Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico

Detalhes bibliográficos
Ano de defesa: 2004
Autor(a) principal: Lima, Antonio Carlos Nogueira de
Orientador(a): Nunes, Alberto Jorge Pinto
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: http://www.teses.ufc.br/
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://www.repositorio.ufc.br/handle/riufc/1230
Resumo: Shrimp culture is a very important economic activity in the world and the fastest growing industry in Northeast Brazil. Problem with diseases are common in aquaculture and at the least seven species of Vibrio bacteria have been registered infecting shrimps during different culture stages. Oxytetracycline (OTC) has been widely used against these pathogens. In this research the distribution and residue depletion of OTC in Litopenaeus vannamei tissue were evaluated after 14 days of exposure to medicated feed containing 4g.kg-1. Two trials were conducted: in indoor tanks under laboratory controlled conditions and in outdoor encrosures installed in a commercial shrimp grow-out pond. Medicated animals were sampled periodically, during treatment period and thereafter. The tissue levels of OTC were measured by hight performance liquid cromatograph-HPLC. Although in both treatments shrimp were similar conditions, OTC peak concentrations were different. After 7 and 12 days off exposure to OTC, residual values in shrimp tissues were 17,21 μg.g-1 and 3,78 μg.g-1 for the laboratory and field studies, respectivally. Mean OTC residual tissue concentration observed both in the laboratory and field trial are within the limits of minimum inibitory concentration (MIC) refered to vibriosis treatment. During the first 72 hours after the treatment ceased drug residues dropped fast, slowing down afterwords. A save residue level of 0,1μg.g-1 following the European Community requirements, were attained at day sixteen of OTC withdrawl. After 25 days of OTC withdraw no drug residues could be detected. However, it is reccommended a longer withdrawl period as a safeward to obtain complet drug depletion.
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spelling Lima, Antonio Carlos Nogueira deGesteira, Tereza Cristina VasconcelosNunes, Alberto Jorge Pinto2011-11-23T18:58:44Z2011-11-23T18:58:44Z2004LIMA, Antonio Carlos Nogueira de. Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico. 2004, 63f. Dissertação (Mestrado em Ciências Marinhas Tropicais) – Instituto de Ciências do Mar, Universidade Federal do Ceará, Fortaleza, 2004.http://www.repositorio.ufc.br/handle/riufc/1230Shrimp culture is a very important economic activity in the world and the fastest growing industry in Northeast Brazil. Problem with diseases are common in aquaculture and at the least seven species of Vibrio bacteria have been registered infecting shrimps during different culture stages. Oxytetracycline (OTC) has been widely used against these pathogens. In this research the distribution and residue depletion of OTC in Litopenaeus vannamei tissue were evaluated after 14 days of exposure to medicated feed containing 4g.kg-1. Two trials were conducted: in indoor tanks under laboratory controlled conditions and in outdoor encrosures installed in a commercial shrimp grow-out pond. Medicated animals were sampled periodically, during treatment period and thereafter. The tissue levels of OTC were measured by hight performance liquid cromatograph-HPLC. Although in both treatments shrimp were similar conditions, OTC peak concentrations were different. After 7 and 12 days off exposure to OTC, residual values in shrimp tissues were 17,21 μg.g-1 and 3,78 μg.g-1 for the laboratory and field studies, respectivally. Mean OTC residual tissue concentration observed both in the laboratory and field trial are within the limits of minimum inibitory concentration (MIC) refered to vibriosis treatment. During the first 72 hours after the treatment ceased drug residues dropped fast, slowing down afterwords. A save residue level of 0,1μg.g-1 following the European Community requirements, were attained at day sixteen of OTC withdrawl. After 25 days of OTC withdraw no drug residues could be detected. However, it is reccommended a longer withdrawl period as a safeward to obtain complet drug depletion.O cultivo de camarões é uma importante atividade econômica e tornou-se a indústria que mais cresce no Nordeste brasileiro atualmente. Problemas com enfermidades são comuns na aqüicultura e pelo menos sete espécies de bactérias do gênero Vibrio têm sido registradas infectando camarões durante diferentes estágios de cultivo. A oxitetraciclina (OTC) tem sido utilizada mundialmente contra esses patógenos. Na presente pesquisa, a distribuição e depleção de resíduos de OTC no tecido de Litopenaeus vannamei foram avaliadas depois de 7 dias de exposição à ração medicada contendo 4g.kg-1. Foram conduzidos dois experimentos: em tanques sob condições controladas em laboratório e em gaiolas instaladas em um viveiro de uma unidade de cultivo. Os animais medicados foram amostrados periodicamente, durante o tratamento e pós-tratamento. Os níveis de OTC foram analisados por cromatografia líquida de alta eficiência-CLAE. Embora em ambos os ambientes experimentais o tratamento tenha sido semelhante, os picos de OTC foram diferentes. Depois de 7 e 12 dias de exposição, as concentrações no tecido dos camarões foram 17,21 μg.g-1 e 3,78 μg.g-1 nos estudos realizados em laboratório e campo, respectivamente. A concentração média observada nos ambientes em estudo manteve-se dentro dos limites da concentração inibitória mínima-CIM, referida para o tratamento de vibrioses. Durante as primeiras 72 horas após cessado o tratamento, resíduos da droga reduziram muito rapidamente, sendo eliminados mais lentamente depois deste período. O nível residual de segurança de 0,10 μg.g–1, imposta pela Comunidade Européia, foi alcançado no 16o. dia de pós-tratamento. Depois do 25o. dia nenhum resíduo da droga pôde ser detectado. Entretanto, devido à influência de fatores ambientes neste processo, recomenda-se um período de eliminação mais longo como medida de segurança para obtenção da eliminação completa da droga.http://www.teses.ufc.br/Litopenaeus vannameiOxitetraciclinaRecursos pesqueirosCarciniculturaResidualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibióticoResidual oxytetracycline in tissues of marine shrimp Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submitted to antibiotic treatmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisporreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccessORIGINAL2004_dis_acndlima.pdf2004_dis_acndlima.pdfapplication/pdf458671http://repositorio.ufc.br/bitstream/riufc/1230/1/2004_dis_acndlima.pdf442211ae93ecb93782b6e4c5883992e3MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ufc.br/bitstream/riufc/1230/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52riufc/12302022-09-21 15:12:10.565oai:repositorio.ufc.br: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Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2022-09-21T18:12:10Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.pt_BR.fl_str_mv Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico
dc.title.en.pt_BR.fl_str_mv Residual oxytetracycline in tissues of marine shrimp Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submitted to antibiotic treatment
title Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico
spellingShingle Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico
Lima, Antonio Carlos Nogueira de
Litopenaeus vannamei
Oxitetraciclina
Recursos pesqueiros
Carcinicultura
title_short Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico
title_full Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico
title_fullStr Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico
title_full_unstemmed Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico
title_sort Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico
author Lima, Antonio Carlos Nogueira de
author_facet Lima, Antonio Carlos Nogueira de
author_role author
dc.contributor.co-advisor.none.fl_str_mv Gesteira, Tereza Cristina Vasconcelos
dc.contributor.author.fl_str_mv Lima, Antonio Carlos Nogueira de
dc.contributor.advisor1.fl_str_mv Nunes, Alberto Jorge Pinto
contributor_str_mv Nunes, Alberto Jorge Pinto
dc.subject.por.fl_str_mv Litopenaeus vannamei
Oxitetraciclina
Recursos pesqueiros
Carcinicultura
topic Litopenaeus vannamei
Oxitetraciclina
Recursos pesqueiros
Carcinicultura
description Shrimp culture is a very important economic activity in the world and the fastest growing industry in Northeast Brazil. Problem with diseases are common in aquaculture and at the least seven species of Vibrio bacteria have been registered infecting shrimps during different culture stages. Oxytetracycline (OTC) has been widely used against these pathogens. In this research the distribution and residue depletion of OTC in Litopenaeus vannamei tissue were evaluated after 14 days of exposure to medicated feed containing 4g.kg-1. Two trials were conducted: in indoor tanks under laboratory controlled conditions and in outdoor encrosures installed in a commercial shrimp grow-out pond. Medicated animals were sampled periodically, during treatment period and thereafter. The tissue levels of OTC were measured by hight performance liquid cromatograph-HPLC. Although in both treatments shrimp were similar conditions, OTC peak concentrations were different. After 7 and 12 days off exposure to OTC, residual values in shrimp tissues were 17,21 μg.g-1 and 3,78 μg.g-1 for the laboratory and field studies, respectivally. Mean OTC residual tissue concentration observed both in the laboratory and field trial are within the limits of minimum inibitory concentration (MIC) refered to vibriosis treatment. During the first 72 hours after the treatment ceased drug residues dropped fast, slowing down afterwords. A save residue level of 0,1μg.g-1 following the European Community requirements, were attained at day sixteen of OTC withdrawl. After 25 days of OTC withdraw no drug residues could be detected. However, it is reccommended a longer withdrawl period as a safeward to obtain complet drug depletion.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2011-11-23T18:58:44Z
dc.date.available.fl_str_mv 2011-11-23T18:58:44Z
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dc.identifier.citation.fl_str_mv LIMA, Antonio Carlos Nogueira de. Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico. 2004, 63f. Dissertação (Mestrado em Ciências Marinhas Tropicais) – Instituto de Ciências do Mar, Universidade Federal do Ceará, Fortaleza, 2004.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufc.br/handle/riufc/1230
identifier_str_mv LIMA, Antonio Carlos Nogueira de. Residualidade da oxitetraciclina no tecido do camarão marinho Litopenaeus vannamei (Boone, 1931) (Crustacea, Decapoda) submetido a tratamento antibiótico. 2004, 63f. Dissertação (Mestrado em Ciências Marinhas Tropicais) – Instituto de Ciências do Mar, Universidade Federal do Ceará, Fortaleza, 2004.
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