Estudo farmacológico do Cymbogon citratus (D.C.) STAPF

Detalhes bibliográficos
Ano de defesa: 1984
Autor(a) principal: Ferreira, Maria do Socorro Cordeiro
Orientador(a): Fonteles, Manassés Claudino
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Não Informado pela instituição
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Cymbopogon
Farmacologia
Estrogênios
Histamina
Link de acesso: http://www.repositorio.ufc.br/handle/riufc/65896
Resumo: A pharmacological study of. Cymbopogon citratus has been made studying its essencial oil, hydrolate and citral, the last compound beeing a pure component of the oil. These drugs promoted a spasmolitic effect on gut smooth muscle, proprably inespecific in nature. A previous pharmacological screening demonstrated that the tree substances are devoided of effects on cardiac and striated muscle, as well as on arterial blood pressure and on dog diuresis. The LD5O of the essencial oil in mice was 0,7ml, as determined by the method of Tainter and Miller. The studies were conducted mainly on duodenum of the rabbit, uterine preparation of the rat pretreated by estrogens and guinea pig ileum. In all the preparations , hydrolate or pseudohydrolate and citral blocked the spasms produced by Ace- tilcholine or barium chloride and inhibited the pepdular move- ment spontaneously observed in rabbit duodenum. A more detailed study was conducted in isolated guinea pig ileum, to study the blockade of citral towards other mediai tors such as histamine, serotonin, bradikynin and Acetilcholi-ne; under this treatment citral promoted a blocked of the ago- nist effects produced by these drugs.
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spelling Ferreira, Maria do Socorro CordeiroFonteles, Manassés Claudino2022-05-17T16:11:59Z2022-05-17T16:11:59Z1984FERREIRA, Maria do Socorro Cordeiro. Estudo farmacológico do Cymbogon citratus (D.C.) STAPF. 1984. 124 f. Dissertação (Mestrado em Farmacologia)- Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 1984. Disponível em: http://www.repositorio.ufc.br/handle/riufc/65896. Acesso em: 17/05/2022.http://www.repositorio.ufc.br/handle/riufc/65896A pharmacological study of. Cymbopogon citratus has been made studying its essencial oil, hydrolate and citral, the last compound beeing a pure component of the oil. These drugs promoted a spasmolitic effect on gut smooth muscle, proprably inespecific in nature. A previous pharmacological screening demonstrated that the tree substances are devoided of effects on cardiac and striated muscle, as well as on arterial blood pressure and on dog diuresis. The LD5O of the essencial oil in mice was 0,7ml, as determined by the method of Tainter and Miller. The studies were conducted mainly on duodenum of the rabbit, uterine preparation of the rat pretreated by estrogens and guinea pig ileum. In all the preparations , hydrolate or pseudohydrolate and citral blocked the spasms produced by Ace- tilcholine or barium chloride and inhibited the pepdular move- ment spontaneously observed in rabbit duodenum. A more detailed study was conducted in isolated guinea pig ileum, to study the blockade of citral towards other mediai tors such as histamine, serotonin, bradikynin and Acetilcholi-ne; under this treatment citral promoted a blocked of the ago- nist effects produced by these drugs.CymbopogonFarmacologiaEstrogêniosHistaminaEstudo farmacológico do Cymbogon citratus (D.C.) STAPFinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisporreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-82152http://repositorio.ufc.br/bitstream/riufc/65896/2/license.txtfb3ad2d23d9790966439580114baefafMD52ORIGINAL1984_dis_mscferreira.pdf1984_dis_mscferreira.pdfapplication/pdf4645656http://repositorio.ufc.br/bitstream/riufc/65896/1/1984_dis_mscferreira.pdf09ffe8d0411db50bda4664009ecc5f13MD51riufc/658962022-05-17 13:15:43.998oai:repositorio.ufc.br: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Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2022-05-17T16:15:43Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.pt_BR.fl_str_mv Estudo farmacológico do Cymbogon citratus (D.C.) STAPF
title Estudo farmacológico do Cymbogon citratus (D.C.) STAPF
spellingShingle Estudo farmacológico do Cymbogon citratus (D.C.) STAPF
Ferreira, Maria do Socorro Cordeiro
Cymbopogon
Farmacologia
Estrogênios
Histamina
title_short Estudo farmacológico do Cymbogon citratus (D.C.) STAPF
title_full Estudo farmacológico do Cymbogon citratus (D.C.) STAPF
title_fullStr Estudo farmacológico do Cymbogon citratus (D.C.) STAPF
title_full_unstemmed Estudo farmacológico do Cymbogon citratus (D.C.) STAPF
title_sort Estudo farmacológico do Cymbogon citratus (D.C.) STAPF
author Ferreira, Maria do Socorro Cordeiro
author_facet Ferreira, Maria do Socorro Cordeiro
author_role author
dc.contributor.author.fl_str_mv Ferreira, Maria do Socorro Cordeiro
dc.contributor.advisor1.fl_str_mv Fonteles, Manassés Claudino
contributor_str_mv Fonteles, Manassés Claudino
dc.subject.por.fl_str_mv Cymbopogon
Farmacologia
Estrogênios
Histamina
topic Cymbopogon
Farmacologia
Estrogênios
Histamina
description A pharmacological study of. Cymbopogon citratus has been made studying its essencial oil, hydrolate and citral, the last compound beeing a pure component of the oil. These drugs promoted a spasmolitic effect on gut smooth muscle, proprably inespecific in nature. A previous pharmacological screening demonstrated that the tree substances are devoided of effects on cardiac and striated muscle, as well as on arterial blood pressure and on dog diuresis. The LD5O of the essencial oil in mice was 0,7ml, as determined by the method of Tainter and Miller. The studies were conducted mainly on duodenum of the rabbit, uterine preparation of the rat pretreated by estrogens and guinea pig ileum. In all the preparations , hydrolate or pseudohydrolate and citral blocked the spasms produced by Ace- tilcholine or barium chloride and inhibited the pepdular move- ment spontaneously observed in rabbit duodenum. A more detailed study was conducted in isolated guinea pig ileum, to study the blockade of citral towards other mediai tors such as histamine, serotonin, bradikynin and Acetilcholi-ne; under this treatment citral promoted a blocked of the ago- nist effects produced by these drugs.
publishDate 1984
dc.date.issued.fl_str_mv 1984
dc.date.accessioned.fl_str_mv 2022-05-17T16:11:59Z
dc.date.available.fl_str_mv 2022-05-17T16:11:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, Maria do Socorro Cordeiro. Estudo farmacológico do Cymbogon citratus (D.C.) STAPF. 1984. 124 f. Dissertação (Mestrado em Farmacologia)- Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 1984. Disponível em: http://www.repositorio.ufc.br/handle/riufc/65896. Acesso em: 17/05/2022.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufc.br/handle/riufc/65896
identifier_str_mv FERREIRA, Maria do Socorro Cordeiro. Estudo farmacológico do Cymbogon citratus (D.C.) STAPF. 1984. 124 f. Dissertação (Mestrado em Farmacologia)- Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 1984. Disponível em: http://www.repositorio.ufc.br/handle/riufc/65896. Acesso em: 17/05/2022.
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