Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais
Ano de defesa: | 2022 |
---|---|
Autor(a) principal: | |
Outros Autores: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade do Estado do Rio de Janeiro
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Engenharia Ambiental
|
Departamento: |
Centro de Tecnologia e Ciências::Faculdade de Engenharia
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://www.bdtd.uerj.br/handle/1/18058 |
Resumo: | Antiviral drugs are class of medications used to treat the human immunodeficiency virus (HIV) and other viral infections. Due to their wide use in developing countries, these compounds have already been reported in several aquatic environments, while data on the risk they may pose to non-target species are scarce.This study aims to evaluate the environmental risk of antivirals and their chronic effects using two species of aquatic organisms, in addition to investigating the embryotoxicity to Daphnia similis. The results with R. subcapitata showed the following toxicities: zidovudine (CI50 = 5.442 mg L-1) < acyclovir (CI50 = 3.612 mg L-1) < lamivudine (CI50 = 3.013 mg L-1) < efavirenz (CI50 = 0.034 mg L-1). The results of the chronic bioassay with C. dubia demonstrated that zidovudine is the least toxic (CE50 = 5.671 mg L-1), followed by acyclovir (CE50 = 3.062 mg L-1), lamivudine (CE50 = 1.345 mg L-1) and efavirenz (CE50 = 0.026 mg L-1). Both species have been shown to be sensitive to efavirenz. A risk quotient (RQ) was calculated, and efavirenz had an RQ greater than 1 for both species, and lamivudine had an RQ greater than 1 for C. dubia, representing a high ecological risk for these organisms. Subsequently, a risk assessment was performed for antiviral mixtures identified as presenting relatively high risks to aquatic organisms. The results of the embryotoxicity assay of the four antivirals revealed that these drugs induced various abnormalities such as interruption of embryonic development and abnormalities in the carapace, antennae and caudal spine. The Daphnia embryo model was considered adequate to assess toxicity during embryonic development, which may compromise the survival of species in environments with the presence of antivirals. Antivirals pose a significant environmental risk to aquatic organisms and must be taken into account in future monitoring of water bodies. |
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Bila, Daniele Maiahttp://lattes.cnpq.br/1791743137921382Figueiredo, Natália Guimarães dehttp://lattes.cnpq.br/0041628021132059Salomão, André Luis de Sáhttp://lattes.cnpq.br/3462722644841920Geraldino, Barbara Rodrigueshttp://lattes.cnpq.br/2970796031825692Poça, Katia Soares dahttp://lattes.cnpq.br/7161272888879163Daflon, Sarah Dario Alveshttp://lattes.cnpq.br/7002833849217073http://lattes.cnpq.br/6915421724981119Cunha, Ludmila da Silvaludmilacunhabio@gmail.com2022-07-14T21:00:39Z2022-04-06CUNHA, Ludmila da Silva. Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais. 2022. 248 f. Tese (Doutorado em Engenharia Ambiental) - Faculdade de Engenharia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2022.http://www.bdtd.uerj.br/handle/1/18058Antiviral drugs are class of medications used to treat the human immunodeficiency virus (HIV) and other viral infections. Due to their wide use in developing countries, these compounds have already been reported in several aquatic environments, while data on the risk they may pose to non-target species are scarce.This study aims to evaluate the environmental risk of antivirals and their chronic effects using two species of aquatic organisms, in addition to investigating the embryotoxicity to Daphnia similis. The results with R. subcapitata showed the following toxicities: zidovudine (CI50 = 5.442 mg L-1) < acyclovir (CI50 = 3.612 mg L-1) < lamivudine (CI50 = 3.013 mg L-1) < efavirenz (CI50 = 0.034 mg L-1). The results of the chronic bioassay with C. dubia demonstrated that zidovudine is the least toxic (CE50 = 5.671 mg L-1), followed by acyclovir (CE50 = 3.062 mg L-1), lamivudine (CE50 = 1.345 mg L-1) and efavirenz (CE50 = 0.026 mg L-1). Both species have been shown to be sensitive to efavirenz. A risk quotient (RQ) was calculated, and efavirenz had an RQ greater than 1 for both species, and lamivudine had an RQ greater than 1 for C. dubia, representing a high ecological risk for these organisms. Subsequently, a risk assessment was performed for antiviral mixtures identified as presenting relatively high risks to aquatic organisms. The results of the embryotoxicity assay of the four antivirals revealed that these drugs induced various abnormalities such as interruption of embryonic development and abnormalities in the carapace, antennae and caudal spine. The Daphnia embryo model was considered adequate to assess toxicity during embryonic development, which may compromise the survival of species in environments with the presence of antivirals. Antivirals pose a significant environmental risk to aquatic organisms and must be taken into account in future monitoring of water bodies.Os antivirais são uma classe de medicamentos usados no tratamento do vírus da imunodeficiência humana (HIV) e outras infecções virais. Devido ao seu amplo uso em países em desenvolvimento, esses compostos já foram encontrados em diversos ambientes aquáticos e os dados sobre o risco que podem representar para espécies não-alvo são escassos. Este estudo tem como objetivo avaliar o risco ambiental de antivirais e seus efeitos crônicos utilizando duas espécies de organismos aquáticos, além de investigar a embriotoxicidade destes fármacos para Daphnia similis. Os resultados de tocixidade com R. subcapitata foram: zidovudina (CI50 = 5,442 mg L-1) < aciclovir (CI50 = 3,612 mg L-1) < lamivudina (CI50 = 3,013 mg L-1) < efavirenz (CI50 = 0,034 mg L-1). Os resultados do ensaio crônico com C. dubia demonstraram que a zidovudina foi a menos tóxica (CE50 = 5,671 mg L-1), seguida pelo aciclovir (CE50 = 3,062 mg L-1), lamivudina (CE50 = 1,345 mg L-1) e efavirenz (CE50 = 0,026 mg L-1). Ambas as espécies demonstraram ser sensíveis ao efavirenz. A análise de risco ambiental nas águas superficiais dos rios revelou ser alto (Quociente de Risco > 1) com o uso do efavirenz e lamivudina para R. subcapitata e C. dubia. Posteriormente, foi realizada uma avaliação de risco para misturas de antiviriais que identificou riscos muito altos para os organismos aquáticos. Os resultados do ensaio de embriotoxicidade dos quatro antivirais revelaram que esses fármacos induziram anormalidades variadas como interrupção do desenvolvimento embrionário e anormalidades na carapaça, antenas e do espinho caudal. O modelo de embrião de Daphnia foi considerado adequado para avaliar a toxicidade de micropoluentes durante o desenvolvimento embrionário o que pode comprometer à sobrevivência de espécies em ambientes com a presença dos antivirais. Os antivirais representam um risco ambiental significativo para os organismos aquáticos e devem ser levados em consideração no monitoramento futuro dos corpos hídricos.Submitted by Julia CTC/B (julia.vieira@uerj.br) on 2022-07-14T21:00:39Z No. of bitstreams: 1 Tese - Ludmila da Silva Cunha - 2022 - Completo.pdf: 3316327 bytes, checksum: 11fc84e68e542f58f89784b07f5c914e (MD5)Made available in DSpace on 2022-07-14T21:00:39Z (GMT). No. of bitstreams: 1 Tese - Ludmila da Silva Cunha - 2022 - Completo.pdf: 3316327 bytes, checksum: 11fc84e68e542f58f89784b07f5c914e (MD5) Previous issue date: 2022-04-06application/pdfporUniversidade do Estado do Rio de JaneiroPrograma de Pós-Graduação em Engenharia AmbientalUERJBrasilCentro de Tecnologia e Ciências::Faculdade de EngenhariaEnvironmental engineeringEnvironmental toxicologyMedicinesAntiviral agentsEnvironmental impact - AssessmentEngenharia ambientalToxicologia ambientalMedicamentosAgentes antiviraisImpacto ambiental - AvaliaçãoENGENHARIAS::ENGENHARIA SANITARIA::SANEAMENTO AMBIENTAL::CONTROLE DA POLUICAOToxicidade crônica, embriotoxicidade e análise de risco ambiental de antiviraisChronic toxicity, embryotoxicity and environmental risk analysis of antiviralsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UERJinstname:Universidade do Estado do Rio de Janeiro (UERJ)instacron:UERJORIGINALTese - Ludmila da Silva Cunha - 2022 - Completo.pdfTese - Ludmila da Silva Cunha - 2022 - Completo.pdfapplication/pdf3316327http://www.bdtd.uerj.br/bitstream/1/18058/2/Tese+-+Ludmila+da+Silva+Cunha+-+2022+-+Completo.pdf11fc84e68e542f58f89784b07f5c914eMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82123http://www.bdtd.uerj.br/bitstream/1/18058/1/license.txte5502652da718045d7fcd832b79fca29MD511/180582024-02-27 14:46:40.369oai:www.bdtd.uerj.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.bdtd.uerj.br/PUBhttps://www.bdtd.uerj.br:8443/oai/requestbdtd.suporte@uerj.bropendoar:29032024-02-27T17:46:40Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ)false |
dc.title.por.fl_str_mv |
Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais |
dc.title.alternative.eng.fl_str_mv |
Chronic toxicity, embryotoxicity and environmental risk analysis of antivirals |
title |
Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais |
spellingShingle |
Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais Cunha, Ludmila da Silva Environmental engineering Environmental toxicology Medicines Antiviral agents Environmental impact - Assessment Engenharia ambiental Toxicologia ambiental Medicamentos Agentes antivirais Impacto ambiental - Avaliação ENGENHARIAS::ENGENHARIA SANITARIA::SANEAMENTO AMBIENTAL::CONTROLE DA POLUICAO |
title_short |
Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais |
title_full |
Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais |
title_fullStr |
Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais |
title_full_unstemmed |
Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais |
title_sort |
Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais |
author |
Cunha, Ludmila da Silva |
author_facet |
Cunha, Ludmila da Silva ludmilacunhabio@gmail.com |
author_role |
author |
author2 |
ludmilacunhabio@gmail.com |
author2_role |
author |
dc.contributor.advisor1.fl_str_mv |
Bila, Daniele Maia |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1791743137921382 |
dc.contributor.advisor-co1.fl_str_mv |
Figueiredo, Natália Guimarães de |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/0041628021132059 |
dc.contributor.referee1.fl_str_mv |
Salomão, André Luis de Sá |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/3462722644841920 |
dc.contributor.referee2.fl_str_mv |
Geraldino, Barbara Rodrigues |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/2970796031825692 |
dc.contributor.referee3.fl_str_mv |
Poça, Katia Soares da |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/7161272888879163 |
dc.contributor.referee4.fl_str_mv |
Daflon, Sarah Dario Alves |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/7002833849217073 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6915421724981119 |
dc.contributor.author.fl_str_mv |
Cunha, Ludmila da Silva ludmilacunhabio@gmail.com |
contributor_str_mv |
Bila, Daniele Maia Figueiredo, Natália Guimarães de Salomão, André Luis de Sá Geraldino, Barbara Rodrigues Poça, Katia Soares da Daflon, Sarah Dario Alves |
dc.subject.eng.fl_str_mv |
Environmental engineering Environmental toxicology Medicines Antiviral agents Environmental impact - Assessment |
topic |
Environmental engineering Environmental toxicology Medicines Antiviral agents Environmental impact - Assessment Engenharia ambiental Toxicologia ambiental Medicamentos Agentes antivirais Impacto ambiental - Avaliação ENGENHARIAS::ENGENHARIA SANITARIA::SANEAMENTO AMBIENTAL::CONTROLE DA POLUICAO |
dc.subject.por.fl_str_mv |
Engenharia ambiental Toxicologia ambiental Medicamentos Agentes antivirais Impacto ambiental - Avaliação |
dc.subject.cnpq.fl_str_mv |
ENGENHARIAS::ENGENHARIA SANITARIA::SANEAMENTO AMBIENTAL::CONTROLE DA POLUICAO |
description |
Antiviral drugs are class of medications used to treat the human immunodeficiency virus (HIV) and other viral infections. Due to their wide use in developing countries, these compounds have already been reported in several aquatic environments, while data on the risk they may pose to non-target species are scarce.This study aims to evaluate the environmental risk of antivirals and their chronic effects using two species of aquatic organisms, in addition to investigating the embryotoxicity to Daphnia similis. The results with R. subcapitata showed the following toxicities: zidovudine (CI50 = 5.442 mg L-1) < acyclovir (CI50 = 3.612 mg L-1) < lamivudine (CI50 = 3.013 mg L-1) < efavirenz (CI50 = 0.034 mg L-1). The results of the chronic bioassay with C. dubia demonstrated that zidovudine is the least toxic (CE50 = 5.671 mg L-1), followed by acyclovir (CE50 = 3.062 mg L-1), lamivudine (CE50 = 1.345 mg L-1) and efavirenz (CE50 = 0.026 mg L-1). Both species have been shown to be sensitive to efavirenz. A risk quotient (RQ) was calculated, and efavirenz had an RQ greater than 1 for both species, and lamivudine had an RQ greater than 1 for C. dubia, representing a high ecological risk for these organisms. Subsequently, a risk assessment was performed for antiviral mixtures identified as presenting relatively high risks to aquatic organisms. The results of the embryotoxicity assay of the four antivirals revealed that these drugs induced various abnormalities such as interruption of embryonic development and abnormalities in the carapace, antennae and caudal spine. The Daphnia embryo model was considered adequate to assess toxicity during embryonic development, which may compromise the survival of species in environments with the presence of antivirals. Antivirals pose a significant environmental risk to aquatic organisms and must be taken into account in future monitoring of water bodies. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-07-14T21:00:39Z |
dc.date.issued.fl_str_mv |
2022-04-06 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CUNHA, Ludmila da Silva. Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais. 2022. 248 f. Tese (Doutorado em Engenharia Ambiental) - Faculdade de Engenharia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2022. |
dc.identifier.uri.fl_str_mv |
http://www.bdtd.uerj.br/handle/1/18058 |
identifier_str_mv |
CUNHA, Ludmila da Silva. Toxicidade crônica, embriotoxicidade e análise de risco ambiental de antivirais. 2022. 248 f. Tese (Doutorado em Engenharia Ambiental) - Faculdade de Engenharia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2022. |
url |
http://www.bdtd.uerj.br/handle/1/18058 |
dc.language.iso.fl_str_mv |
por |
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por |
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Universidade do Estado do Rio de Janeiro |
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dc.publisher.initials.fl_str_mv |
UERJ |
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Brasil |
dc.publisher.department.fl_str_mv |
Centro de Tecnologia e Ciências::Faculdade de Engenharia |
publisher.none.fl_str_mv |
Universidade do Estado do Rio de Janeiro |
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