tede2.uefs.br:8080/bitstream/tede/973/2/Tese+-+Fabricio+S.+Silva.pdf23f49dc33e38a42bc1a545389ff487b1MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://tede2.uefs.br:8080/bitstream/tede/973/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51tede/9732020-03-05 16:08:51.611oai:tede2.uefs.br:8080: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.uefs.br:8080/PUBhttp://tede2.uefs.br:8080/oai/requestbcuefs@uefs.br|| bcref@uefs.br||bcuefs@uefs.bropendoar:2020-03-05T19:08:51Biblioteca Digital de Teses e Dissertações da UEFS - Universidade Estadual de Feira de Santana (UEFS)false |
dc.title.por.fl_str_mv |
Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae) |
title |
Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae) |
spellingShingle |
Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae) Silva, Fabr?cio Souza Verbenaceae Lippia thymoides ?leo essencial Febre Atividade antimicrobiana Relaxamento de m?sculo liso Essential oil Fever Antimicrobial activity Smooth muscle relaxation CIENCIAS BIOLOGICAS::FARMACOLOGIA CIENCIAS BIOLOGICAS |
title_short |
Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae) |
title_full |
Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae) |
title_fullStr |
Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae) |
title_full_unstemmed |
Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae) |
title_sort |
Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae) |
author |
Silva, Fabr?cio Souza |
author_facet |
Silva, Fabr?cio Souza |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Lucchese, Ang?lica Maria |
dc.contributor.advisor-co1.fl_str_mv |
Lima, Julianeli Tolentino de |
dc.contributor.advisor-co2.fl_str_mv |
Almeida, Jackson Roberto Guedes da Silva |
dc.contributor.authorID.fl_str_mv |
00127281525 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7061608208191249 |
dc.contributor.author.fl_str_mv |
Silva, Fabr?cio Souza |
contributor_str_mv |
Lucchese, Ang?lica Maria Lima, Julianeli Tolentino de Almeida, Jackson Roberto Guedes da Silva |
dc.subject.por.fl_str_mv |
Verbenaceae Lippia thymoides ?leo essencial Febre Atividade antimicrobiana Relaxamento de m?sculo liso |
topic |
Verbenaceae Lippia thymoides ?leo essencial Febre Atividade antimicrobiana Relaxamento de m?sculo liso Essential oil Fever Antimicrobial activity Smooth muscle relaxation CIENCIAS BIOLOGICAS::FARMACOLOGIA CIENCIAS BIOLOGICAS |
dc.subject.eng.fl_str_mv |
Essential oil Fever Antimicrobial activity Smooth muscle relaxation |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::FARMACOLOGIA CIENCIAS BIOLOGICAS |
description |
The species Lippia thymoides (Verbenaceae), popularly known as ?alecrim do mato? or ?alecrim do campo?, is used in the folk medicine to treat wounds, bronchitis, rheumatism and fever. In this work was investigated the phytochemical and pharmacological profile oh this species, correlating with its popular use. Essential oils obtained in the four seasons had as majoritary constituent the sesquiterpene ?-caryophyllene. The species L. thymoides presented potent antioxidant activity in the DPPH assay, probably due to elevated content of phenolics. Essential oils inhibited the growth of bacteria Staphylococcus aureus, while the dichlorometane and ethyl acetate fractions from leaves and stems methanolic extracts inhibited the growth of S. aureus, Micrococcus luteus and Bacillus cereus. Methanolic extracts from leaves and stems not stimulated the cutaneous wound healing in rats. Methanolic extract from leaves significantly reduced the rectal temperature in rats submitted to hyperthermia induced by hyperpyrexia with injection of the Saccharomyces cerevisiae. Essential oil these specie presented antinociceptive activity in mices, probably due to anti-inflammatory effect of b-caryophyllene, 1,8-cineole, camphene and borneol. The specie L. thymoides presented spasmolytic activity in vitro in isolated organs, with the essential oils relaxing rat uterus and rat aorta of endothelium-independent manner and methanolic extracts and fractions from leaves and stems relaxing guinea-pig trachea smooth muscles. This last effect might be related to competitive antagonism with muscarinic receptors, as it was observed with the dichloromethane fraction from methanolic extract of the leaves. These results showed that L. thymoides is a source of substances of pharmaceutical interest, explaining partially the folk use of this species to treat wounds, rheumatism, fever and bronchitis. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-10-19 |
dc.date.accessioned.fl_str_mv |
2020-03-05T19:08:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Fabr?cio Souza. Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae). 2012. 173 f. Tese (Doutorado Acad?mico em Biotecnologia)- Universidade Estadual de Feira de Santana, Feira de Santana, 2012. |
dc.identifier.uri.fl_str_mv |
http://tede2.uefs.br:8080/handle/tede/973 |
identifier_str_mv |
SILVA, Fabr?cio Souza. Estudo fitoqu?mico e farmacol?gico de Lippia thymoides Mart. & Schauer (Verbenaceae). 2012. 173 f. Tese (Doutorado Acad?mico em Biotecnologia)- Universidade Estadual de Feira de Santana, Feira de Santana, 2012. |
url |
http://tede2.uefs.br:8080/handle/tede/973 |
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por |
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Universidade Estadual de Feira de Santana |
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