Motilidade esofágica e influência de manobras inspiratórias padronizadas na pressão do esfíncter esofágico inferior de pacientes com esofagite erosiva leve

• Ano de defesa: 2010
• Autor(a) principal: Martins, Giovanni Bezerra
• Orientador(a): Souza, Miguel Ângelo Nobre e
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Diafragma; Esofagite; Refluxo Gastroesofágico; Esfíncter Esofágico Inferior
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/7326

The behavior of the lower esophageal sphincter (LES) was studied by manometry in 21 healthy volunteers of both gender, aged 20-47 years who were divided into two groups: one group called the ESOPHAGITIS (GE) and a second group , the CONTROL group (GC). The GE was composed of 13 patients diagnosed with mild reflux esophagitis without hiatal hernia or hernias up to 2 cm. The GC was of healthy volunteers. A previous interview was conducted where the symptoms of patients was recorded by scores. The examination was performed with a probe Dentsleeve. The survey consisted of two phases. Initially standardized ventilatory maneuvers were performed: respiratory sinus arrhythmia (ASR), forced inspiration in the strength of a linear inspiratory resistance valve (Threshold ® IMT) with loads of 17, 35 and 70 cmH2O. Finally, after a standardized caloric meal, we proceeded to the observation of spontaneous transient relaxation of the LES (RTEEEIs) for one hour. All patients with esophagitis had heartburn. Regurgitation occurred in 84.6% and dysphagia in 69.2%. The basal LES pressure in subjects with reflux esophagitis was similar to the group of healthy volunteers (GC = 25.1 ± 4.1 versus 20.1 ± GE = 2.1, p = 0251). The maximum pressure during the maneuver of the EEI during the ASR was lower in GE (94.3 ± 9.4 mmHg versus 28.8 ± 13.85 mmHg, p = 0.046). The contraction of the LES pressure during inspiration with a load of 70 cmH2O was lower in the GC (166.6 ± 18 mmHg versus 121.2 ± 11.9 mmHg, p = 0.041). This pressure was positively correlated with basal LES pressure (r2 = 0.224; p = 0.023). The number of spontaneous relaxations of the LES per hour was higher in GE {[15 (6-20)] versus [22 (9-38)], p = 0.025}. The total duration of all RTEEEI was also higher in the GC (332.0 ± 72.1 versus 711.2 ± 131.3, p = 0.078), but did not reach statistical significance. The average duration of relaxation was not different between the two groups grupos (GC = 23.3 ± 2.2 versus GE = 28.2 ± 3.1; p= 0.337). We conclude that the contraction pressure of antireflux barrier in patients with erosive esophagitis is lower than in healthy volunteers, even when they have normal basal pressure of the LES.