Espalhamento Raman na risperidona em condições extremas de temperatura

Detalhes bibliográficos
Ano de defesa: 2022
Autor(a) principal: Gomes, Wagner Pereira
Orientador(a): Freire, Paulo de Tarso Cavalcante
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Não Informado pela instituição
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Risperidona
Espectroscopia Raman
DSC
Baixas temperaturas
Altas temperaturas
Link de acesso: http://www.repositorio.ufc.br/handle/riufc/67685
Resumo: In this work, the medicine risperidone (C23H27FN4O2) was analyzed using Raman spectroscopy techniques under extreme temperature conditions, in order to investigate its vibrational properties. Risperidone is a medicine classified as an atypical antipsychotic, used in the treatment of schizophrenia, autism in children and adolescents and bipolar disorder. The study of medicine properties and their changes caused by thermodynamic variations has been gaining great importance in the pharmaceutical industry, since the changes affect the quality and functioning of these medicines. Therefore, this analysis was carried out in order to understand the behavior of crystal structure of risperidone under a wide temperature variation. DSC (Differential Scanning Calorimetry) thermal analysis experiments were performed in the range between 133 K and 653 K (-140 °C and 380 °C) and Raman spectroscopy at low temperatures, up to 12 K (-261 °C) and at high temperatures, up to 393 K (120 C). The DSC experiment showed that risperidone does not show any phase transition at low temperatures while at high temperatures the DSC experiment shows an endothermic peak at 173 °C, related to melting point and two exothermic peaks, at 210 °C and 250 °C, possibly associated with the decomposition of the sample. The results of the low temperature and high temperature Raman spectroscopy experiments of risperidone showed little change in the Raman spectra, with no indication that the material undergoes any phase transition. Therefore, the medicine risperidone with monoclinic structure remains stable over the entire temperature range between 12 K and 393 K.
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spelling Gomes, Wagner PereiraFreire, Paulo de Tarso Cavalcante2022-08-11T13:42:51Z2022-08-11T13:42:51Z2022GOMES, W. P. Espalhamento Raman na risperidona em condições extremas de temperatura. 2022. 92 f. Dissertação (Mestrado em Física) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2022.http://www.repositorio.ufc.br/handle/riufc/67685In this work, the medicine risperidone (C23H27FN4O2) was analyzed using Raman spectroscopy techniques under extreme temperature conditions, in order to investigate its vibrational properties. Risperidone is a medicine classified as an atypical antipsychotic, used in the treatment of schizophrenia, autism in children and adolescents and bipolar disorder. The study of medicine properties and their changes caused by thermodynamic variations has been gaining great importance in the pharmaceutical industry, since the changes affect the quality and functioning of these medicines. Therefore, this analysis was carried out in order to understand the behavior of crystal structure of risperidone under a wide temperature variation. DSC (Differential Scanning Calorimetry) thermal analysis experiments were performed in the range between 133 K and 653 K (-140 °C and 380 °C) and Raman spectroscopy at low temperatures, up to 12 K (-261 °C) and at high temperatures, up to 393 K (120 C). The DSC experiment showed that risperidone does not show any phase transition at low temperatures while at high temperatures the DSC experiment shows an endothermic peak at 173 °C, related to melting point and two exothermic peaks, at 210 °C and 250 °C, possibly associated with the decomposition of the sample. The results of the low temperature and high temperature Raman spectroscopy experiments of risperidone showed little change in the Raman spectra, with no indication that the material undergoes any phase transition. Therefore, the medicine risperidone with monoclinic structure remains stable over the entire temperature range between 12 K and 393 K.Neste trabalho o fármaco risperidona (C23H27FN4O2) foi analisado utilizando técnicas de espectroscopia Raman em condições extremas de temperatura, com o objetivo de investigar as suas propriedades vibracionais. A risperidona é um fármaco classificado como antipsicótico atípico, usado no tratamento de esquizofrenia, autismo em crianças e adolescentes e transtorno bipolar. O estudo das propriedades dos fármacos e suas mudanças causadas por variações termodinâmicas vem ganhando grande importância na indústria farmacêutica, em razão das mudanças afetarem a qualidade e o funcionamento desses medicamentos. Por isso, foi realizada essa análise na perspectiva de entender o comportamento da risperidona sob uma larga variação de temperatura. Foram realizados experimentos de análise térmica DSC (Calorimetria exploratória diferencial) no intervalo entre 133 K e 653 K (-140 °C e 380 °C) e experimentos de espectroscopia Raman em baixas temperaturas, até 12 K (-261 °C) e em altas temperaturas, até 393 K (120 °C). O experimento de DSC mostrou que a risperidona não apresenta nenhuma transição de fase em baixas temperaturas enquanto em altas temperaturas o experimento de DSC apresenta um pico endotérmico em 173 °C, relacionado ao ponto de fusão e dois picos exotérmicos, em 210 °C e 250 °C, possivelmente associados à decomposição da amostra. Os resultados dos experimentos de espectroscopia Raman em baixas temperaturas e em altas temperaturas da risperidona apresentaram poucas alterações nos espectros Raman, sem nenhum indicativo de que o material sofra alguma transição de fase. Portanto, o fármaco risperidona com estrutura monoclínica permanece estável em todo o intervalo de temperatura entre 12 K e 393 K.RisperidonaEspectroscopia RamanDSCBaixas temperaturasAltas temperaturasEspalhamento Raman na risperidona em condições extremas de temperaturainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisporreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccessORIGINAL2022_dis_wpgomes.pdf2022_dis_wpgomes.pdfapplication/pdf5517772http://repositorio.ufc.br/bitstream/riufc/67685/5/2022_dis_wpgomes.pdfd1ff1ec64074082243d6005b9701d78eMD55LICENSElicense.txtlicense.txttext/plain; charset=utf-82152http://repositorio.ufc.br/bitstream/riufc/67685/4/license.txtfb3ad2d23d9790966439580114baefafMD54riufc/676852022-08-11 10:43:48.549oai:repositorio.ufc.br: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Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2022-08-11T13:43:48Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.pt_BR.fl_str_mv Espalhamento Raman na risperidona em condições extremas de temperatura
title Espalhamento Raman na risperidona em condições extremas de temperatura
spellingShingle Espalhamento Raman na risperidona em condições extremas de temperatura
Gomes, Wagner Pereira
Risperidona
Espectroscopia Raman
DSC
Baixas temperaturas
Altas temperaturas
title_short Espalhamento Raman na risperidona em condições extremas de temperatura
title_full Espalhamento Raman na risperidona em condições extremas de temperatura
title_fullStr Espalhamento Raman na risperidona em condições extremas de temperatura
title_full_unstemmed Espalhamento Raman na risperidona em condições extremas de temperatura
title_sort Espalhamento Raman na risperidona em condições extremas de temperatura
author Gomes, Wagner Pereira
author_facet Gomes, Wagner Pereira
author_role author
dc.contributor.author.fl_str_mv Gomes, Wagner Pereira
dc.contributor.advisor1.fl_str_mv Freire, Paulo de Tarso Cavalcante
contributor_str_mv Freire, Paulo de Tarso Cavalcante
dc.subject.por.fl_str_mv Risperidona
Espectroscopia Raman
DSC
Baixas temperaturas
Altas temperaturas
topic Risperidona
Espectroscopia Raman
DSC
Baixas temperaturas
Altas temperaturas
description In this work, the medicine risperidone (C23H27FN4O2) was analyzed using Raman spectroscopy techniques under extreme temperature conditions, in order to investigate its vibrational properties. Risperidone is a medicine classified as an atypical antipsychotic, used in the treatment of schizophrenia, autism in children and adolescents and bipolar disorder. The study of medicine properties and their changes caused by thermodynamic variations has been gaining great importance in the pharmaceutical industry, since the changes affect the quality and functioning of these medicines. Therefore, this analysis was carried out in order to understand the behavior of crystal structure of risperidone under a wide temperature variation. DSC (Differential Scanning Calorimetry) thermal analysis experiments were performed in the range between 133 K and 653 K (-140 °C and 380 °C) and Raman spectroscopy at low temperatures, up to 12 K (-261 °C) and at high temperatures, up to 393 K (120 C). The DSC experiment showed that risperidone does not show any phase transition at low temperatures while at high temperatures the DSC experiment shows an endothermic peak at 173 °C, related to melting point and two exothermic peaks, at 210 °C and 250 °C, possibly associated with the decomposition of the sample. The results of the low temperature and high temperature Raman spectroscopy experiments of risperidone showed little change in the Raman spectra, with no indication that the material undergoes any phase transition. Therefore, the medicine risperidone with monoclinic structure remains stable over the entire temperature range between 12 K and 393 K.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-08-11T13:42:51Z
dc.date.available.fl_str_mv 2022-08-11T13:42:51Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, W. P. Espalhamento Raman na risperidona em condições extremas de temperatura. 2022. 92 f. Dissertação (Mestrado em Física) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2022.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufc.br/handle/riufc/67685
identifier_str_mv GOMES, W. P. Espalhamento Raman na risperidona em condições extremas de temperatura. 2022. 92 f. Dissertação (Mestrado em Física) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2022.
url http://www.repositorio.ufc.br/handle/riufc/67685
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
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reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
bitstream.url.fl_str_mv http://repositorio.ufc.br/bitstream/riufc/67685/5/2022_dis_wpgomes.pdf
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