Efeitos biológicos do exercício de vibração de corpo inteiro (EVCI) e de sua associação com um extrato aquoso de Coriandrum sativum (coentro) em ratos Wistar com e sem diabetes do tipo 1

• Ano de defesa: 2018
• Autor(a) principal: Frederico, Éric Heleno Freire Ferreira
• Orientador(a): Bernardo-Filho, Mario
• Banca de defesa: Pôrto, Luís Cristóvão de Moraes Sobrino , Bergmann, Anke , Caputo, Danúbia da Cunha de Sá
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Estado do Rio de Janeiro
• Programa de Pós-Graduação: Programa de Pós-Graduação em Biociências
• Departamento: Centro Biomédico::Instituto de Biologia Roberto Alcantara Gomes
• País: BR
• Palavras-chave em Português: EVCI; Coentro; Biodistribuição; Biomarcadores; Massa corporal; Consumo de ração; Consistência das fezes; Diabetes; Plantas medicinais; Matéria médica vegetal; Coriandrum; Biomarcadores farmacológicos
• Palavras-chave em Inglês: WBV exercise; Coriander; Biodistribution; Biomarkers; Body mass; Feed intake; Stool consistency
• Área do conhecimento CNPq: CNPQ::CIENCIAS BIOLOGICAS::BIOFISICA
• Link de acesso: http://www.bdtd.uerj.br/handle/1/16213

Whole body vibration (WBV) exercise is generated when a body is exposed to mechanical vibration produced in oscillating/vibratory platform. The clinical use of WBV exercise has revealed important findings, as the increase of muscle power and strength, improvement of balance, increase bone mineral density and aspects related to quality of life, and can be used in the prevention/treatment of diseases. As the use of WBV exercise has increased, the development of experimental models to evaluate, in controlled ways, the effect of this exercise is desirable. The association between WBV exercise and natural products would be an important tool in the management of diseases. Natural products have been used by human beings as food and medicine. However, the mechanism of action and the efficacy of these products in most cases lack scientific validation. Coriandrum sativum (coriander) is an herbaceous plant that been used in traditional medicine on the treatment of diabetes and gastrointestinal diseases. Following this idea, the aim of this study was to evaluate in Wistar rats with and without type 1 diabetes mellitus (T1DM), the biological effect of association between WBV exercise and an aqueous extract of coriander. The animals were separated equally in four groups. The control group received deionized water. The group treated with coriander received the extract of coriander. The rats that were exposed to WBV exercises also received deionized water. A group of animals received coriander and was exposed to WBV. All steps described above were also performed with animals with T1DM. The Diabetes was induced by intraperitoneal injection of 150 mg/kg alloxan. Were evaluated the biodistribution of sodium pertechnatate (Na99mTcO4), concentration of some plasma biomarkers, body mass, feed intake and stool consistency. The results in healthy rats showed a decrease in the percentage of radioactivity per gram (% ATI / g) in the testis in rats submitted to WBV exercise compared to that treated with coriander extract. There is no significant alteration on the concentrations of the plasma biomarkers. The feed intake showed a statistically significant increase in rats submitted to WBV exercise. No significant difference on the body mass was found. The stool analysis showed a statistical difference on the consistency between coriander group and all the other groups. In conclusion, it was verified modifications in some biochemical/physiological parameters of the rats submitted to WBV exercise which would be capable to increase the feed intake without changing the body mass, and normalizing the stool consistency altered by the coriander supplementation; and in animals with T1DM no difference was found in the studied parameters with these interventions.