Development of single particle ICP-MS method for silver nanoparticles sizing on biological matrices

Detalhes bibliográficos
Ano de defesa: 2019
Autor(a) principal: Souza, André Luiz Marques de
Orientador(a): Batista, Bruno Lemos
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: eng
Instituição de defesa: Universidade Federal do ABC
Programa de Pós-Graduação: Programa de Pós-Graduação em Ciência e Tecnologia/Química
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Link de acesso: http://biblioteca.ufabc.edu.br/index.php?codigo_sophia=120783&midiaext=78021
http://biblioteca.ufabc.edu.br/index.php?codigo_sophia=120783&midiaext=78021/index.php?codigo_sophia=120783&midiaext=78022
Resumo: Universidade Federal do ABC
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisDevelopment of single particle ICP-MS method for silver nanoparticles sizing on biological matrices2019-09-17Batista, Bruno LemosSouza, André Luiz Marques deUniversidade Federal do ABCPrograma de Pós-Graduação em Ciência e Tecnologia/QuímicaUniversidade Federal do ABCengSILVER NANOPARTICLESSPICP-MSNANOTECHNOLOGYBIOLOGICAL SAMPLESMONITORINGNANOPARTNANOTECNOLOGIAAMOSTRAS BIOLÓGICASMONITORAMENTOPROGRAMA DE PUniversidade Federal do ABCCoordenação de Aperfeiçoamento de Pessoal de Nivel SuperiorFundação de Amparo a Pesquisa do Estado de São PauloNanomaterials can be defined as a suspension in which at least 50% of components are found between 10-100 nm in one-dimension, at least. These materials are present in several products used by society. Silver nanoparticles (AgNPs) are used as pesticides, food additives, makeup and skincare products, and electronic compounds. Although their presence in the market is consolidated, toxicological and environmental effects are unknown. For this reason, new studies and methods for control and monitoring are necessary. There is a lack of methods for the determination and sizing of NPs in biological samples. Traditional analytical techniques for sizing (such as Dynamic Light Scattering and Atomic Force Microscopy) present some disadvantages as the interferences of the matrix where the NPs are present and low analytical frequency. The single particle inductively coupled mass spectrometry (spICP-MS) method presents as a new tool to overcome the detection, sizing and quantification of metallic NPs in complex matrices. Therefore, the current work aimed the study AgNPs detection in human matrices: blood-plasma, sweat, urine and saliva. It was studied the influence of sample dilution, concentration of NPs in the samples and the storage time in AgNPs detection, sizing and quantification. Firstly, it was observed a 1:20 matrix dilution was able to allow AgNPs 2 ìg L -1 detection in urine, saliva and plasma; a 1:10 matrix dilution was able to allow AgNPs 2 ìg L -1 detection in sweat. Regarding the levels of AgNPs, concentrations ³ 5 ìg L-1 presented an adverse signal-background differentiation profile for detection of AgNPs. Higher concentrations of AgNPs in solution caused interference of matrix compatibility due to Ag+ detection by spICP-MS, generating false-positive results. Finally, it was observed that a 144h storage for AgNPs 2 ìg L -1 solutions in 1:20 diluted urine and water allowed the AgNPs detection. AgNPs 2 ìg L -1 did not present a good signal-background differentiation in a 1:20 diluted plasma solution after a 144h storage. This study provided new knowledge for AgNPs monitoring in biological samples, helping on the new regulations proposed by Environmental and Health Agencies.http://biblioteca.ufabc.edu.br/index.php?codigo_sophia=120783&midiaext=78021http://biblioteca.ufabc.edu.br/index.php?codigo_sophia=120783&midiaext=78021/index.php?codigo_sophia=120783&midiaext=78022application/pdfapplication/pdfreponame:Repositório Institucional da UFABCinstname:Universidade Federal do ABC (UFABC)instacron:UFABCinfo:eu-repo/semantics/openAccess2026-01-15T21:48:10Zoai:BDTD:120783Repositório InstitucionalPUBhttp://www.biblioteca.ufabc.edu.br/oai/oai.phpopendoar:2020-02-12T19:34:27Repositório Institucional da UFABC - Universidade Federal do ABC (UFABC)false
dc.title.pt.fl_str_mv Development of single particle ICP-MS method for silver nanoparticles sizing on biological matrices
title Development of single particle ICP-MS method for silver nanoparticles sizing on biological matrices
spellingShingle Development of single particle ICP-MS method for silver nanoparticles sizing on biological matrices
Souza, André Luiz Marques de
title_short Development of single particle ICP-MS method for silver nanoparticles sizing on biological matrices
title_full Development of single particle ICP-MS method for silver nanoparticles sizing on biological matrices
title_fullStr Development of single particle ICP-MS method for silver nanoparticles sizing on biological matrices
title_full_unstemmed Development of single particle ICP-MS method for silver nanoparticles sizing on biological matrices
title_sort Development of single particle ICP-MS method for silver nanoparticles sizing on biological matrices
author Souza, André Luiz Marques de
author_facet Souza, André Luiz Marques de
author_role author
dc.contributor.advisor1.fl_str_mv Batista, Bruno Lemos
dc.contributor.author.fl_str_mv Souza, André Luiz Marques de
contributor_str_mv Batista, Bruno Lemos
description Universidade Federal do ABC
publishDate 2019
dc.date.issued.fl_str_mv 2019-09-17
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://biblioteca.ufabc.edu.br/index.php?codigo_sophia=120783&midiaext=78021
http://biblioteca.ufabc.edu.br/index.php?codigo_sophia=120783&midiaext=78021/index.php?codigo_sophia=120783&midiaext=78022
url http://biblioteca.ufabc.edu.br/index.php?codigo_sophia=120783&midiaext=78021
http://biblioteca.ufabc.edu.br/index.php?codigo_sophia=120783&midiaext=78021/index.php?codigo_sophia=120783&midiaext=78022
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do ABC
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Ciência e Tecnologia/Química
dc.publisher.initials.fl_str_mv Universidade Federal do ABC
publisher.none.fl_str_mv Universidade Federal do ABC
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFABC
instname:Universidade Federal do ABC (UFABC)
instacron:UFABC
instname_str Universidade Federal do ABC (UFABC)
instacron_str UFABC
institution UFABC
reponame_str Repositório Institucional da UFABC
collection Repositório Institucional da UFABC
repository.name.fl_str_mv Repositório Institucional da UFABC - Universidade Federal do ABC (UFABC)
repository.mail.fl_str_mv
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