Síntese de compostos de coordenação de rutênio com ligantes bioativos: Busca por novos agentes antitumorais

• Ano de defesa: 2022
• Autor(a) principal: Almeida, Jessica Cruz de Luca de
• Outros Autores: [e-mail]
• Orientador(a): Lessa, Josane Alves
• Banca de defesa: Carvalho, Nakédia Maysa Freitas , Lima, Juliana Fonseca de , Barros Neto, José Celestino de , Lachter, Elizabeth Roditi
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Estado do Rio de Janeiro
• Programa de Pós-Graduação: Programa de Pós-Graduação em Química
• Departamento: Centro de Tecnologia e Ciências::Instituto de Química
• País: Brasil
• Palavras-chave em Português: Complexo de rutênio; Tiossemicarbazonas; Câncer; Antitumor
• Palavras-chave em Inglês: Ruthenium complexes; Thiosemicarbazone
• Área do conhecimento CNPq: CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA
• Link de acesso: http://www.bdtd.uerj.br/handle/1/18949

Cancer is the second deadliest disease in the world. The predictions of the World Health Organization for an increase in the number of cases in the coming years are alarming. The countries with the highest mortality are those with low and middle income, then investments are needed for faster diagnoses and that enable early treatment, thus reducing the number of deaths. The complexes have been used as antitumor drugs since the accidental discovery of cisplatin. From this, many other platinum complexes were developed, although among their disadvantages is myelosuppression, acquired resistance and toxicity. Ruthenium complexes have received special attention due to their low toxicity. It can also be seen through the bibliography of the present work that many ruthenium complexes have a greater cytotoxic action than cisplatin, making them good candidates for their antiproliferative action. This study focused on the synthesis and characterization of four pyrazinamide-derived thiosemicarbazones produced and eight Ru(II) and Ru(III) complexes. The four Ru(II) complexes containing dimethylsulfoxide (DMSO) were produced from the precursor RuCl2(DMSO)4], in the molar ratio thiosemicarbazone/metal 1:1. While the Ru(III) complexes were obtained from the hydrated salt of ruthenium chloride III in the ligand/metal ratio 2:1, as suggested by the elemental analysis of the molecules that are in agreement with the proposed structures. The other characterizations point to obtaining and purity of the complexes. The analysis of the infrared spectra indicates that the coordination of ruthenium with the thiosemicarbazone ligands occurs through the sulfur atom and the azomethine nitrogen. For Ru(II) complexes, it is suggested that the precursor complex loses two DMSO ligands, being them O-DMSO, which is more labile and coordinates to ruthenium through the oxygen atom, and an S-DMSO, coordinated to from sulfur, remaining then two SDMSO in the proposed complexes. Ru(III) complexes have a chloride as counter ion, while Ru(II) complexes are neutral. From the mass spectrometry analyzes it is possible to suggest the masses of the ions of the complexes and the isotopic profile corresponding to the proposed structure. Further studies may be carried out to evaluate the antiproliferative properties of the developed complexes.