Síntese e caracterização de nanocápsulas de capsaicina em óleo de alecrim

• Ano de defesa: 2015
• Autor(a) principal: Carvalho, Leandro Barreiros de
• Orientador(a): Cesar, Deborah Vargas
• Banca de defesa: Costa, Valéria Gonçalves , Lago, Dalva Cristina Baptista do , Leite, Marcia Christina Amorim Moreira
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Estado do Rio de Janeiro
• Programa de Pós-Graduação: Programa de Pós-Graduação em Engenharia Química
• Departamento: Centro de Tecnologia e Ciências::Instituto de Química
• País: BR
• Palavras-chave em Português: Nanotecnologia; nanocápsulas; síntese; capsaicina; caracterização
• Palavras-chave em Inglês: Nanotechnology; nanocapsules; synthesis; capsaicin; characterization
• Área do conhecimento CNPq: CNPQ::ENGENHARIAS::ENGENHARIA QUIMICA
• Link de acesso: http://www.bdtd.uerj.br/handle/1/12037

Nanocapsules are carriers nanomaterials assets, formed by a polymer shell wrapped around a lipophilic core. In addition to the efficiency improvement, interest in the use of these compounds in the development of nanomaterials is the possibility of improvement in selectivity of action, an increase in surface area of active contact, active permeation modulation or the targeting to a specific site of action . This paper presents a study on the synthesis and characterization of materials nanocoated using capsaicin as an active and essential oil of rosemary as oil core. To this, they were evaluated nanocapsules preparation methodology capsaicin rosemary essential oil, and the effects of synthesis parameters in the encapsulation process. Prepared nanocapsules were characterized by scanning electron microscopy (SEM), electrophoretic mobility (Zeta Potential), dynamic light scattering (DLS) and absorption spectroscopy Infrared Fourier transform with accessory attenuated total reflectance (FTIR / ATR). The Eudragit S100® polymer proved to be the most suitable for the formation of nanocapsule, for introducing more homogeneous morphology and lower porosity. The infrared analysis and scanning electron microscopy showed that capsaicin was solubilized in rosemary essential oil in the amount used in this work. The nanocapsules were prepared at a concentration of 0.3 mg / mL capsaicin, which were varied concentrations of the polymer and the aqueous surfactant phase. The t-test was used for statistical analysis of results of the datasets, considering the significance level of p <0.05. The nanocapsules obtained showed pH below 7.00, spherical morphology and the suspensions with 10% more polysorbate 80 showed the best result sets for size (99.2 ± 0.9 nm), IPD (0.198 ± 0.057) and Zeta potential (-19.00 ± 2.51 mV). The results demonstrate that the nanocapsules containing capsaicin rosemary essential oil is stable and promising systems for topical application