Ensaio de métodos para a impregnacão do stent ureteral com carga farmacológica de tansulosina

• Ano de defesa: 2023
• Autor(a) principal: Silva, Guilherme Vitoriano
• Orientador(a): Oliveira, Ricardo Reges Maia de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA::CIRURGIA
• Link de acesso: http://repositorio.ufc.br/handle/riufc/75194

The prevalence of kidney stones can vary between 8-15% of a country's population. The most common age group is young adults aged 30 to 50, compromising the most productive time of their lives. In Brazil, it is estimated that the prevalence of people with kidney stones is 12%. Due to this prevalence, direct treatment costs have a high impact on the country. Furthermore, indirect costs due to the loss of working capacity of the young economically active population and social security costs due to absences must be taken into account. In patients with some urinary tract obstruction, it is common to use a ureteral catheter, also known as a ureteral stent, to restore adequate flow of urine from the kidney to the bladder. However, patients in whom the ureteral stent is implanted often complain of pain and lower urinary tract symptoms known as Ureteral Stent Syndrome (USS).Due to these effects, the ureteral stent has been associated with high consumption of analgesic medications, frequent returns to emergency rooms, preventing the patient from quickly returning to their daily activities. To reduce patient discomfort, tamsulosin has been used off-label. The present study talks about the development of an analytical procedure capable of measuring and defining the release profile of tamsulosin, in the compound mixed with organic matrices, for future impregnation of this drug in the ureteral stent. For drug quantification, mathematical models were proposed based on multivariate regression applied to a set of experiments carried out according to factorial planning and graphs generated by ultraviolet (UV) spectrophotometry that were treated by Savitzky-Golay filters, to reduce reading noise and interpretation of dosing results. For the formulated model, a value p≤0.05 was found, and it was verified that the calculated drug values match the values tabulated for testing. This work is pioneering, as there are no publications in the literature to date.